Search Results - "Appelt, Ane L"

High-dose chemoradiotherapy and watchful waiting for distal rectal cancer: a prospective observational study by Appelt, Ane L, Dr, Pløen, John, MD, Harling, Henrik, DMSc, Jensen, Frank S, PhD, Jensen, Lars H, PhD, Jørgensen, Jens C R, MD, Lindebjerg, Jan, MD, Rafaelsen, Søren R, DMSc, Jakobsen, Anders, Prof

“…Summary Background Abdominoperineal resection is the standard treatment for patients with distal T2 or T3 rectal cancers; however, the procedure is extensive…”
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Radiation Dose-Response Model for Locally Advanced Rectal Cancer After Preoperative Chemoradiation Therapy by Appelt, Ane L., MSc, Pløen, John, MD, Vogelius, Ivan R., PhD, Bentzen, Søren M., PhD, DSc, Jakobsen, Anders, DMSc

“…Purpose Preoperative chemoradiation therapy (CRT) is part of the standard treatment of locally advanced rectal cancers. Tumor regression at the time of…”
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Cell‐free DNA in healthy individuals, noncancerous disease and strong prognostic value in colorectal cancer by Spindler, Karen‐Lise Garm, Appelt, Ane L., Pallisgaard, Niels, Andersen, Rikke F., Brandslund, Ivan, Jakobsen, Anders

“…The purpose was to investigate total cell‐free DNA (cfDNA) in colorectal cancer (CRC) patients during treatment with second‐line chemotherapy and in healthy…”
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Prognostic factors for patients with anal cancer treated with conformal radiotherapy-a systematic review by Theophanous, Stelios, Samuel, Robert, Lilley, John, Henry, Ann, Sebag-Montefiore, David, Gilbert, Alexandra, Appelt, Ane L

“…Anal cancer is primarily treated using concurrent chemoradiotherapy (CRT), with conformal techniques such as intensity modulated radiotherapy (IMRT) and…”
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Phase 2 Neoadjuvant Treatment Intensification Trials in Rectal Cancer: A Systematic Review by Teo, Mark T.W., McParland, Lucy, Appelt, Ane L., Sebag-Montefiore, David

“…Multiple phase 2 trials of neoadjuvant treatment intensification in locally advanced rectal cancer have reported promising efficacy signals, but these have not…”
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Long-Term Results of a Randomized Trial in Locally Advanced Rectal Cancer: No Benefit From Adding a Brachytherapy Boost by Appelt, Ane L., PhD, Vogelius, Ivan R., PhD, Pløen, John, MD, Rafaelsen, Søren R., MD, Lindebjerg, Jan, MD, Havelund, Birgitte M., MD, PhD, Bentzen, Søren M., PhD, DSc, Jakobsen, Anders, DMSc

“…Purpose/Objective(s) Mature data on tumor control and survival are presented from a randomized trial of the addition of a brachytherapy boost to long-course…”
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A Phase II trial of Higher RadiOtherapy Dose In The Eradication of early rectal cancer (APHRODITE): protocol for a multicentre, open-label randomised controlled trial by Hudson, Eleanor M, Noutch, Samantha, Brown, Sarah, Adapala, Ravi, Bach, Simon P, Burnett, Carole, Burrage, Alwyn, Gilbert, Alexandra, Hawkins, Maria, Howard, Debra, Jefford, Monica, Kochhar, Rohit, Saunders, Mark, Seligmann, Jenny, Smith, Alexandra, Teo, Mark, Webb, Edward JD, Webster, Amanda, West, Nicholas, Sebag-Montefiore, David, Gollins, Simon, Appelt, Ane L

“…IntroductionThe standard of care for patients with localised rectal cancer is radical surgery, often combined with preoperative neoadjuvant…”
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GEC ESTRO ACROP consensus recommendations for contact brachytherapy for rectal cancer by Stewart, Alexandra J., Van Limbergen, Evert J., Gerard, Jean-Pierre, Appelt, Ane L., Verhaegen, Frank, Berbee, Maaike, Vuong, Te, Brooker, Ciarna, Rockall, Tim, Sun Myint, Arthur

“…•CXB appears to be an efficacious technique for rectal cancer treatment and may allow rectal preservation in selected patients.•These GEC ESTRO ACROP…”
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Individual lymph node position variation for rectal cancer patients treated with long course chemoradiotherapy by Arp, Dennis Tideman, Appelt, Ane L., Brøndum, Rasmus Froberg, Mikalone, Rasa, Nielsen, Martin Skovmos, Poulsen, Laurids Østergaard

“…•Systematic and random errors can be estimated using linear mixed modeling.•Systematic and random variations for lymph nodes increase when using tumor…”
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Reirradiation − still navigating uncharted waters? by Andratschke, Nicolaus, Willmann, Jonas, Appelt, Ane L, Day, Madalyne, Kronborg, Camilla, Massaccesi, Mariangela, Ozsahin, Mahmut, Pasquier, David, Petric, Primoz, Riesterer, Oliver, De Ruysscher, Dirk, M Van der Velden, Joanne, Guckenberger, Matthias

“…•Lack of high-quality evidence and standardized reporting for reirradiation studies.•Scarcity of preclinical data on reirradiation efficacy and tissue toxicity…”
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Early radiologic and metabolic tumour response assessment during combined chemo-radiotherapy for locally advanced NSCLC by Tvilum, Marie, Knap, Marianne Marquard, Hoffmann, Lone, Khalil, Azza Ahmed, Appelt, Ane L., Haraldsen, Ate, Alber, Markus, Grau, Cai, Schmidt, Hjørdis Hjalting, Kandi, Maria, Holt, Marianne Ingerslev, Lutz, Christina Maria, Møller, Ditte Sloth

“…•High baseline SUVpeak increases risk of loco-regional failure.•Poor response increases risk of distant metastasis for patients with squamous cell…”
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Improved heart, lung and target dose with deep inspiration breath hold in a large clinical series of breast cancer patients by Nissen, Henrik D, Appelt, Ane L

“…Abstract Background and purpose This study aims at evaluating the effect of deep-inspiration breath hold (DIBH) on target coverage and dose to organs at risk…”
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Mesorectal radiotherapy for early stage rectal cancer: A novel target volume by Peters, Femke P., Teo, Mark T.W., Appelt, Ane L., Bach, Simon, Baatrup, Gunnar, de Wilt, Johannes H.W., Jensenius Kronborg, Camilla, Garm Spindler, Karen-Lise, Marijnen, Corrie A.M., Sebag-Montefiore, David

“…With the introduction of population-based bowel cancer screening, rectal cancer is diagnosed at earlier stages, yet standard treatment still requires the same…”
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Robust dose planning objectives for mesorectal radiotherapy of early stage rectal cancer – A multicentre dose planning study by Appelt, Ane L., Kerkhof, Ellen M., Nyvang, Lars, Harderwijk, Ernst C., Abbott, Natalie L., Teo, Mark, Peters, Femke P., Kronborg, Camilla J.S., Spindler, Karen-Lise G., Sebag-Montefiore, David, Marijnen, Corrie A.M.

“…•Mesorectal-only RT for early rectal cancer requires dedicated planning guidelines.•A multi-centre study was conducted to identify planning objectives.•Robust…”
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European Society for Radiotherapy and Oncology and European Organisation for Research and Treatment of Cancer consensus on re-irradiation: definition, reporting, and clinical decision making by Andratschke, Nicolaus, Willmann, Jonas, Appelt, Ane L, Alyamani, Najlaa, Balermpas, Panagiotis, Baumert, Brigitta G, Hurkmans, Coen, Høyer, Morten, Langendijk, Johannes A, Kaidar-Person, Orit, van der Linden, Yvette, Meattini, Icro, Niyazi, Maximilian, Reynaert, Nick, De Ruysscher, Dirk, Tanadini-Lang, Stephanie, Hoskin, Peter, Poortmans, Philip, Nieder, Carsten

“…Re-irradiation can be considered for local recurrence or new tumours adjacent to a previously irradiated site to achieve durable local control for patients…”
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Prognostic Value of Serum NPY Hypermethylation in Neoadjuvant Chemoradiotherapy for Rectal Cancer: Secondary Analysis of a Randomized Trial by Appelt, Ane L., Andersen, Rikke F., Lindebjerg, Jan, Jakobsen, Anders

“…Long-term prevention of metastatic disease remains a challenge in locally advanced rectal cancer, and robust pretreatment prognostic factors for metastatic…”
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Dose summation and image registration strategies for radiobiologically and anatomically corrected dose accumulation in pelvic re-irradiation by Nix, Mike, Gregory, Stephen, Aldred, Michael, Aspin, Lynn, Lilley, John, Al-Qaisieh, Bashar, Uzan, Julien, Svensson, Stina, Dickinson, Peter, Appelt, Ane L, Murray, Louise

“…Re-irradiation (reRT) is a promising technique for patients with localized recurrence in a previously irradiated area but presents major challenges. These…”
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Technological advances in radiotherapy of rectal cancer: opportunities and challenges by Appelt, Ane L, Sebag-Montefiore, David

“…PURPOSE OF REVIEWThis review summarizes the available evidence for the use of modern radiotherapy techniques for chemoradiotherapy for rectal cancer, with…”
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Dose-Response and Normal Tissue Complication Probabilities after Proton Therapy for Choroidal Melanoma by Espensen, Charlotte A., Kiilgaard, Jens F., Appelt, Ane L., Fog, Lotte S., Herault, Joel, Maschi, Celia, Caujolle, Jean-Pierre, Thariat, Juliette

“…Normal tissue complication probability (NTCP) models could aid the understanding of dose dependence of radiation-induced toxicities after eye-preserving…”
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Efficacy of Dose-Escalated Chemoradiation on Complete Tumor Response in Patients with Locally Advanced Rectal Cancer (RECTAL-BOOST): A Phase 2 Randomized Controlled Trial by Couwenberg, Alice M., Burbach, Johannes P.M., Berbee, Maaike, Lacle, Miangela M., Arensman, René, Raicu, Mihaela G., Wessels, Frank J., Verdult, Joanne, Roodhart, Jeanine, Reerink, Onne, Hoendervangers, Sieske, Buijsen, Jeroen, Grabsch, Heike I., Pronk, Apollo, Consten, Esther C.J., Smits, Anke B., Heikens, Joost T., Appelt, Ane L., van Grevenstein, Wilhelmina M.U., Verkooijen, Helena M., Intven, Martijn P.W.

“…Pathologic complete tumor response after chemoradiation in patients with locally advanced rectal cancer (LARC) is associated with a favorable prognosis and…”
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