Characterization of focal liver lesions using sulphur hexafluoride microbubble contrast-enhanced ultrasonography

Characterization of focal liver lesions using sulphur hexafluoride microbubble contrast-enhanced ultrasonography

Background Focal hepatic lesions incidentally detected during ultrasound usually need further step for proper characterization. The aim of this study was to highlight the efficacy of microbubble contrast-enhanced ultrasonography (CEUS) in characterization of focal liver lesions. This prospective stu...

Full description

Saved in:
Bibliographic Details
Published in:Egyptian journal of radiology and nuclear medicine Vol. 52; no. 1; pp. 7 - 11
Main Authors: Mansour, Mohamed Gamal El-Din, Kader, Mona Hussein Abdel, Arafa, Hanan Mahmoud, Ali, Susan Adil
Format: Journal Article
Language:English
Published: Cairo Springer 05-01-2021
Springer Nature B.V
SpringerOpen
Subjects:
Biopsy
Contrast media
Contrast-enhanced ultrasonography
Females
Histochemistry
Liver
Liver cancer
Liver cirrhosis
Liver focal lesions
Medical research
Medicine, Experimental
Metastasis
Microbubble contrast agents
Patients
Sulfur hexafluoride
Ultrasonic imaging
Ultrasound imaging
Veins & arteries
United States > US
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Background Focal hepatic lesions incidentally detected during ultrasound usually need further step for proper characterization. The aim of this study was to highlight the efficacy of microbubble contrast-enhanced ultrasonography (CEUS) in characterization of focal liver lesions. This prospective study was conducted on 60 patients presented with hepatic focal lesions in the period from January 2019 to June 2020. CEUS studies were performed after a baseline conventional ultrasound with the same machine by the same operator. The ultrasound contrast agent used is second-generation US contrast agent. The enhancement patterns of the hepatic lesions were studied during the vascular phases up to 5 min and the data were correlated with histopathology, triphasic contrast-enhanced CT, and clinical follow-up. Results CEUS demonstrated a sensitivity of 94.2%, specificity of 88.9%, positive predictive value of 91%, negative predictive value of 94.1%, and accuracy of 92.3% for characterization of hepatic focal lesions, compared to a sensitivity of 100%, specificity of 81.8%, positive predictive value of 84%, negative predictive value of 100%, and accuracy of 90.7% for triphasic CT. Conclusion CEUS is an effective tool in characterization of HFLs and recommended as a second diagnostic step after conventional ultrasound to immediately establish the diagnosis especially in patients with contraindications to CECT.
ISSN:0378-603X
2090-4762
DOI:10.1186/s43055-020-00374-0