Search Results - "Araúzo‐Bravo, Marcos"
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Induction of Pluripotency in Adult Unipotent Germline Stem Cells
Published in Cell stem cell (02-07-2009)“…Mouse and human stem cells with features similar to those of embryonic stem cells have been derived from testicular cells. Although pluripotent stem cells have…”
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Universal Cardiac Induction of Human Pluripotent Stem Cells in Two and Three‐Dimensional Formats: Implications for In Vitro Maturation
Published in Stem cells (Dayton, Ohio) (01-05-2015)“…Directed cardiac differentiation of human pluripotent stem cells (hPSCs) enables disease modeling, investigation of human cardiogenesis, as well as large‐scale…”
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Oct4 and Hnf4α-induced hepatic stem cells ameliorate chronic liver injury in liver fibrosis model
Published in PloS one (12-08-2019)“…Direct conversion from fibroblasts to generate hepatocyte like-cells (iHeps) bypassing the pluripotent state has been described in previous reports as an…”
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Stepwise Clearance of Repressive Roadblocks Drives Cardiac Induction in Human ESCs
Published in Cell stem cell (03-03-2016)“…Cardiac induction requires stepwise integration of BMP and WNT pathway activity. Human embryonic stem cells (hESCs) are developmentally and clinically relevant…”
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Transcription factor TFAP2C regulates major programs required for murine fetal germ cell maintenance and haploinsufficiency predisposes to teratomas in male mice
Published in PloS one (13-08-2013)“…Maintenance and maturation of primordial germ cells is controlled by complex genetic and epigenetic cascades, and disturbances in this network lead to either…”
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Single-cell RNA sequencing of human non-hematopoietic bone marrow cells reveals a unique set of inter-species conserved biomarkers for native mesenchymal stromal cells
Published in Stem cell research & therapy (30-08-2023)“…Background Native bone marrow (BM) mesenchymal stem/stromal cells (BM-MSCs) participate in generating and shaping the skeleton and BM throughout the lifespan…”
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Galunisertib downregulates mutant type I collagen expression and promotes MSCs osteogenesis in pediatric osteogenesis imperfecta
Published in Biomedicine & pharmacotherapy (01-06-2024)“…Qualitative alterations in type I collagen due to pathogenic variants in the COL1A1 or COL1A2 genes, result in moderate and severe Osteogenesis Imperfecta…”
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TET3 regulates terminal cell differentiation at the metabolic level
Published in Nature communications (18-11-2024)“…TET-family members play a critical role in cell fate commitment. Indeed, TET3 is essential to postnatal development due to yet unknown reasons. To define TET3…”
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Reprogramming of two somatic nuclei in the same ooplasm leads to pluripotent embryonic stem cells
Published in Stem cells (Dayton, Ohio) (01-11-2013)“…The conversion of the nuclear program of a somatic cell from a differentiated to an undifferentiated state can be accomplished by transplanting its nucleus to…”
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Computational Biology Methods for Characterization of Pluripotent Cells
Published in Methods in molecular biology (Clifton, N.J.) (01-01-2016)“…Pluripotent cells are a powerful tool for regenerative medicine and drug discovery. Several techniques have been developed to induce pluripotency, or to…”
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Conversion of adult mouse unipotent germline stem cells into pluripotent stem cells
Published in Nature protocols (01-05-2010)“…Germline stem cells (GSCs), often called spermatogonial stem cells, are unipotent stem cells that can give rise only to gametes. Under defined culture…”
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Germ cell nuclear factor regulates gametogenesis in developing gonads
Published in PloS one (20-08-2014)“…Expression of germ cell nuclear factor (GCNF; Nr6a1), an orphan member of the nuclear receptor gene family of transcription factors, during gastrulation and…”
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Reprogramming to pluripotency through a somatic stem cell intermediate
Published in PloS one (27-12-2013)“…Transcription factor-based reprogramming can lead to the successful switching of cell fates. We have recently reported that mouse embryonic fibroblasts (MEFs)…”
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Revised roles of ISL1 in a hES cell-based model of human heart chamber specification
Published in eLife (16-01-2018)“…The transcription factor ISL1 is thought to be key for conveying the multipotent and proliferative properties of cardiac precursor cells. Here, we investigate…”
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The K2P‐channel TASK1 affects Oligodendroglial differentiation but not myelin restoration
Published in Glia (01-05-2019)“…In multiple sclerosis, demyelination occurs as a consequence of chronic autoimmunity in the central nervous system causing progressive neurological impairment…”
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Sox2 Level Is a Determinant of Cellular Reprogramming Potential
Published in PloS one (18-06-2013)“…Epiblast stem cells (EpiSCs) and embryonic stem cells (ESCs) differ in their in vivo differentiation potential. While ESCs form teratomas and efficiently…”
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Author Correction: PR-LncRNA signature regulates glioma cell activity through expression of SOX factors
Published in Scientific reports (20-06-2022)Get full text
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A collection of integration-free iPSCs derived from Parkinson's disease patients carrying mutations in the GBA1 gene
Published in Stem cell research (01-07-2019)“…Mutations in the GBA1 gene, which encodes the lysosomal enzyme Glucocerebrosidase1 are major risk factors for Parkinson's disease (PD) and dementia with Lewy…”
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Generation of an integration-free iPSC line, ICCSICi005-A, derived from a Parkinson's disease patient carrying the L444P mutation in the GBA1 gene
Published in Stem cell research (01-10-2019)“…The L444P mutation in the GBA1 gene which encodes β-glucocerebrosidase-1, is a major risk factor for developing Parkinson's disease (PD) and dementia with Lewy…”
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Effect of cra gene knockout together with edd and iclR genes knockout on the metabolism in Escherichia coli
Published in Archives of microbiology (01-11-2008)“…To elucidate the physiological adaptation of Escherichia coli due to cra gene knockout, a total of 3,911 gene expressions were investigated by DNA microarray…”
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