Search Results - "Aqaqe, Nasma"

Spironolactone inhibits the growth of cancer stem cells by impairing DNA damage response by Gold, Ayala, Eini, Lital, Nissim-Rafinia, Malka, Viner, Ruth, Ezer, Shlomit, Erez, Keren, Aqaqe, Nasma, Hanania, Rotem, Milyavsky, Michael, Meshorer, Eran, Goldberg, Michal

“…The cancer stem cell (CSC) model suggests that a subpopulation of cells within the tumor, the CSCs, is responsible for cancer relapse and metastasis formation…”
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A novel method for detecting the cellular stemness state in normal and leukemic human hematopoietic cells can predict disease outcome and drug sensitivity by Yassin, Muhammad, Aqaqe, Nasma, Yassin, Abed Alkader, van Galen, Peter, Kugler, Eitan, Bernstein, Bradley E., Koren-Michowitz, Maya, Canaani, Jonathan, Nagler, Arnon, Lechman, Eric R., Dick, John E., Wienholds, Erno, Izraeli, Shai, Milyavsky, Michael

“…Acute leukemia is an aggressive blood malignancy with low survival rates. A high expression of stem-like programs in leukemias predicts poor prognosis and is…”
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The NCOR-HDAC3 co-repressive complex modulates the leukemogenic potential of the transcription factor ERG by Kugler, Eitan, Madiwale, Shreyas, Yong, Darren, Thoms, Julie A. I., Birger, Yehudit, Sykes, David B., Schmoellerl, Johannes, Drakul, Aneta, Priebe, Valdemar, Yassin, Muhammad, Aqaqe, Nasma, Rein, Avigail, Fishman, Hila, Geron, Ifat, Chen, Chun-Wei, Raught, Brian, Liu, Qiao, Ogana, Heather, Liedke, Elisabeth, Bourquin, Jean-Pierre, Zuber, Johannes, Milyavsky, Michael, Pimanda, John, Privé, Gilbert G., Izraeli, Shai

“…The ERG (ETS-related gene) transcription factor is linked to various types of cancer, including leukemia. However, the specific ERG domains and co-factors…”
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Cancer-selective cytotoxic Ca2+ overload in acute myeloid leukemia cells and attenuation of disease progression in mice by synergistically acting polyphenols curcumin and carnosic acid by Pesakhov, Stella, Nachliely, Matan, Barvish, Zeev, Aqaqe, Nasma, Schwartzman, Bar, Voronov, Elena, Sharoni, Yoav, Studzinski, George P, Fishman, Daniel, Danilenko, Michael

“…Acute myeloid leukemia (AML) is an aggressive hematologic malignancy characterized by extremely heterogeneous molecular and biologic abnormalities that hamper…”
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Attenuated DNA damage responses and increased apoptosis characterize human hematopoietic stem cells exposed to irradiation by Biechonski, Shahar, Olender, Leonid, Zipin-Roitman, Adi, Yassin, Muhammad, Aqaqe, Nasma, Marcu-Malina, Victoria, Rall-Scharpf, Melanie, Trottier, Magan, Meyn, M. Stephen, Wiesmüller, Lisa, Beider, Katia, Raz, Yael, Grisaru, Dan, Nagler, Arnon, Milyavsky, Michael

“…Failure to precisely repair DNA damage in self-renewing Hematopoietic Stem and early Progenitor Cells (HSPCs) can disrupt normal hematopoiesis and promote…”
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Characterization of gene regulatory networks responsible for human leukemia cells regeneration after genotoxic stress by Aqaqe, Nasma, Milyavsky, Michael

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An ERG Enhancer-Based Reporter Identifies Leukemia Cells with Elevated Leukemogenic Potential Driven by ERG-USP9X Feed-Forward Regulation by Aqaqe, Nasma, Yassin, Muhammad, Yassin, Abed Alkader, Ershaid, Nour, Katz-Even, Chen, Zipin-Roitman, Adi, Kugler, Eitan, Lechman, Eric R, Gan, Olga I, Mitchell, Amanda, Dick, John E, Izraeli, Shai, Milyavsky, Michael

“…Acute leukemia is a rapidly progressing blood cancer with low survival rates. Unfavorable prognosis is attributed to insufficiently characterized…”
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Quercetin alters the DNA damage response in human hematopoietic stem and progenitor cells via TopoII‐ and PI3K‐dependent mechanisms synergizing in leukemogenic rearrangements by Biechonski, Shahar, Gourevich, Dana, Rall, Melanie, Aqaqe, Nasma, Yassin, Muhammad, Zipin‐Roitman, Adi, Trakhtenbrot, Luba, Olender, Leonid, Raz, Yael, Jaffa, Ariel J., Grisaru, Dan, Wiesmuller, Lisa, Elad, David, Milyavsky, Michael

“…Quercetin (Que) is an abundant flavonoid in the human diet and high‐concentration food supplement with reported pro‐ and anti‐carcinogenic activities…”
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ERG enhancer derived regulatory sequences define “stem-like” cells in human leukemia by Milyavsky, Michael, Yassin, Muhammad, Aqaqe, Nasma, Yassin, Abd, Shlush, Liran, Koren-Michowitz, Maya

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ERG ENHANCER-BASED REPORTER IDENTIFIES LEUKEMIA CELLS WITH ELEVATED LEUKEMOGENIC POTENTIAL DRIVEN BY ERG-USP9X FEED-FORWARD REGULATION by Milyavsky, Michael, Aqaqe, Nasma, Yassin, Muhammad, Yassin, Abed, Ershaid, Nour, Katz-Even, Chen, Zipin-Roitman, Adi, Kugler, Eitan, Lechman, Eric, Gan, Olga, Mitchell, Amanda, Dick, John, Izraeli, Shai

“…Acute leukemia is a rapidly progressing blood cancer with low survival rates. Unfavorable prognosis is attributed to the insufficiently characterized…”
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Distinct Roles of CHK2 and Cell Death in Suppressing Oncogenic Potential of Tandem DNA Breaks in Human Hematopoietic Stem Cells by Biechonski, Shahar, Yassin, Muhammad, Aqaqe, Nasma, Olender, Leonid, Rall, Melanie, Wiesmüller, Lisa, Raz, Yael, Beider, Katia, Nagler, Arnon, Milyavsky, Michael

“…DNA double strand breaks (DSBs) are the most dangerous genomic lesions that can be induced by endogenous and exogenous sources. DNA damage response determines…”
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Attenuated DNA Damage Responses and Increased Apoptosis Characterize Human Hematopoietic Stem Cells Exposed to Irradiation by Milyavsky, Michael, Biechonski, Shahar, Olender, Leonid, Zipin-Roitman, Adi, Yassin, Muhammad, Aqaqe, Nasma, Marcu-Malina, Victoria, Rall, Melanie, Wiesmuller, Lisa, Beider, Katia, Raz, Yael, Grisaru, Dan, Nagler, Arnon

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3115 - ¬¬Attenuated DNA Damage Responses and Increased Apoptosis Characterize Human Hematopoietic Stem Cells Exposed to Irradiation by Milyavsky, Michael, Biechonski, Shahar, Olender, Leonid, Zipin-Roitman, Adi, Yassin, Muhammad, Aqaqe, Nasma, Marcu-Malina, Victoria, Rall, Melanie, Wiesmuller, Lisa, Beider, Katia, Raz, Yael, Grisaru, Dan, Nagler, Arnon

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Development of ERG-Enhancer Fluorescent Reporter System to Decipher Functional Heterogeneity in Leukemia by Milyavsky, Michael, Yassin, Muhammad, Aqaqe, Nasma, Yassin, Abd Alkader, Zipin-Roitman, Adi, Biechonski, Shahar, Van, Peter, Kugler, Eitan, Bernstein, Bradley, Dick, John, Wienholds, Erno, Izraeli, Shai

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3116 - Development of ERG-Enhancer Fluorescent Reporter System to Decipher Functional Heterogeneity in Leukemia by Milyavsky, Michael, Yassin, Muhammad, Aqaqe, Nasma, Yassin, Abd Alkader, Zipin-Roitman, Adi, Biechonski, Shahar, Van, Peter, Kugler, Eitan, Bernstein, Bradley, Dick, John, Wienholds, Erno, Izraeli, Shai

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AML-131 ERG: From a Fortuitous Discovery to Potential Treatment for AML by Kugler, Eitan, Madiwale, Shreyas, Yong, Darren, Birger, Yehudit, Thoms, Julie AI, Sykes, David B, Yassin, Muhammad, Aqaqe, Nasma, Rein, Avigail, Fishman, Hila, Geron, Ifat, Chen, Chun-Wei, Raught, Brian, Liu, Qiao, Milyavsky, Michael, Pimanda, John, Privé, Gilbert G, Izraeli, Shai

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Poster: AML-131 ERG: From a Fortuitous Discovery to Potential Treatment for AML by Kugler, Eitan, Madiwale, Shreyas, Yong, Darren, Birger, Yehudit, Thoms, Julie AI, Sykes, David B, Yassin, Muhammad, Aqaqe, Nasma, Rein, Avigail, Fishman, Hila, Geron, Ifat, Chen, Chun-Wei, Raught, Brian, Liu, Qiao, Milyavsky, Michael, Pimanda, John, Privé, Gilbert G, Izraeli, Shai

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Quercetin alters the DNA damage response in human hematopoietic stem and progenitor cells via T opo II ‐ and PI 3 K ‐dependent mechanisms synergizing in leukemogenic rearrangements by Biechonski, Shahar, Gourevich, Dana, Rall, Melanie, Aqaqe, Nasma, Yassin, Muhammad, Zipin‐Roitman, Adi, Trakhtenbrot, Luba, Olender, Leonid, Raz, Yael, Jaffa, Ariel J., Grisaru, Dan, Wiesmuller, Lisa, Elad, David, Milyavsky, Michael

“…Quercetin (Que) is an abundant flavonoid in the human diet and high‐concentration food supplement with reported pro‐ and anti‐carcinogenic activities…”
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SMYD2 lysine methyltransferase regulates leukemia cell growth and regeneration after genotoxic stress by Zipin-Roitman, Adi, Aqaqe, Nasma, Yassin, Muhammad, Biechonski, Shahar, Amar, Mariam, van Delft, Mark F, Gan, Olga I, McDermott, Sean P, Buzina, Alla, Ketela, Troy, Shlush, Liran, Xie, Stephanie, Voisin, Veronique, Moffat, Jason, Minden, Mark D, Dick, John E, Milyavsky, Michael

“…The molecular determinants governing escape of Acute Myeloid Leukemia (AML) cells from DNA damaging therapy remain poorly defined and account for therapy…”
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Abstract 2184: The roles of intracellular calcium and ER stress in the synergistic apoptotic effect of the plant polyphenols curcumin and carnosic acid in acute myeloid leukemia cells by Pesakhov, Stella, Aqaqe, Nasma, Studzinski, George P., Fishman, Daniel, Danilenko, Michael

“…Abstract Failure to cure acute myeloid leukemia (AML) by conventional chemotherapy still represents a challenge for hematological oncology. Small molecule…”
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