Search Results - "Arai, Kumiko"

Sodium 4-phenylbutyric acid prevents murine acetaminophen hepatotoxicity by minimizing endoplasmic reticulum stress by Kusama, Hiromi, Kon, Kazuyoshi, Ikejima, Kenichi, Arai, Kumiko, Aoyama, Tomonori, Uchiyama, Akira, Yamashina, Shunhei, Watanabe, Sumio

“…Background Acetaminophen (APAP) overdose induces severe oxidative stress followed by hepatocyte apoptosis/necrosis. Previous studies have indicated that…”
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Aging exacerbates high‐fat diet‐induced steatohepatitis through alteration in hepatic lipid metabolism in mice by Ishizuka, Kei, Kon, Kazuyoshi, Lee‐Okada, Hyeon‐Cheol, Arai, Kumiko, Uchiyama, Akira, Yamashina, Shunhei, Yokomizo, Takehiko, Ikejima, Kenichi

“…Background and Aim Aging is an independent risk factor for the progression of non‐alcoholic steatohepatitis. Here, we investigated the role of age‐related…”
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Sampler design for determining the personal exposure level of workers to vapor and mist of benzyl alcohol by Aono, Hiromi, Arai, Kumiko, Ono-Ogasawara, Mariko, Yamamuro, Kenji, Shimada, Masami, Okada, Takayuki, Kawamoto, Toshihiro

“…Objectives: This study aims to develop and validate a sampler to measure workers’ exposure to the vapor and mist of benzyl alcohol. Methods: Recovery rate,…”
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Ursolic acid ameliorates hepatic fibrosis in the rat by specific induction of apoptosis in hepatic stellate cells by Wang, Xu, Ikejima, Kenichi, Kon, Kazuyoshi, Arai, Kumiko, Aoyama, Tomonori, Okumura, Kyoko, Abe, Wataru, Sato, Nobuhiro, Watanabe, Sumio

“…Background & Aims Specific induction of cell death in activated hepatic stellate cells (HSCs) is a promising therapeutic strategy for hepatic fibrosis. In this…”
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The Chemical Chaperone 4‐Phenylbutyric Acid Prevents Alcohol‐Induced Liver Injury in Obese KK‐Ay Mice by Suzuki, Maiko, Kon, Kazuyoshi, Ikejima, Kenichi, Arai, Kumiko, Uchiyama, Akira, Aoyama, Tomonori, Yamashina, Shunhei, Ueno, Takashi, Watanabe, Sumio

“…Background Co‐occurrence of metabolic syndrome and chronic alcohol consumption is increasing worldwide. The present study investigated the effect of the…”
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Glycine prevents metabolic steatohepatitis in diabetic KK-Ay mice through modulation of hepatic innate immunity by Takashima, Shiori, Ikejima, Kenichi, Arai, Kumiko, Yokokawa, Junko, Kon, Kazuyoshi, Yamashina, Shunhei, Watanabe, Sumio

“…Strategies for prevention and treatment of nonalcoholic steatohepatitis remain to be established. We evaluated the effect of glycine on metabolic…”
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Abnormally Differentiated Subsets of Intestinal Macrophage Play a Key Role in Th1-Dominant Chronic Colitis through Excess Production of IL-12 and IL-23 in Response to Bacteria by Kamada, Nobuhiko, Hisamatsu, Tadakazu, Okamoto, Susumu, Sato, Toshiro, Matsuoka, Katsuyoshi, Arai, Kumiko, Nakai, Takaaki, Hasegawa, Akira, Inoue, Nagamu, Watanabe, Noriaki, Akagawa, Kiyoko S, Hibi, Toshifumi

“…Disorders in enteric bacteria recognition by intestinal macrophages (Mphi) are strongly correlated with the pathogenesis of chronic colitis; however the…”
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L‐carnitine prevents metabolic steatohepatitis in obese diabetic KK‐Ay mice by Kon, Kazuyoshi, Ikejima, Kenichi, Morinaga, Maki, Kusama, Hiromi, Arai, Kumiko, Aoyama, Tomonori, Uchiyama, Akira, Yamashina, Shunhei, Watanabe, Sumio

“…Aim Pharmacological treatment for metabolic syndrome‐related non‐alcoholic steatohepatitis has not been established. We investigated the effect of L‐carnitine,…”
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Evaluation and Comparison of the Antioxidative Potency of Various Carbohydrates Using Different Methods by Ajisaka, Katsumi, Agawa, Sayuri, Nagumo, Satomi, Kurato, Keisuke, Yokoyama, Tatsuya, Arai, Kumiko, Miyazaki, Tatsuo

“…A detailed analysis of the antioxidative activity of 12 carbohydrates including chondroitin sulfate, fucoidan, agaro-oligosaccharide, 2-deoxy-scyllo-inosose…”
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Role of apoptosis in acetaminophen hepatotoxicity by Kon, Kazuyoshi, Ikejima, Kenichi, Okumura, Kyoko, Aoyama, Tomonori, Arai, Kumiko, Takei, Yoshiyuki, Lemasters, John J, Sato, Nobuhiro

“…Acetaminophen overdose causes liver injury by mechanisms involving glutathione depletion, oxidative stress and mitochondrial dysfunction. The role of apoptosis…”
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Sodium 4-phenylbutyrate prevents murine dietary steatohepatitis caused by trans-fatty acid plus fructose by Morinaga, Maki, Kon, Kazuyoshi, Saito, Hiroaki, Arai, Kumiko, Kusama, Hiromi, Uchiyama, Akira, Yamashina, Shunhei, Ikejima, Kenichi, Watanabe, Sumio

“…Excess consumption of trans-fatty acid could increase the risk of non-alcoholic steatohepatitis (NASH); however, treatment targeting trans-fatty acid-induced…”
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Pioglitazone promotes survival and prevents hepatic regeneration failure after partial hepatectomy in obese and diabetic KK‐Ay mice by Aoyama, Tomonori, Ikejima, Kenichi, Kon, Kazuyoshi, Okumura, Kyoko, Arai, Kumiko, Watanabe, Sumio

“…Pathogenesis of metabolic syndrome–related nonalcoholic steatohepatitis (NASH) involves abnormal tissue‐repairing responses in the liver. We investigated the…”
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Su1552 GLYCINE PREVENTS STEATOHEPATITIS-ASSOCIATED HEPATOCARCINOGENESIS IN HEPATOCYTE-SPECIFIC PTEN KNOCKOUT MICE THROUGH OF LIPID PROFILES by Kon, Kazuyoshi, Arai, Kumiko, Uchiyama, Akira, Fukada, Hiroo, Yamashina, Shunhei, Ikejima, Kenichi

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Type I NKT cells are involved in exacerbation of steatohepatitis in aged mice by Kon, Kazuyoshi, Arai, Kumiko, Uchiyama, Akira, Fukada, Hiroo, Sato, Toshifumi, Yamashina, Shunhei, Ikejima, Kenichi

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WED-415 - Type I NKT cells are involved in exacerbation of steatohepatitis in aged mice by Kon, Kazuyoshi, Arai, Kumiko, Uchiyama, Akira, Fukada, Hiroo, Sato, Toshifumi, Yamashina, Shunhei, Ikejima, Kenichi

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Gender-specific development of experimental autoimmune cholangitis induced by double-stranded RNA by Someya, Shunin, Uchiyama, Akira, Arai, Kumiko, Kon, Kazuyoshi, Yamashina, Shunhei, Watanabe, Sumio, Ikejima, Kenichi

“…Here we investigated the gender difference in murine cholangitis resembling human primary biliary cholangitis (PBC) caused by synthetic double-stranded RNA,…”
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Sa1587 DOWNREGULATION OF FATTY ACID DESATURASE 2 EXACERBATES MURINE STEATOHEPATITIS CAUSED BY HIGH-FAT AND HIGH-CHOLESTEROL DIET by Kon, Kazuyoshi, Lee-Okada, Hyeon-Cheol, Arai, Kumiko, Uchiyama, Akira, Sato, Toshifumi, Fukada, Hiroo, Yokomizo, Takehiko, Yamashina, Shunhei, Ikejima, Kenichi

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Amino acid glycine suppresses steatohepatitis and tumorigenesis in hepatocyte-specific phosphatase and tensin homolog knockout mice by Kon, Kazuyoshi, Arai, Kumiko, Uchiyama, Akira, Fukada, Hiroo, Sato, Toshifumi, Morinaga, Maki, Fukuhara, Kyoko, Yaginuma, Reiko, Yamashina, Shunhei, Ikejima, Kenichi

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Tu1298: TYPE I AND II NATURAL KILLER T CELLS ARE INVOLVED IN THE DEVELOPMENT OF STEATOHEPATITIS IN ELDER MICE by Kon, Kazuyoshi, Nakadera, Eisuke, Arai, Kumiko, Uchiyama, Akira, Fukada, Hiroo, Sato, Toshifumi, Yaginuma, Reiko, Fukuhara, Kyoko, Yamashina, Shunhei, Ikejima, Kenichi

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Su1544 – Aging Causes the Exacerbation of Dietary Steatohepatitis Accompanied by Muscle Weakness in Mice by Ishizuka, Kei, Kon, Kazuyoshi, Arai, Kumiko, Uchiyama, Akira, Yamashina, Shunhei, Ikejima, Kenichi

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