Search Results - "Appel, Stanley"

Immune dysregulation in amyotrophic lateral sclerosis: mechanisms and emerging therapies by Beers, David R, Appel, Stanley H

“…Neuroinflammation is a common pathological feature of many neurodegenerative diseases, including amyotrophic lateral sclerosis (ALS), and is characterised by…”
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Immune-mediated Mechanisms in the Pathoprogression of Amyotrophic Lateral Sclerosis by Zhao, Weihua, Beers, David R., Appel, Stanley H.

“…Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disease with selective loss of upper and lower motor neurons. At sites of motor neuron…”
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Neuroinflammatory mechanisms in amyotrophic lateral sclerosis pathogenesis by Thonhoff, Jason R, Simpson, Ericka P, Appel, Stanley H

“…Neuroinflammation is increasingly recognized as an important mediator of disease progression in patients with amyotrophic lateral sclerosis (ALS), and is…”
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Amyotrophic lateral sclerosis is a systemic disease: peripheral contributions to inflammation-mediated neurodegeneration by Appel, Stanley H., Beers, David R., Zhao, Weihua

“…Neuroinflammation is an important mediator of the pathogenesis of disease in amyotrophic lateral sclerosis (ALS). Genetic mutations such as C9orf72 have begun…”
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Protective and Toxic Neuroinflammation in Amyotrophic Lateral Sclerosis by Hooten, Kristopher G., Beers, David R., Zhao, Weihua, Appel, Stanley H.

“…Amyotrophic lateral sclerosis (ALS) is a clinically heterogeneous disorder characterized by loss of motor neurons, resulting in paralysis and death. Multiple…”
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Transformation from a neuroprotective to a neurotoxic microglial phenotype in a mouse model of ALS by Liao, Bing, Zhao, Weihua, Beers, David R., Henkel, Jenny S., Appel, Stanley H.

“…Neuroinflammation is a prominent pathological feature in the spinal cords of patients with amyotrophic lateral sclerosis (ALS), as well as in transgenic mouse…”
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TDP-43 activates microglia through NF-κB and NLRP3 inflammasome by Zhao, Weihua, Beers, David R., Bell, Shaughn, Wang, Jinghong, Wen, Shixiang, Baloh, Robert H., Appel, Stanley H.

“…Transactive response DNA-binding protein-43 (TDP-43) is a multifunctional nucleic acid binding protein present in ubiquitinated inclusions in tissues of…”
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An antisense oligonucleotide against SOD1 delivered intrathecally for patients with SOD1 familial amyotrophic lateral sclerosis: a phase 1, randomised, first-in-man study by Miller, Timothy M, Dr, Pestronk, Alan, Prof, David, William, MD, Rothstein, Jeffrey, Prof, Simpson, Ericka, MD, Appel, Stanley H, Prof, Andres, Patricia L, MS, Mahoney, Katy, BA, Allred, Peggy, DPT, Alexander, Katie, BA, Ostrow, Lyle W, MD, Schoenfeld, David, Prof, Macklin, Eric A, PhD, Norris, Daniel A, PhD, Manousakis, Georgios, MD, Crisp, Matthew, BS, Smith, Richard, MD, Bennett, C Frank, PhD, Bishop, Kathie M, PhD, Cudkowicz, Merit E, Prof

“…Summary Background Mutations in SOD1 cause 13% of familial amyotrophic lateral sclerosis. In the SOD1 Gly93Ala rat model of amyotrophic lateral sclerosis, the…”
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CD4+ T cells mediate cytotoxicity in neurodegenerative diseases by Appel, Stanley H

“…Neuroinflammation, characterized by activated microglia and infiltrating T cells, is a prominent pathological feature in neurodegenerative diseases. However,…”
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Serum C-Reactive Protein as a Prognostic Biomarker in Amyotrophic Lateral Sclerosis by Lunetta, Christian, Lizio, Andrea, Maestri, Eleonora, Sansone, Valeria Ada, Mora, Gabriele, Miller, Robert G, Appel, Stanley H, Chiò, Adriano

“…Various factors have been proposed as possible candidates associated with the prognosis of amyotrophic lateral sclerosis (ALS); however, there is still no…”
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Increased activation ability of monocytes from ALS patients by Du, Yunlan, Zhao, Weihua, Thonhoff, Jason R., Wang, Jinghong, Wen, Shixiang, Appel, Stanley H.

“…Neuroinflammation is increasingly recognized as an important mediator of disease progression in patients with amyotrophic lateral sclerosis (ALS). Recent…”
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Blood–spinal cord barrier breakdown and pericyte reductions in amyotrophic lateral sclerosis by Winkler, Ethan A., Sengillo, Jesse D., Sullivan, John S., Henkel, Jenny S., Appel, Stanley H., Zlokovic, Berislav V.

“…The blood–brain barrier and blood–spinal cord barrier (BSCB) limit the entry of plasma components and erythrocytes into the central nervous system (CNS)…”
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Genome-wide Analyses Identify KIF5A as a Novel ALS Gene by Kenna, Kevin P., Chia, Ruth, Dominov, Janice A., Nalls, Mike A., van Vugt, Joke J.F.A., Simone, Isabella, Caredda, Carla, Milia, Antonio, Floris, Gianluca, Caponnetto, Claudia, Mandich, Paola, Mora, Gabriele, Sideri, Riccardo, Penco, Silvana, Mandrioli, Jessica, Trojsi, Francesca, Ticca, Anna, Ortu, Enzo, Pugliatti, Maura, Benigni, Michele, Brunetti, Maura, Marrali, Giuseppe, Riva, Nilo, Conforti, Francesca L., Messina, Sonia, D’Alfonso, Sandra, Baloh, Robert H., Penny, Michelle, Moreno, Cristiane de Araujo Martins, Chung, Wendy K., Cirulli, Elizabeth T., Harris, Tim, Krueger, Brian J., Lasseigne, Brittany N., McKenna-Yasek, Diane, Myers, Richard M., Pulst, Stefan M., Raphael, Alya R., Rouleau, Guy A., Sapp, Peter C., Waite, Lindsay L., Wang, Quanli, Ostrow, Lyle W., Baas, Frank, Zaitlen, Noah, Hornstein, Eran, Patsopoulos, Nikolaos A., Kaye, Julia, Wyman, Stacia, LeNail, Alexander, Baxi, Emily, LeNail, Alex, Benatar, Michael, Hussain, Sumaira, Swenson, Andrea, Jackson, Carlayne, So, Yuen, Wuu, Joanne, Silani, Vincenzo, Fogh, Isabella, Cereda, Cristina, Ceroni, Mauro, Mazzini, Letizia, Maderna, Luca, Sorarù, Gianni, Bernard, Emilien, Laaksovirta, Hannu, McKenna-Yasek, Diane, Asress, Seneshaw, Al-Sarraj, Safa, Scholz, Sonja W., MacGowan, Daniel J.L., Kirby, Janine, Pioro, Erik P., Pamphlett, Roger, Dunckley, Travis L., Troncoso, Juan C., Moisse, Matthieu, Drory, Vivian E., Turner, Martin R., Blair, Ian P., de Carvalho, Mamede, Hide, Winston, Glass, Jonathan, Mill, Jonathan, Newhouse, Stephen, Pulit, Sara, Robberecht, Wim, Shaw, Pamela, van den Berg, Leonard, Williams, Kelly L., Zatz, Mayana, Rothstein, Jeffrey D., Simmons, Zachary, Van Damme, Philip, Sabatelli, Mario, Trojanowski, John Q., Brown, Robert H., Veldink, Jan H., Tienari, Pentti

“…To identify novel genes associated with ALS, we undertook two lines of investigation. We carried out a genome-wide association study comparing 20,806 ALS cases…”
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CD4+ T cells support glial neuroprotection, slow disease progression, and modify glial morphology in an animal model of inherited ALS by Beers, David R, Henkel, Jenny S, Zhao, Weihua, Wang, Jinghong, Appel, Stanley H

“…Neuroinflammation, marked by gliosis and infiltrating T cells, is a prominent pathological feature in diverse models of dominantly inherited neurodegenerative…”
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Characterization of Gene Expression Phenotype in Amyotrophic Lateral Sclerosis Monocytes by Zhao, Weihua, Beers, David R, Hooten, Kristopher G, Sieglaff, Douglas H, Zhang, Aijun, Kalyana-Sundaram, Shanker, Traini, Christopher M, Halsey, Wendy S, Hughes, Ashley M, Sathe, Ganesh M, Livi, George P, Fan, Guo-Huang, Appel, Stanley H

“…Amyotrophic lateral sclerosis (ALS) is a common adult-onset neurodegenerative disease characterized by selective loss of upper and lower motor neurons…”
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T cell-microglial dialogue in Parkinson's disease and amyotrophic lateral sclerosis: are we listening? by Appel, Stanley H, Beers, David R, Henkel, Jenny S

“…Neuroinflammation is a pathological hallmark in Parkinson's disease (PD) and amyotrophic lateral sclerosis (ALS), and is characterized by activated microglia…”
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Endogenous regulatory T lymphocytes ameliorate amyotrophic lateral sclerosis in mice and correlate with disease progression in patients with amyotrophic lateral sclerosis by BEERS, David R, HENKEL, Jenny S, WEIHUA ZHAO, JINGHONG WANG, AILING HUANG, SHIXIANG WEN, BING LIAO, APPEL, Stanley H

“…Amyotrophic lateral sclerosis is a relentless and devastating adult-onset neurodegenerative disease with no known cure. In mice with amyotrophic lateral…”
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Inflammation in Parkinson's disease: Cause or consequence? by Appel, Stanley H.

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Regulatory T‐lymphocytes mediate amyotrophic lateral sclerosis progression and survival by Henkel, Jenny S., Beers, David R., Wen, Shixiang, Rivera, Andreana L., Toennis, Karen M., Appel, Joan E., Zhao, Weihua, Moore, Dan H., Powell, Suzanne Z., Appel, Stanley H.

“…In amyotrophic lateral sclerosis (ALS) mice, regulatory T‐lymphocytes (Tregs) are neuroprotective, slowing disease progression. To address whether Tregs and…”
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TREM2 variant p.R47H as a risk factor for sporadic amyotrophic lateral sclerosis by Cady, Janet, Koval, Erica D, Benitez, Bruno A, Zaidman, Craig, Jockel-Balsarotti, Jennifer, Allred, Peggy, Baloh, Robert H, Ravits, John, Simpson, Ericka, Appel, Stanley H, Pestronk, Alan, Goate, Alison M, Miller, Timothy M, Cruchaga, Carlos, Harms, Matthew B

“…Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease in which microglia play a significant and active role. Recently, a rare missense…”
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