Search Results - "Appleton, I."

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    Regional variations and age-related changes in nitric oxide synthase and arginase in the sub-regions of the hippocampus by Liu, P, Smith, P.F, Appleton, I, Darlington, C.L, Bilkey, D.K

    Published in Neuroscience (01-01-2003)
    “…l-arginine can be metabolised by nitric oxide synthase (NOS) with the formation of l-citrulline and nitric oxide (NO), or arginase with the production of…”
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    Journal Article
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    Inducible Isoforms of Cyclooxygenase and Nitric-Oxide Synthase in Inflammation by Vane, John R., Mitchell, Jane A., Appleton, Ian, Tomlinson, Annette, Bishop-Bailey, David, Croxtall, Jamie, Willoughby, Derek A.

    “…Cyclooxygenase (COX) converts arachidonic acid to prostaglandin H2, which is further metabolized to prostanoids. Two isoforms of COX exist: a constitutive…”
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    Journal Article
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    Age-related changes in nitric oxide synthase and arginase in the rat prefrontal cortex by Liu, P, Smith, P.F, Appleton, I, Darlington, C.L, Bilkey, D.K

    Published in Neurobiology of aging (01-04-2004)
    “…Increasing evidence suggests that nitric oxide (NO), generated by nitric oxide synthase (NOS) from l-arginine, plays an important role in the ageing process…”
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    Journal Article
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    Potential involvement of NOS and arginase in age-related behavioural impairments by Liu, P., Smith, P.F., Appleton, I., Darlington, C.L., Bilkey, D.K.

    Published in Experimental gerontology (01-08-2004)
    “…The present study investigated age-related changes in nitric oxide synthase (NOS) and arginase, which shares a substrate with NOS, in the hippocampus and…”
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    Journal Article
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    The role of nitric oxide synthase isoforms and arginase in the pathogenesis of diabetic foot ulcers : possible modulatory effects by transforming growth factor beta 1 by JUDE, E. B, BOULTON, A. J. M, FERGUSON, M. W. J, APPLETON, I

    Published in Diabetologia (01-06-1999)
    “…L-arginine, an amino acid involved in wound healing, is metabolised by one of two pathways; nitric oxide synthase and arginase. If metabolised by nitric oxide…”
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    Journal Article
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    Damage to the vestibular inner ear causes long-term changes in neuronal nitric oxide synthase expression in the rat hippocampus by Zheng, Y, Horii, A, Appleton, I, Darlington, C.L, Smith, P.F

    Published in Neuroscience (01-01-2001)
    “…The vestibular inner ear detects head acceleration and initiates compensatory eye movement and postural reflexes that help keep the visual image of the world…”
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    Journal Article
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    Apoptosis, necrosis, and proliferation: possible implications in the etiology of keloids by Appleton, I, Brown, NJ, Willoughby, DA

    Published in The American journal of pathology (01-11-1996)
    “…Keloids are collagenous lesions acquired as a result of abnormal wound heating. In this study we have assessed the potential role of proliferation, apoptosis,…”
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    Journal Article Conference Proceeding
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    Involvement of tyrosine kinase in the induction of cyclo‐oxygenase and nitric oxide synthase by endotoxin in cultured cells by Akarasereenont, P., Mitchell, J.A., Appleton, I., Thiemermann, C., Vane, J.R.

    Published in British journal of pharmacology (01-12-1994)
    “…1 Cyclo‐oxygenase (COX) and nitric oxide synthase (NOS) are two enzymes which have distinct cytokine‐inducible isoforms (COX‐2 and iNOS). Many cytokine…”
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    Journal Article
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    The role of antioxidants in models of inflammation: emphasis on L-arginine and arachidonic acid metabolism by Kapoor, M, Clarkson, A N, Sutherland, B A, Appleton, I

    Published in Inflammopharmacology (2005)
    “…Inflammatory processes are made up of a multitude of complex cascades. Under physiological conditions these processes aid in tissue repair. However, under…”
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    Journal Article
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    The pharmacological modulation of angiogenesis in chronic granulomatous inflammation by Colville-Nash, P R, Alam, C A, Appleton, I, Brown, J R, Seed, M P, Willoughby, D A

    “…Angiogenesis is required for the progression of chronic inflammation, and agents that alter it can affect the development of inflammation and the consequent…”
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    Journal Article
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    Wound Repair: The Role of Cytokines and Vasoactive Mediators by Appleton, I

    Published in Journal of the Royal Society of Medicine (01-09-1994)
    “…Editorial. [(BNI unique abstract)] 21 references…”
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    Journal Article
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    Temporal and spatial immunolocalization of cytokines in murine chronic granulomatous tissue. Implications for their role in tissue development and repair processes by Appleton, I, Tomlinson, A, Colville-Nash, P R, Willoughby, D A

    Published in Laboratory investigation (01-10-1993)
    “…Cytokines have profound effects on various aspects of granulomatous tissue formation. However, there is little information regarding their distribution during…”
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    Journal Article
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    Mechanisms of action of green tea catechins, with a focus on ischemia-induced neurodegeneration by Sutherland, Brad A., Rahman, Rosanna M.A., Appleton, Ian

    Published in The Journal of nutritional biochemistry (01-05-2006)
    “…Catechins are dietary polyphenolic compounds associated with a wide variety of beneficial health effects in vitro, in vivo and clinically. These therapeutic…”
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    Journal Article
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    Effect of endothelin-1 on croton oil-induced granulation tissue in the rat. A pharmacologic and immunohistochemical study by Appleton, I, Tomlinson, A, Chander, C L, Willoughby, D A

    Published in Laboratory investigation (01-12-1992)
    “…To date no attempts have been made to determine the role of the endothelial cell derived product, endothelin-1 (ET-1) in granulation tissue development. This…”
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    Journal Article
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