Search Results - "Appel, Klaus E."

Toxicology and risk assessment of 5-Hydroxymethylfurfural in food by Abraham, Klaus, Gürtler, Rainer, Berg, Katharina, Heinemeyer, Gerhard, Lampen, Alfonso, Appel, Klaus E.

“…5‐Hydroxymethylfurfural (5‐HMF) as a product of the Maillard reaction is found in many foods. Estimated intakes range between 4 and 30 mg per person and day,…”
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Relative oral bioavailability of 3-MCPD from 3-MCPD fatty acid esters in rats by Abraham, Klaus, Appel, Klaus E., Berger-Preiss, Edith, Apel, Elisabeth, Gerling, Susanne, Mielke, Hans, Creutzenberg, Otto, Lampen, Alfonso

“…In order to quantify the relative oral bioavailability of 3-chloropropane-1,2-diol (3-MCPD) from 3-MCPD fatty acid diesters in vivo,…”
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Toxicology and risk assessment of acrolein in food by Abraham, Klaus, Andres, Susanne, Palavinskas, Richard, Berg, Katharina, Appel, Klaus E., Lampen, Alfonso

“…Acrolein is an α,β‐unsaturated aldehyde formed by thermal treatment of animal and vegetable fats, carbohydrates and amino acids. In addition it is generated…”
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Abundance of DNA adducts of methyleugenol, a rodent hepatocarcinogen, in human liver samples by Herrmann, Kristin, Schumacher, Fabian, Engst, Wolfram, Appel, Klaus E, Klein, Kathrin, Zanger, Ulrich M, Glatt, Hansruedi

“…Methyleugenol is a genotoxic carcinogen in mice and rats, the liver being the primary target tissue. Methyleugenol occurs in fennel and many herbs and spices…”
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Relative oral bioavailability of glycidol from glycidyl fatty acid esters in rats by Appel, Klaus E., Abraham, Klaus, Berger-Preiss, Edith, Hansen, Tanja, Apel, Elisabeth, Schuchardt, Sven, Vogt, Carla, Bakhiya, Nadiya, Creutzenberg, Otto, Lampen, Alfonso

“…In order to quantify the relative bioavailability of glycidol from glycidyl fatty acid esters in vivo, glycidyl palmitoyl ester and glycidol were orally…”
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Uptake of permethrin from impregnated clothing by Rossbach, Bernd, Appel, Klaus E., Mross, Klaus G., Letzel, Stephan

“…In order to examine exposure and health risks which can arise from permethrin-impregnated clothing, a controlled trial was conducted. In a study group…”
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Human CYP2E1 mediates the formation of glycidamide from acrylamide by Settels, Eva, Bernauer, Ulrike, Palavinskas, Richard, Klaffke, Horst S, Gundert-Remy, Ursula, Appel, Klaus E

“…Regarding the cancer risk assessment of acrylamide (AA) it is of basic interest to know, as to what amount of the absorbed AA is metabolized to glycidamide…”
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Toxicology, occurrence and risk characterisation of the chloropropanols in food: 2-Monochloro-1,3-propanediol, 1,3-dichloro-2-propanol and 2,3-dichloro-1-propanol by Andres, Susanne, Appel, Klaus E., Lampen, Alfonso

“…•The chloropropanols 2-MCPD, 1,3-DCP and 2,3-DCP have been found in certain foods.•The exposure of the toxicological relevant 1,3-DCP is of low concern for…”
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Carcinogenic risks of dioxin: Mechanistic considerations by Schwarz, Michael, Appel, Klaus E.

“…Dioxins and dioxin-like chemicals demonstrate high affinity binding to the aryl hydrocarbon receptor (AhR), a ligand activated transcription factor, which…”
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Chronic oral LOAEL prediction by using a commercially available computational QSAR tool by Rupp, Bernd, Appel, Klaus E, Gundert-Remy, Ursula

“…In the absence of toxicological data, as it is the case for, e.g. naturally occurring substances and chemicals underlying the new European chemicals…”
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Toxicity and carcinogenicity of furan in human diet by Bakhiya, Nadiya, Appel, Klaus E

“…Furan is formed during commercial or domestic thermal treatment of food. The initial surveys of furan concentrations in heat-treated foods, published by…”
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Effects of peripubertal exposure to triphenyltin on female sexual development of the rat by Grote, Konstanze, Andrade, Anderson J.M., Grande, Simone Wichert, Kuriyama, Sergio N., Talsness, Chris E., Appel, Klaus E., Chahoud, Ibrahim

“…Triphenyltin (TPT) belongs to the group of organotin compounds which have been shown to affect reproduction in mammals. It is used as a fungicide and…”
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Comparative Transcriptome and Proteome Analysis of Ha-ras and B-raf Mutated Mouse Liver Tumors by Rignall, Benjamin, Ittrich, Carina, Krause, Eberhard, Appel, Klaus E., Buchmann, Albrecht, Schwarz, Michael

“…Mouse liver tumors frequently harbor activating mutations in the Ha-ras protooncogene. In addition, mutations are also found in the B-raf gene leading to…”
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Organotin Compounds: Toxicokinetic Aspects by Appel, Klaus E.

“…Organotin compounds have a broad range of applications. While dialkyltin compounds are used primarily as stabilizers for plastics, trisubstituted organotins…”
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Biological and tumor-promoting effects of dioxin-like and non-dioxin-like polychlorinated biphenyls in mouse liver after single or combined treatment by Rignall, Benjamin, Grote, Konstanze, Gavrilov, Alina, Weimer, Marc, Kopp-Schneider, Annette, Krause, Eberhard, Appel, Klaus E, Buchmann, Albrecht, Robertson, Larry W, Lehmler, Hans-Joachim, Kania-Korwel, Izabela, Chahoud, Ibrahim, Schwarz, Michael

“…To assess the impact of a mixture containing dioxin-like and non-dioxin-like polychlorinated biphenyls (PCBs), male mice were initiated with…”
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Identification of human and murine sulfotransferases able to activate hydroxylated metabolites of methyleugenol to mutagens in Salmonella typhimurium and detection of associated DNA adducts using UPLC-MS/MS methods by Herrmann, Kristin, Engst, Wolfram, Appel, Klaus E, Monien, Bernhard H, Glatt, Hansruedi

“…Methyleugenol, a secondary metabolite present in many herbal spices, is carcinogenic in various tissues of mice and rats but negative in standard in vitro…”
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Risk assessment of Bundeswehr (German Federal Armed Forces) permethrin-impregnated battle dress uniforms (BDU) by Appel, Klaus E., Gundert-Remy, Ursula, Fischer, Horst, Faulde, Michael, Mross, Klaus G., Letzel, Stephan, Rossbach, Bernd

“…In an age when vector-borne diseases are emerging worldwide, personal protective measures are essential for shielding soldiers and other exposed persons from…”
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Effects of organotin compounds on pubertal male rats by Grote, Konstanze, Stahlschmidt, Beate, Talsness, Chris E., Gericke, Christine, Appel, Klaus E., Chahoud, Ibrahim

“…Tributyltin (TBT) and triphenyltin (TPT) induce effects in male and female reproductive organs of rodents. They also cause tumors in these organs and it is…”
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PCB 153, a Non-dioxin–like Tumor Promoter, Selects for β-Catenin (Catnb)–Mutated Mouse Liver Tumors by Strathmann, Julia, Schwarz, Michael, Tharappel, Job C., Glauert, Howard P., Spear, Brett T., Robertson, Larry W., Appel, Klaus E., Buchmann, Albrecht

“…Polychlorinated biphenyls (PCBs) are ubiquitous environmental toxicants which act as liver tumor promoters in rodents and can be classified as either…”
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Sex-dependent aromatase activity in rat offspring after pre- and postnatal exposure to triphenyltin chloride by Hobler, Carolin, Andrade, Anderson J.M, Grande, Simone Wichert, Gericke, Christine, Talsness, Chris E, Appel, Klaus E, Chahoud, Ibrahim, Grote, Konstanze

“…Abstract Triphenyltin (TPT) is an organotin compound (OTC) previously widely used as an antifouling agent in paints applied in the marine environment, a…”
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