Search Results - "Aqil, Rehan"

Preclinical trial of a MAP4K4 inhibitor to reduce infarct size in the pig: does cardioprotection in human stem cell-derived myocytes predict success in large mammals? by te Lintel Hekkert, Maaike, Newton, Gary, Chapman, Kathryn, Aqil, Rehan, Downham, Robert, Yan, Robert, Merkus, Daphne, Whitlock, Gavin, Lane, Charlotte A. L., Cawkill, Darren, Perrior, Trevor, Duncker, Dirk J., Schneider, Michael D.

“…Reducing infarct size (IS) by interfering with mechanisms for cardiomyocyte death remains an elusive goal. DMX-5804, a selective inhibitor of the…”
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Small Molecule Inhibitors of the Neuropilin-1 Vascular Endothelial Growth Factor A (VEGF-A) Interaction by Jarvis, Ashley, Allerston, Charles K, Jia, Haiyan, Herzog, Birger, Garza-Garcia, Acely, Winfield, Natalie, Ellard, Katie, Aqil, Rehan, Lynch, Rosemary, Chapman, Chris, Hartzoulakis, Basil, Nally, James, Stewart, Mark, Cheng, Lili, Menon, Malini, Tickner, Michelle, Djordjevic, Snezana, Driscoll, Paul C, Zachary, Ian, Selwood, David L

“…We report the molecular design and synthesis of EG00229, 2, the first small molecule ligand for the VEGF-A receptor neuropilin 1 (NRP1) and the structural…”
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Characterization of a Bicyclic Peptide Neuropilin-1 (NP-1) Antagonist (EG3287) Reveals Importance of Vascular Endothelial Growth Factor Exon 8 for NP-1 Binding and Role of NP-1 in KDR Signaling by Jia, Haiyan, Bagherzadeh, Azadeh, Hartzoulakis, Basil, Jarvis, Ashley, Löhr, Marianne, Shaikh, Shaheda, Aqil, Rehan, Cheng, Lili, Tickner, Michelle, Esposito, Diego, Harris, Richard, Driscoll, Paul C., Selwood, David L., Zachary, Ian C.

“…Neuropilin-1 (NP-1) is a receptor for vascular endothelial growth factor-A165 (VEGF-A165) in endothelial cells. To define the role of NP-1 in the biological…”
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[(Eta-C5H4R)Fe(CO)2X], X = Cl, Br, I, NO3, CO2Me and [(eta-C5H4R)Fe(CO)3]+, R = (CH2)nCO2Me (n = 0-2), and CO2CH2CH2OH: a new group of CO-releasing molecules by Scapens, David, Adams, Harry, Johnson, Tony R, Mann, Brian E, Sawle, Philip, Aqil, Rehan, Perrior, Trevor, Motterlini, Roberto

“…A new group of CO-releasing molecules, CO-RMs, based on cyclopentadienyl iron carbonyls have been identified. X-Ray structures have been determined for…”
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MAP4K4 Inhibition Promotes Survival of Human Stem Cell-Derived Cardiomyocytes and Reduces Infarct Size In Vivo by Fiedler, Lorna R., Chapman, Kathryn, Xie, Min, Maifoshie, Evie, Jenkins, Micaela, Golforoush, Pelin Arabacilar, Bellahcene, Mohamed, Noseda, Michela, Faust, Dörte, Jarvis, Ashley, Newton, Gary, Paiva, Marta Abreu, Harada, Mutsuo, Stuckey, Daniel J., Song, Weihua, Habib, Josef, Narasimhan, Priyanka, Aqil, Rehan, Sanmugalingam, Devika, Yan, Robert, Pavanello, Lorenzo, Sano, Motoaki, Wang, Sam C., Sampson, Robert D., Kanayaganam, Sunthar, Taffet, George E., Michael, Lloyd H., Entman, Mark L., Tan, Tse-Hua, Harding, Sian E., Low, Caroline M.R., Tralau-Stewart, Catherine, Perrior, Trevor, Schneider, Michael D.

“…Heart disease is a paramount cause of global death and disability. Although cardiomyocyte death plays a causal role and its suppression would be logical, no…”
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MAP4K4 Inhibition Promotes Survival of Human Stem Cell-Derived Cardiomyocytes and Reduces Infarct Size In Vivo by Fiedler, Lorna R., Chapman, Kathryn, Xie, Min, Maifoshie, Evie, Jenkins, Micaela, Golforoush, Pelin Arabacilar, Bellahcene, Mohamed, Noseda, Michela, Faust, Dörte, Jarvis, Ashley, Newton, Gary, Paiva, Marta Abreu, Harada, Mutsuo, Stuckey, Daniel J., Song, Weihua, Habib, Josef, Narasimhan, Priyanka, Aqil, Rehan, Sanmugalingam, Devika, Yan, Robert, Pavanello, Lorenzo, Sano, Motoaki, Wang, Sam C., Sampson, Robert D., Kanayaganam, Sunthar, Taffet, George E., Michael, Lloyd H., Entman, Mark L., Tan, Tse-Hua, Harding, Sian E., Low, Caroline M.R., Tralau-Stewart, Catherine, Perrior, Trevor, Schneider, Michael D.

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N-Terminal Modification of VEGF-A C Terminus-Derived Peptides Delineates Structural Features Involved in Neuropilin-1 Binding and Functional Activity by Jia, Haiyan, Aqil, Rehan, Cheng, Lili, Chapman, Chris, Shaikh, Shaheda, Jarvis, Ashley, Chan, A. W. Edith, Hartzoulakis, Basil, Evans, Ian M., Frolov, Antonina, Martin, John, Frankel, Paul, Djordevic, Snezana, Zachary, Ian C., Selwood, David L.

“…The interaction between VEGF‐A and its neuropilin (NRP) receptors mediates a number of important biological effects. NRP1 and the related molecule NRP2 are…”
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Observations on the regio- and stereoselective trapping of organozinc carbenoids by acetoxybutadienes: a useful route to functionalised vinylcyclopropanes by Aqil, Rehan, Motherwell, William B., Roberts, Lee R., Russell, C.Adam

“…Regiospecific trapping of organozinc carbenoids generated from carbonyl compounds with Z-1-acetoxybutadiene provides a useful preparative route to…”
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Studies on the generation and reactivity of metal carbenoids by Aqil, Rehan

“…This thesis concerns the generation of metal carbenoids, in particular organozinc carbenoids, and their subsequent reactions, such as C-H insertion reactions…”
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