Search Results - "Applequist, Steven E"

Inhibition of intracellular antiviral defense mechanisms augments lentiviral transduction of human natural killer cells: implications for gene therapy by Sutlu, Tolga, Nyström, Sanna, Gilljam, Mari, Stellan, Birgitta, Applequist, Steven E, Alici, Evren

“…Adoptive immunotherapy with genetically modified natural killer (NK) cells is a promising approach for cancer treatment. Yet, optimization of highly efficient…”
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TLR activation regulates damage-associated molecular pattern isoforms released during pyroptosis by Nyström, Sanna, Antoine, Daniel J, Lundbäck, Peter, Lock, John G, Nita, Andreia F, Högstrand, Kari, Grandien, Alf, Erlandsson-Harris, Helena, Andersson, Ulf, Applequist, Steven E

“…Infection of macrophages by bacterial pathogens can trigger Toll‐like receptor (TLR) activation as well as Nod‐like receptors (NLRs) leading to inflammasome…”
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Long-Lasting Mucosal and Systemic Immunity against Influenza A Virus Is Significantly Prolonged and Protective by Nasal Whole Influenza Immunization with Mucosal Adjuvant N3 and DNA-Plasmid Expressing Flagellin in Aging In- and Outbred Mice by Hinkula, Jorma, Nyström, Sanna, Devito, Claudia, Bråve, Andreas, Applequist, Steven E

“…: Vaccination is commonly used to prevent and control influenza infection in humans. However, improvements in the ease of delivery and strength of…”
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Variable expression of Toll‐like receptor in murine innate and adaptive immune cell lines by Applequist, Steven E., Wallin, Robert P. A., Ljunggren, Hans‐Gustaf

“…Pattern recognition receptors (PRR) play an important roll in immediate responses to different conserved molecules produced by microbes. In this paper we…”
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In vivo engineering of mobilized stem cell grafts with the immunomodulatory drug FTY720 for allogeneic transplantation by Lakshmikanth, Tadepally, Heuts, Frank, Muvva, S. S. V. Jagadeeswara Rao, Wallin, Robert P. A., Persson, Anna‐Karin, Fauriat, Cyril, Applequist, Steven E., Ljunggren, Hans‐Gustaf, Höglund, Petter, Kärre, Klas, Svensson, Mattias, Juarez, Julius G.

“…The immunological attributes of stem cell grafts play an important role in the outcome of allogeneic stem cell transplants. Currently, ex vivo manipulation…”
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The adjuvant activity of alphavirus replicons is enhanced by incorporating the microbial molecule flagellin into the replicon by Knudsen, Maria L, Johansson, Daniel X, Kostic, Linda, Nordström, Eva K L, Tegerstedt, Karin, Pasetto, Anna, Applequist, Steven E, Ljungberg, Karl, Sirard, Jean-Claude, Liljeström, Peter

“…Ligands of pattern recognition receptors (PRRs) including Toll-like receptors (TLRs) stimulate innate and adaptive immune responses and are considered as…”
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DNA-Encoded Flagellin Activates Toll-Like Receptor 5 (TLR5), Nod-like Receptor Family CARD Domain-Containing Protein 4 (NRLC4), and Acts as an Epidermal, Systemic, and Mucosal-Adjuvant by Nyström, Sanna, Bråve, Andreas, Falkeborn, Tina, Devito, Claudia, Rissiek, Björn, Johansson, Daniel X, Schröder, Ulf, Uematsu, Satoshi, Akira, Shizuo, Hinkula, Jorma, Applequist, Steven E

“…Eliciting effective immune responses using non-living/replicating DNA vaccines is a significant challenge. We have previously shown that ballistic dermal…”
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Plasmid DNA vaccination using skin electroporation promotes poly-functional CD4 T-cell responses by Bråve, Andreas, Nyström, Sanna, Roos, Anna‐Karin, Applequist, Steven E

“…Plasmid DNA vaccination using skin electroporation (EP) is a promising method able to elicit robust humoral and CD8+ T‐cell immune responses while limiting…”
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Activation of Innate Immunity, Inflammation, and Potentiation of DNA Vaccination through Mammalian Expression of the TLR5 Agonist Flagellin by Applequist, Steven E, Rollman, Erik, Wareing, Mark D, Liden, Martin, Rozell, Bjorn, Hinkula, Jorma, Ljunggren, Hans-Gustaf

“…Improving DNA vaccination remains a fundamental goal in vaccine research. Theoretically, this could be achieved by molecules encoded by DNA capable of…”
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Boosting of HIV-1 neutralizing antibody responses by a distally related retroviral envelope protein by Uchtenhagen, Hannes, Schiffner, Torben, Bowles, Emma, Heyndrickx, Leo, LaBranche, Celia, Applequist, Steven E, Jansson, Marianne, De Silva, Thushan, Back, Jaap Willem, Achour, Adnane, Scarlatti, Gabriella, Fomsgaard, Anders, Montefiori, David, Stewart-Jones, Guillaume, Spetz, Anna-Lena

“…Our knowledge of the binding sites for neutralizing Abs (NAb) that recognize a broad range of HIV-1 strains (bNAb) has substantially increased in recent years…”
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TLR activation regulates damage-associated molecular pattern isoforms released during pyroptosis by Nyström, Sanna, Antoine, Daniel J, Lundbäck, Peter, Lock, John G, Nita, Andreia F, Högstrand, Kari, Grandien, Alf, Erlandsson-Harris, Helena, Andersson, Ulf, Applequist, Steven E

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Immunization with multiple vaccine modalities induce strong HIV-specific cellular and humoral immune responses by Hallengärd, David, Applequist, Steven E, Nyström, Sanna, Maltais, Anna-Karin, Marovich, Mary, Moss, Bernard, Earl, Patricia, Nihlmark, Kopek, Wahren, Britta, Bråve, Andreas

“…Heterologous priming and boosting with antigens expressed by DNA, viral vectors, or as proteins, are experimental strategies to induce strong immune responses…”
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Tripeptidyl-peptidase II controls DNA damage responses and In vivo γ-irradiation resistance of tumors by XU HONG, LU LEI, KUNERT, Brita, NAREDLA, Rajender, APPLEQUIST, Steven E, GRANDIEN, Alf, GLAS, Rickard

“…Cellular responses to gamma-irradiation exposure are controlled by phosphatidylinositol 3-kinase-related kinases (PIKK) in the nucleus, and in addition,…”
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Dissection of the Interaction of the Human Cytomegalovirus-derived US2 Protein with Major Histocompatibility Complex Class I Molecules: PROMINENT ROLE OF A SINGLE ARGININE RESIDUE IN HUMAN LEUKOCYTE ANTIGEN-A2 by Thilo, Claudia, Berglund, Peter, Applequist, Steven E, Yewdell, Jonathan W, Ljunggren, Hans-Gustaf, Achour, Adnane

“…Human cytomegalovirus encodes several proteins that interfere with expression of major histocompatibility complex (MHC) class I molecules on the surface of…”
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Antibody Production in Mice Deficient for Complement Receptors 1 and 2 Can Be Induced by IgG/Ag and IgE/Ag, But Not IgM/Ag Complexes by Applequist, Steven E, Dahlstrom, Jorgen, Jiang, Ning, Molina, Hector, Heyman, Birgitta

“…Deficiencies in C factors C2, C3, or C4 as well as lack of C receptors 1 and 2 (CR1/2) lead to impaired Ab production. Classical pathway activation plays a…”
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Dissection of the Interaction of the Human Cytomegalovirus-derived US2 Protein with Major Histocompatibility Complex Class I Molecules by Thilo, Claudia, Berglund, Peter, Applequist, Steven E., Yewdell, Jonathan W., Ljunggren, Hans-Gustaf, Achour, Adnane

“…Human cytomegalovirus encodes several proteins that interfere with expression of major histocompatibility complex (MHC) class I molecules on the surface of…”
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Erratum To: TLR activation regulates damage‐associated molecular pattern isoforms released during pyroptosis by Nyström, Sanna, Antoine, Daniel J, Lundbäck, Peter, Lock, John G, Nita, Andreia F, Högstrand, Kari, Grandien, Alf, Erlandsson‐Harris, Helena, Andersson, Ulf, Applequist, Steven E

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The Adjuvant Activity of Alphavirus Replicons Is Enhanced by Incorporating the Microbial Molecule Flagellin into the Replicon. e65964 by Knudsen, Maria L, Johansson, Daniel X, Kostic, Linda, Nordstrom, Eva KL, Tegerstedt, Karin, Pasetto, Anna, Applequist, Steven E, Ljungberg, Karl, Sirard, Jean-Claude, Liljestrom, Peter

“…Ligands of pattern recognition receptors (PRRs) including Toll-like receptors (TLRs) stimulate innate and adaptive immune responses and are considered as…”
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Cloning and characterization of HUPF1, a human homolog of the Saccharomyces cerevisiae nonsense mRNA-reducing UPF1 protein by Applequist, Steven E., Selg, Manuel, Raman, Chander, Jäck, Hans-Martin

“…Levels of most nonsense mRNAs are normally reduced in prokaryotes and eukaryotes when compared with that of corresponding functional mRNAs. Genes encoding…”
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Surrogate light chain-dependent selection of Ig heavy chain V regions by Keyna, U, Beck-Engeser, GB, Jongstra, J, Applequist, SE, Jack, HM

“…Bone marrow B cell precursors frequently rearrange the Ig heavy chain variable (VH) gene segment VH81X. It is puzzling, therefore, that mature B cells in adult…”
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