Botulinum toxin A in complex incisional hernia repair: a systematic review
Purpose To evaluate the safety, efficacy, and short and long-term postoperative results of using BTA. Methods We conducted a systematic review following the recommendations of the PRISMA method. We systematically reviewed the MEDLINE/PubMed and SCOPUS electronic databases for studies published betwe...
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| Published in: | Hernia : the journal of hernias and abdominal wall surgery Vol. 28; no. 3; pp. 665 - 676 |
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| Main Authors: | , , , , , |
| Format: | Journal Article |
| Language: | English |
| Published: |
Paris
Springer Paris
01-06-2024
Springer Nature B.V |
| Subjects: | |
| Online Access: | Get full text |
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| Summary: | Purpose
To evaluate the safety, efficacy, and short and long-term postoperative results of using BTA.
Methods
We conducted a systematic review following the recommendations of the PRISMA method. We systematically reviewed the MEDLINE/PubMed and SCOPUS electronic databases for studies published between January 2010 and September 2021. This systematic review was registered in PROSPERO, with registration number CRD42021252445.
Results
After applying the selection criteria, 11 relevant articles were selected. The total sample size was 1058 patients. Most studies aimed to assess the rate of fascial closure, followed by the rate of recurrence and reporting of postoperative complications, as well as the need for the components separation technique (CST). None of the studies reported serious complications from using BTA. Regarding fascial closure, all articles had rates above 75%, except for one. Surgical site events ranged between 19% and 29.4%. No recurrence in the group that used BTA was recorded in five studies. The other articles reported recurrence rates ranging from 6.4 to 11.4% in the groups that received BTA. The studies had varying follow-up times ranging from 1 to 49 months, with a mean of 18.6 months (± 11.2).
Conclusion
This review described most of the key points about the preoperative use of BTA in hernia repair. It can be concluded that the use of BTA is a safe and effective practice that promotes good short and long-term results. However, the limitations of the current literature prevent more accurate conclusions on the subject. |
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| Bibliography: | ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Undefined-1 ObjectType-Feature-3 ObjectType-Review-4 content type line 23 |
| ISSN: | 1248-9204 1265-4906 1248-9204 |
| DOI: | 10.1007/s10029-023-02892-y |