Search Results - "Appell, K"

Chronic hemodialysis using venipuncture and a surgically created arteriovenous fistula. 1966 by Brescia, M J, Cimino, J E, Appell, K, Hurwich, B J, Scribner, B H

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Antagonists that demonstrate species differences in neurokinin-1 receptors by Appell, K C, Fragale, B J, Loscig, J, Singh, S, Tomczuk, B E

“…125I-Bolton-Hunter-substance P (125I-BH-SP) binding properties of three novel classes of neurokinin-1 (NK-1) receptor antagonists were investigated in tissues…”
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Ultra-high throughput screen of two-million-member combinatorial compound collection in a miniaturized, 1536-well assay format by Dunn, D, Orlowski, M, McCoy, P, Gastgeb, F, Appell, K, Ozgur, L, Webb, M, Burbaum, J

“…Results of a complete survey of the more than 2-million-member Pharmacopeia compound collection in a 1536-well microvolume screening assay format are reported…”
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Neurotransmitter release from bradykinin-stimulated PC12 cells. Stimulation of cytosolic calcium and neurotransmitter release by Appell, K C, Barefoot, D S

“…The effect of bradykinin on intracellular free Ca2+ and neurotransmitter secretion was investigated in the rat pheochromocytoma cell line PC12. Bradykinin was…”
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Characterization of the reversible conformational equilibrium of the cytoplasmic domain of erythrocyte membrane band 3 by Low, P S, Westfall, M A, Allen, D P, Appell, K C

“…The cytoplasmic domain of the erythrocyte membrane protein, band 3, contains binding sites for hemoglobin, several glycolytic enzymes, and ankyrin, the linkage…”
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Chemokine Receptor−Ligand Interactions Measured Using Time-Resolved Fluorescence by Inglese, James, Samama, Philippe, Patel, Sanjay, Burbaum, Jonathan, Stroke, Ilana L, Appell, Kenneth C

“…Two G protein-coupled receptor subtypes (CXCR1 and CXCR2) mediate Interleukin-8 (IL8) action in cells. A nonradioactive lanthanide−chelate derivatized IL8…”
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Synthesis and substance P receptor binding activity of androstano[3,2-b]pyrimido[1,2-a]benzimidazoles by Venepalli, Bhaskar R, Aimone, Lisa D, Appell, Kenneth C, Bell, Malcolm R, Dority, John A, Goswami, Ramanuj, Hall, Patricia L, Kumar, Virendra, Lawrence, Kristine B

“…Several heterosteroids containing a dihydroethisterone skeleton were prepared and shown to displace substance P in a receptor binding assay. Further…”
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A novel high-throughput screening format to identify inhibitors of secreted acid sphingomyelinase by Mintzer, Robert J, Appell, Kenneth C, Cole, Andrew, Johns, Anthony, Pagila, Rene, Polokoff, Mark A, Tabas, Ira, Snider, R Michael, Meurer-Ogden, Janet A

“…Secreted extracellular acid sphingomyelinase (sASM) activity has been suggested to promote atherosclerosis by enhancing subendothelial aggregation and…”
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Characterization of the stimulatory action of insulin on insulin-like growth factor II binding to rat adipose cells. Differences in the mechanism of insulin action on insulin-like growth factor II receptors and glucose transporters by Appell, K C, Simpson, I A, Cushman, S W

“…Insulin is known to increase the number of cell surface insulin-like growth factor II (IGF-II) receptors in isolated rat adipose cells through a subcellular…”
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Partial structural characterization of the cytoplasmic domain of the erythrocyte membrane protein, band 3 by Appell, K C, Low, P S

“…The cytoplasmic domain of band 3 was released from spectrin-depleted, acetic acid-stripped erythrocyte membrane vesicles by mild chymotryptic digestion. After…”
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Identification of immunoreactive forms of human erythrocyte band 3 in nonerythroid cells by Drenckhahn, D, Zinke, K, Schauer, U, Appell, K C, Low, P S

“…Antibodies directed to the cytoplasmic domain of human erythrocyte band 3, the major integral protein of the erythrocyte membrane which is thought to be the…”
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Insulin-induced subcellular redistribution of insulin-like growth factor II receptors in the rat adipose cell. Counterregulatory effects of isoproterenol, adenosine, and cAMP analogues by Lönnroth, P, Appell, K C, Wesslau, C, Cushman, S W, Simpson, I A, Smith, U

“…Insulin shifts the steady-state subcellular distribution of insulin-like growth factor II (IGF-II) receptors from a large intracellular pool to the plasma…”
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Synthesis and substance P antagonist activity of naphthimidazolium derivatives by Lawrence, Kristine B, Venepalli, Bhaskar R, Appell, Kenneth C, Goswami, Ramanuj, Logan, Margaret E, Tomczuk, Bruce E, Yanni, John M

“…The synthesis of unsymmetrical naphth[2,3-d]imidazolium and bridged naphth[2,3-d]imidazolium derivatives and their substance P (SP) antagonist activity are…”
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Imidazo[4,5-b]quinoxaline cyanines as neurokinin antagonists by Appell, Kenneth C, Babb, Bruce E, Goswami, Ramanuj, Hall, Patricia L, Lawrence Kristine B, Logan, Margaret E, Przyklek-Elling, Rose, Tomczuk, Bruce E, Venepalli, Bhaskar R, Yanni, John M

“…Substance P (SP) is an undecapeptide neuromodulator that belongs to the neurokinin (NK) family, which includes the structurally related neurokinin A (NKA) and…”
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AHR-16303B, a novel antagonist of 5-HT2 receptors and voltage-sensitive calcium channels by Barrett, R J, Appell, K C, Kilpatrick, B F, Proakis, A G, Nolan, J C, Walsh, D A

“…In vivo and in vitro methods were used to characterize AHR-16303B, a novel compound with antagonistic action at 5-HT2 receptors and voltage-sensitive calcium…”
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WIN 64821, a novel neurokinin antagonist produced by an Aspergillus sp. II. Biological activity by Oleynek, J J, Sedlock, D M, Barrow, C J, Appell, K C, Casiano, F, Haycock, D, Ward, S J, Kaplita, P, Gillum, A M

“…WIN 64821, a secondary metabolite produced by Aspergillus sp. (ATCC 74177) was found to inhibit radiolabeled substance P (SP) binding in a variety of tissues,…”
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Preparation and characterization of monoclonal antibodies to substance P by Frickey, P H, Yanni, J M, Appell, K

“…A series of mouse hybridomas that produced monoclonal antibodies reactive with Substance P was prepared in an attempt to find a surrogate NK-1 receptor. When…”
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Serum creatine kinase activity and its changes after a muscle biopsy by Hikida, R S, Staron, R S, Hagerman, F C, Leonardi, M, Gilders, R, Falkel, J, Murray, T, Appell, K

“…The significance of the absolute elevations of serum creatine kinase (CK) levels after intense exercise and injuries was studied by measuring CK activities…”
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Evaluation of the structural interdependence of the membrane-spanning and cytoplasmic domains of band 3 by Appell, Kenneth C, Low, Philip S

“…The structural interdependence of the membrane-spanning (55,000 dalton) and cytoplasmic (40,000 dalton) domains of the erythrocyte membrane protein band 3 was…”
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Anthrotainin, an inhibitor of substance P binding produced by Gliocladium catenulatum by Wong, S M, Kullnig, R, Dedinas, J, Appell, K C, Kydd, G C, Gillum, A M, Cooper, R, Moore, R

“…Substance P (SP) is an undecapeptide belonging to a family of chemically related neurotransmitters and neuromodulators known as neurokinins. In our search for…”
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