Effect of Topical Instillation of Pegaptanib Sodium Upon Inflammatory Corneal Neovascularization in Rabbits

To evaluate the effect of topical instillation of pegaptanib sodium upon inflammatory angiogenesis induced in the rabbit cornea by alkaline cauterization. Inflammatory angiogenesis was induced by alkaline (sodium hydroxide) cauterization in the corneas of 29 male New Zealand rabbits. The animals wer...

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Bibliographic Details
Published in:	Journal of ocular pharmacology and therapeutics Vol. 37; no. 5; p. 277
Main Authors:	Andrade, Newton, Crispim Ribeiro, Joao, Araújo E Silva, Paulo Matheus, Savio, Domingos, Fechine, Francisco Vagnaldo, de Moraes, Manoel Odorico
Format:	Journal Article
Language:	English
Published:	United States 01-06-2021
Subjects:	Administration, Topical Angiogenesis Inhibitors - administration & dosage Angiogenesis Inhibitors - pharmacology Angiogenesis Inhibitors - therapeutic use Animals Anti-Inflammatory Agents - administration & dosage Anti-Inflammatory Agents - pharmacology Aptamers, Nucleotide - administration & dosage Aptamers, Nucleotide - pharmacology Aptamers, Nucleotide - therapeutic use Caustics - administration & dosage Caustics - adverse effects Cornea - pathology Corneal Injuries - chemically induced Corneal Neovascularization - chemically induced Disease Models, Animal Inflammation - diagnosis Inflammation - drug therapy Instillation, Drug Male Neovascularization, Pathologic - drug therapy Prednisolone - administration & dosage Prednisolone - pharmacology Rabbits Sodium Hydroxide - administration & dosage Sodium Hydroxide - adverse effects Treatment Outcome Vascular Endothelial Growth Factor A - antagonists & inhibitors treatment prednisolone pegaptanib angiogenesis vascular endothelial growth factor inflammatory corneal neovascularization
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Summary:	To evaluate the effect of topical instillation of pegaptanib sodium upon inflammatory angiogenesis induced in the rabbit cornea by alkaline cauterization. Inflammatory angiogenesis was induced by alkaline (sodium hydroxide) cauterization in the corneas of 29 male New Zealand rabbits. The animals were divided into 4 groups: a control group treated with 0.5% carboxymethylcellulose sodium eye drops, a group treated with 1.0% prednisolone acetate eye drops, a group treated with 0.5% pegaptanib sodium diluted in 15 mL 0.5% carboxymethylcellulose sodium, and a group treated with 1.0% pegaptanib sodium diluted in 15 mL 0.5% carboxymethylcellulose sodium. After cauterization, eye drops were administered every 12 hours for 21 days. The animals were evaluated every 3 days after cauterization, and the newly formed vessels were quantified from photographs. The treatment effectiveness was analyzed with 3 parameters of antiangiogenic response: neovascularization area (NA), total vascular length (TVL), and number of blood vessels (BVN). Average NA, TVL, and BVN values were significantly higher in both pegaptanib groups than in the prednisolone group. A nonstatistically significant reduction in parameters on days 18 and 21 was the minimum achieved in both pegaptanib groups. The efficacy of the treatments in relation to the control was significantly greater in the prednisolone group than in the 0.5% pegaptanib group or the 1.0% pegaptanib group ( < 0.001). Topical instillation of 0.5% and 1.0% pegaptanib sodium diluted in 15 mL 0.5% carboxymethylcellulose sodium had no inhibitory effect on corneal neovascularization in this rabbit model.
ISSN:	1557-7732
DOI:	10.1089/jop.2020.0010