Acute bilateral mydriasis associated with anti-GQ1b antibody

Acute bilateral mydriasis associated with anti-GQ1b antibody

Abstract Miller Fisher syndrome (MFS) is an autoimmune neuropathy characterized by external ophthalmoplegia, ataxia and areflexia. Mydriasis is present in 35% of typical MFS. We report five patients with acute bilateral mydriasis, either isolated or associated with external ophthalmoplegia for which...

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Bibliographic Details
Published in:Journal of clinical neuroscience Vol. 17; no. 4; pp. 514 - 515
Main Authors: Fleury, V, Aqallal, A, Lagrange, E, Besson, G, Caudie, C
Format: Journal Article
Language:English
Published: Scotland Elsevier Ltd 01-04-2010
Subjects:
Adolescent
Adult
Anti-GQ1b antibody
Autoantibodies - blood
Autoantigens - immunology
Female
Gangliosides - immunology
Humans
Male
Middle Aged
Miller Fisher syndrome
Miller Fisher Syndrome - blood
Miller Fisher Syndrome - complications
Miller Fisher Syndrome - immunology
Mydriasis
Mydriasis - etiology
Neurology
Ophthalmoplegia - etiology
Anti-GQ1b antibody
Miller Fisher syndrome
Mydriasis
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Summary:Abstract Miller Fisher syndrome (MFS) is an autoimmune neuropathy characterized by external ophthalmoplegia, ataxia and areflexia. Mydriasis is present in 35% of typical MFS. We report five patients with acute bilateral mydriasis, either isolated or associated with external ophthalmoplegia for which the presumed diagnosis of “atypical MFS” was confirmed by the positivity of anti-GQ1b antibodies. Acute bilateral mydriasis raises important differential diagnoses in clinical practice. This report demonstrates that acute mydriasis can be autoimmune mediated and that anti-GQ1b antibodies are useful to confirm the diagnosis in unexplained cases.
Bibliography:ObjectType-Case Study-2
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ISSN:0967-5868
1532-2653
DOI:10.1016/j.jocn.2009.06.030