Synthesis, Characterization, and NO Release Study of the cis- and trans-[Ru(Bpy)2(SO3)(NO)]+ Complexes

Aiming at the development of novel NO donors, the synthesis and reactivity of the trans‐[Ru(bpy)2(SO3)(NO)](PF6) and cis‐[Ru(bpy)2(L)(NO)](PF6)n complexes (L = imidazole, isonicotinamide, or sulfite ions) were investigated. The complexes were characterized and the NO release capabilities were evalua...

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Bibliographic Details
Published in:	European Journal of Inorganic Chemistry Vol. 2006; no. 10; pp. 2020 - 2026
Main Authors:	Silva, Francisco O. N., Araújo, Sérgio X. B., Holanda, Alda K. M., Meyer, Emerson, Sales, Francisco A. M., Diógenes, Izaura C. N., Carvalho, Idalina M. M., Moreira, Ícaro S., Lopes, Luiz G. F.
Format:	Book Review Journal Article
Language:	English
Published:	Weinheim WILEY-VCH Verlag 01-05-2006 WILEY‐VCH Verlag
Subjects:	Bioinorganic chemistry Drug design Nitrogen oxides Ruthenium
Online Access:	Get full text
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Summary:	Aiming at the development of novel NO donors, the synthesis and reactivity of the trans‐[Ru(bpy)2(SO3)(NO)](PF6) and cis‐[Ru(bpy)2(L)(NO)](PF6)n complexes (L = imidazole, isonicotinamide, or sulfite ions) were investigated. The complexes were characterized and the NO release capabilities were evaluated. The rate constant for NO dissociation for the cis‐[Ru(bpy)2(SO3)(NO)]+ complex is k = 2.0·10–3 s–1. The cis and trans‐ [Ru(bpy)2(SO3)(NO)]+ complexes showed promising physical‐chemical properties towards nitric oxide generation, and great stability towards hydroxide attack in the 2.0–9.0 pH range. The reduction potential of the {RuNO}6/7 process of the cis and trans‐[Ru(bpy)2(SO3)NO]+ complexes (E1/2 =–0.14 and –0.34 V vs. Ag/AgCl) is appropriated for reduction in vivo by biological reducing agents, with consequent NO release. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2006)
Bibliography:	istex:D91155EC904E98EAFA4A41D03962F7929A83CE96 ark:/67375/WNG-DCTRTZ7F-Z ArticleID:EJIC200500871
ISSN:	1434-1948 1099-0682
DOI:	10.1002/ejic.200500871