Search Results - "Arain, Hirra A."

APOE4 is associated with cognitive and pathological heterogeneity in patients with Alzheimer's disease: a systematic review by Emrani, Sheina, Arain, Hirra A, DeMarshall, Cassandra, Nuriel, Tal

“…Possession of the ε4 allele of apolipoprotein E (APOE) is the primary genetic risk factor for the sporadic form of Alzheimer's disease (AD). While researchers…”
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Human Lupus Plasma Pro-Atherogenic Effects on Cultured Macrophages Are Not Mitigated by Statin Therapy: A Mechanistic LAPS Substudy by Reiss, Allison B, Arain, Hirra A, Kasselman, Lora J, Renna, Heather A, Zhen, Juan, Voloshyna, Iryna, DeLeon, Joshua, Carsons, Steven E, Petri, Michelle

“…Atherosclerotic cardiovascular disease (CVD) remains a major cause of morbidity and mortality in persons with systemic lupus erythematosus (SLE, lupus)…”
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Alzheimer Disease Clinical Trials Targeting Amyloid: Lessons Learned From Success in Mice and Failure in Humans by Reiss, Allison B., Montufar, Natalie, DeLeon, Joshua, Pinkhasov, Aaron, Gomolin, Irving H., Glass, Amy D., Arain, Hirra A., Stecker, Mark M.

“…The goal of slowing or halting the development of Alzheimer disease (AD) has resulted in the huge allocation of resources by academic institutions and…”
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APOE4 is Associated with Differential Regional Vulnerability to Bioenergetic Deficits in Aged APOE Mice by Area-Gomez, Estela, Larrea, Delfina, Pera, Marta, Agrawal, Rishi R., Guilfoyle, David N., Pirhaji, Leila, Shannon, Kathleen, Arain, Hirra A., Ashok, Archana, Chen, Qiuying, Dillman, Allissa A., Figueroa, Helen Y., Cookson, Mark R., Gross, Steven S., Fraenkel, Ernest, Duff, Karen E., Nuriel, Tal

“…The ε4 allele of apolipoprotein E ( APOE ) is the dominant genetic risk factor for late-onset Alzheimer’s disease (AD). However, the reason for the association…”
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Signatures of disrupted synaptic maintenance in the entorhinal cortex of both pathology‐free APOE4 carriers and aged APOE4 mice: Molecular and cell biology/synaptic disruption by Arain, Hirra A., Kumar, Gautam, Figueroa, Helen Y., Cookson, Mark R., Mathews, Paul, Duff, Karen E., Nuriel, Tal

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Signatures of disrupted synaptic maintenance in the entorhinal cortex of both pathology‐free APOE4 carriers and aged APOE4 mice by Arain, Hirra A., Kumar, Gautam, Figueroa, Helen Y., Cookson, Mark R., Mathews, Paul, Duff, Karen E., Nuriel, Tal

“…Background The greatest genetic risk factor for late‐onset Alzheimer’s disease (AD) is the possession of the apolipoprotein E4 (APOE4) variant. Yet the…”
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APOE4 INDUCES REGION-SPECIFIC DYSFUNCTION IN THE ENTORHINAL CORTEX OF AGED APOE4 MICE by Arain, Hirra A., Figueroa, Helen Y., Area-Gomez, Estela, Duff, Karen E., Nuriel, Tal

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P3‐175: APOE4 INDUCES REGION‐SPECIFIC DYSFUNCTION IN THE ENTORHINAL CORTEX OF AGED APOE4 MICE by Arain, Hirra A., Figueroa, Helen Y., Area-Gomez, Estela, Duff, Karen E., Nuriel, Tal

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HMG‐CoA Reductase Inhibitors Do Not Ameliorate Progressive Atherogenic Changes In Human Macrophages Treated With Systemic Lupus Erythematosus Patient Plasma: Implications For Statin Use and Novel Insight Into Systemic Lupus Erythematosus by Arain, Hirra A., Petri, Michelle, Kasselman, Lora J., Renna, Heather A., Zhen, Juan, De Leon, Joshua, Carsons, Steven E., Reiss, Allison B., Dores, Michael R.

“…Systematic lupus erythematosus (SLE) is an inflammatory autoimmune disease that predisposes patients to develop atherosclerotic cardiovascular disease (CVD)…”
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