Search Results - "Appel, Emil"

Human pancreatic islet three-dimensional chromatin architecture provides insights into the genetics of type 2 diabetes by Miguel-Escalada, Irene, Bonàs-Guarch, Silvia, Cebola, Inês, Ponsa-Cobas, Joan, Mendieta-Esteban, Julen, Atla, Goutham, Javierre, Biola M., Rolando, Delphine M. Y., Farabella, Irene, Morgan, Claire C., García-Hurtado, Javier, Beucher, Anthony, Morán, Ignasi, Pasquali, Lorenzo, Ramos-Rodríguez, Mireia, Appel, Emil V. R., Linneberg, Allan, Gjesing, Anette P., Witte, Daniel R., Pedersen, Oluf, Grarup, Niels, Ravassard, Philippe, Torrents, David, Mercader, Josep M., Piemonti, Lorenzo, Berney, Thierry, de Koning, Eelco J. P., Kerr-Conte, Julie, Pattou, François, Fedko, Iryna O., Groop, Leif, Prokopenko, Inga, Hansen, Torben, Marti-Renom, Marc A., Fraser, Peter, Ferrer, Jorge

“…Genetic studies promise to provide insight into the molecular mechanisms underlying type 2 diabetes (T2D). Variants associated with T2D are often located in…”
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Obesity and Bariatric Surgery Drive Epigenetic Variation of Spermatozoa in Humans by Donkin, Ida, Versteyhe, Soetkin, Ingerslev, Lars R., Qian, Kui, Mechta, Mie, Nordkap, Loa, Mortensen, Brynjulf, Appel, Emil Vincent R., Jørgensen, Niels, Kristiansen, Viggo B., Hansen, Torben, Workman, Christopher T., Zierath, Juleen R., Barrès, Romain

“…Obesity is a heritable disorder, with children of obese fathers at higher risk of developing obesity. Environmental factors epigenetically influence somatic…”
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Cohort-wide deep whole genome sequencing and the allelic architecture of complex traits by Gilly, Arthur, Suveges, Daniel, Kuchenbaecker, Karoline, Pollard, Martin, Southam, Lorraine, Hatzikotoulas, Konstantinos, Farmaki, Aliki-Eleni, Bjornland, Thea, Waples, Ryan, Appel, Emil V. R., Casalone, Elisabetta, Melloni, Giorgio, Kilian, Britt, Rayner, Nigel W., Ntalla, Ioanna, Kundu, Kousik, Walter, Klaudia, Danesh, John, Butterworth, Adam, Barroso, Inês, Tsafantakis, Emmanouil, Dedoussis, George, Moltke, Ida, Zeggini, Eleftheria

“…The role of rare variants in complex traits remains uncharted. Here, we conduct deep whole genome sequencing of 1457 individuals from an isolated population,…”
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Estimating narrow-sense heritability using family data from admixed populations by Athanasiadis, Georgios, Speed, Doug, Andersen, Mette K, Appel, Emil V R, Grarup, Niels, Brandslund, Ivan, Jørgensen, Marit Eika, Larsen, Christina Viskum Lytken, Bjerregaard, Peter, Hansen, Torben, Albrechtsen, Anders

“…Estimating total narrow-sense heritability in admixed populations remains an open question. In this work, we used extensive simulations to evaluate existing…”
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A genome-wide association study of thyroid stimulating hormone and free thyroxine in Danish children and adolescents by Nielsen, Tenna Ruest Haarmark, Appel, Emil Vincent Rosenbaum, Svendstrup, Mathilde, Ohrt, Johanne Dam, Dahl, Maria, Fonvig, Cilius Esmann, Hollensted, Mette, Have, Christian Theil, Kadarmideen, Haja N, Pedersen, Oluf, Hansen, Torben, Holm, Jens-Christian, Grarup, Niels

“…Hypothyroidism is associated with obesity, and thyroid hormones are involved in the regulation of body composition, including fat mass. Genome-wide association…”
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Insulin resistance genetic risk score and burden of coronary artery disease in patients referred for coronary angiography by Skals, Regitze, Krogager, Maria Lukács, Appel, Emil Vincent R, Schnurr, Theresia M, Have, Christian Theil, Gislason, Gunnar, Poulsen, Henrik Enghusen, Køber, Lars, Engstrøm, Thomas, Stender, Steen, Hansen, Torben, Grarup, Niels, Lee, Christina Ji-Young, Andersson, Charlotte, Torp-Pedersen, Christian, Weeke, Peter E

“…Aims Insulin resistance associates with development of metabolic syndrome and risk of cardiovascular disease. The link between insulin resistance and…”
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Comparative Analyses of QTLs Influencing Obesity and Metabolic Phenotypes in Pigs and Humans by Pant, Sameer D, Karlskov-Mortensen, Peter, Jacobsen, Mette J, Cirera, Susanna, Kogelman, Lisette J A, Bruun, Camilla S, Mark, Thomas, Jørgensen, Claus B, Grarup, Niels, Appel, Emil V R, Galjatovic, Ehm A A, Hansen, Torben, Pedersen, Oluf, Guerin, Maryse, Huby, Thierry, Lesnik, Philipppe, Meuwissen, Theo H E, Kadarmideen, Haja N, Fredholm, Merete

“…The pig is a well-known animal model used to investigate genetic and mechanistic aspects of human disease biology. They are particularly useful in the context…”
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Re-analysis of public genetic data reveals a rare X-chromosomal variant associated with type 2 diabetes by Bonàs-Guarch, Sílvia, Guindo-Martínez, Marta, Miguel-Escalada, Irene, Grarup, Niels, Sebastian, David, Rodriguez-Fos, Elias, Sánchez, Friman, Planas-Fèlix, Mercè, Cortes-Sánchez, Paula, González, Santi, Timshel, Pascal, Pers, Tune H., Morgan, Claire C., Moran, Ignasi, Atla, Goutham, González, Juan R., Puiggros, Montserrat, Martí, Jonathan, Andersson, Ehm A., Díaz, Carlos, Badia, Rosa M., Udler, Miriam, Leong, Aaron, Kaur, Varindepal, Flannick, Jason, Jørgensen, Torben, Linneberg, Allan, Jørgensen, Marit E., Witte, Daniel R., Christensen, Cramer, Brandslund, Ivan, Appel, Emil V., Scott, Robert A., Luan, Jian’an, Langenberg, Claudia, Wareham, Nicholas J., Pedersen, Oluf, Zorzano, Antonio, Florez, Jose C, Hansen, Torben, Ferrer, Jorge, Mercader, Josep Maria, Torrents, David

“…The reanalysis of existing GWAS data represents a powerful and cost-effective opportunity to gain insights into the genetics of complex diseases. By…”
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Correction: Hypertension genetic risk score is associated with burden of coronary heart disease among patients referred for coronary angiography by Krogager, Maria Lukács, Skals, Regitze Kuhr, Appel, Emil Vincent R, Schnurr, Theresia M, Engelbrechtsen, Line, Have, Christian Theil, Pedersen, Oluf, Engstrøm, Thomas, Roden, Dan M, Gislason, Gunnar, Poulsen, Henrik Enghusen, Køber, Lars, Stender, Steen, Hansen, Torben, Grarup, Niels, Andersson, Charlotte, Torp-Pedersen, Christian, Weeke, Peter E

“…[This corrects the article DOI: 10.1371/journal.pone.0208645.]…”
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Hypertension genetic risk score is associated with burden of coronary heart disease among patients referred for coronary angiography by Lukács Krogager, Maria, Skals, Regitze Kuhr, Appel, Emil Vincent R, Schnurr, Theresia M, Engelbrechtsen, Line, Have, Christian Theil, Pedersen, Oluf, Engstrøm, Thomas, Roden, Dan M, Gislason, Gunnar, Poulsen, Henrik Enghusen, Køber, Lars, Stender, Steen, Hansen, Torben, Grarup, Niels, Andersson, Charlotte, Torp-Pedersen, Christian, Weeke, Peter E

“…Recent GWAS studies have identified more than 300 SNPs associated with variation in blood pressure. We investigated whether a genetic risk score constructed…”
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Genetic determinants of glycated hemoglobin levels in the Greenlandic Inuit population by Appel, Emil V R, Moltke, Ida, Jørgensen, Marit E, Bjerregaard, Peter, Linneberg, Allan, Pedersen, Oluf, Albrechtsen, Anders, Hansen, Torben, Grarup, Niels

“…We previously showed that a common genetic variant leads to a remarkably increased risk of type 2 diabetes (T2D) in the small and historically isolated…”
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Association of genetic variants previously implicated in coronary artery disease with age at onset of coronary artery disease requiring revascularizations by Andersson, Charlotte, Lukács Krogager, Maria, Kuhr Skals, Regitze, Rosenbaum Appel, Emil Vincent, Theil Have, Christian, Grarup, Niels, Pedersen, Oluf, Jeppesen, Jørgen L, Pedersen, Ole Dyg, Dominguez, Helena, Dixen, Ulrik, Engstrøm, Thomas, Tønder, Niels, Roden, Dan M, Stender, Steen, Gislason, Gunnar H, Enghusen-Poulsen, Henrik, Hansen, Torben, Køber, Lars, Torp-Pedersen, Christian, Weeke, Peter E

“…The relation between burden of risk factors, familial coronary artery disease (CAD), and known genetic variants underlying CAD and low-density lipoprotein…”
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The type 2 diabetes risk allele of TMEM154-rs6813195 associates with decreased beta cell function in a study of 6,486 Danes by Harder, Marie Neergaard, Appel, Emil Vincent Rosenbaum, Grarup, Niels, Gjesing, Anette Prior, Ahluwalia, Tarunveer S, Jørgensen, Torben, Christensen, Cramer, Brandslund, Ivan, Linneberg, Allan, Sørensen, Thorkild I A, Pedersen, Oluf, Hansen, Torben

“…A trans-ethnic meta-analysis of type 2 diabetes genome-wide association studies has identified seven novel susceptibility variants in or near TMEM154,…”
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Genetic insights into resting heart rate and its role in cardiovascular disease by van de Vegte, Yordi J., Eppinga, Ruben N., van der Ende, M. Yldau, Hagemeijer, Yanick P., Mahendran, Yuvaraj, Tan, Vanessa Y., Ntalla, Ioanna, Brody, Jennifer A., Lecoeur, Cecile, Hwang, Shih-Jen, Mononen, Nina, Auro, Kirsi, Jackson, Anne U., Zeng, Linyao, Nethander, Maria, Pechlivanis, Sonali, Qi, Lu, Zhao, Wei, Rizzi, Federica, Tanaka, Toshiko, Robino, Antonietta, Lange, Leslie, Zhang, Weihua, Guo, Xiuqing, Lin, Henry J., Noordam, Raymond, Milaneschi, Yuri, Schraut, Katharina E., den Hoed, Marcel, Trompet, Stella, van den Berg, Marten E., Pistis, Giorgio, Weiss, Stefan, Nolte, Ilja M., Lyytikäinen, Leo-Pekka, Iribarren, Carlos, Ring, Susan M., de Vries, Paul S., Sever, Peter, Linneberg, Allan, Bottinger, Erwin P., Sotoodehnia, Nona, Kolcic, Ivana, Gudbjartsson, Daniel F., Newton-Cheh, Christopher H., Nikus, Kjell, Salo, Perttu, Peyser, Patricia A., Schunkert, Heribert, Lorentzon, Mattias, Lahti, Jari, Rao, Dabeeru C., Cornelis, Marilyn C., Faul, Jessica D., Smith, Jennifer A., Concas, Maria Pina, Sinagra, Gianfranco, Delgado, Graciela E., Foco, Luisa, Melander, Olle, de Mutsert, Renée, de Geus, Eco J. C., Joshi, Peter K., Macfarlane, Peter W., Tan, Nicholas, Felix, Stephan B., Quek, Debra Q., Ingelsson, Martin, Raitakari, Olli T., Timpson, Nicholas J., Morrison, Alanna C., Heckbert, Susan R., Hayward, Caroline, Stefansson, Kari, Wareham, Nicholas J., van Duijn, Cornelia M., Feitosa, Mary F., Boehnke, Michael, Kardia, Sharon L. R., Ohlsson, Claes, Eriksson, Johan G., Moebus, Susanne, Cusi, Daniele, Girotto, Giorgia, Kääb, Stefan, Peters, Annette, März, Winfried, Smith, J. Gustav, Mook-Kanamori, Dennis O., Gyllensten, Ulf, Wilson, James F., Burgess, Stephen, Sundström, Johan, Lieb, Wolfgang, Eijgelsheim, Mark, Cheng, Ching-Yu, Dörr, Marcus, Wong, Tien-Yin, Riese, Harriette, Verweij, Niek

“…Resting heart rate is associated with cardiovascular diseases and mortality in observational and Mendelian randomization studies. The aims of this study are to…”
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Prospective Studies Exploring the Possible Impact of an ID3 Polymorphism on Changes in Obesity Measures by Svendstrup, Mathilde, Appel, Emil V.R., Sandholt, Camilla H., Ahluwalia, Tarunveer S., Ängquist, Lars H., Thuesen, Betina H., Jørgensen, Marit E., Pedersen, Oluf, Grarup, Niels, Hansen, Torben, Sørensen, Thorkild I.A., Vestergaard, Henrik

“…Objective Changes in fat mass depend on adipogenesis and angiogenesis, mechanisms regulated by the inhibitor of differentiation‐3 (ID3). Id3 knockout mice…”
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Genetic Susceptibility for Childhood BMI has no Impact on Weight Loss Following Lifestyle Intervention in Danish Children by Hollensted, Mette, Fogh, Mette, Schnurr, Theresia M., Kloppenborg, Julie T., Have, Christian T., Ruest Haarmark Nielsen, Tenna, Rask, Johanne, Asp Vonsild Lund, Morten, Frithioff‐Bøjsøe, Christine, Østergaard Johansen, Mia, Vincent Rosenbaum Appel, Emil, Mahendran, Yuvaraj, Grarup, Niels, Kadarmideen, Haja N., Pedersen, Oluf, Holm, Jens‐Christian, Hansen, Torben

“…Objective This study aimed to investigate the effect of a genetic risk score (GRS) comprising 15 single‐nucleotide polymorphisms, previously shown to associate…”
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An adult-based insulin resistance genetic risk score associates with insulin resistance, metabolic traits and altered fat distribution in Danish children and adolescents who are overweight or obese by Graae, Anne-Sofie, Hollensted, Mette, Kloppenborg, Julie T., Mahendran, Yuvaraj, Schnurr, Theresia M., Appel, Emil Vincent R., Rask, Johanne, Nielsen, Tenna R. H., Johansen, Mia Ø., Linneberg, Allan, Jørgensen, Marit E., Grarup, Niels, Kadarmideen, Haja N., Holst, Birgitte, Pedersen, Oluf, Holm, Jens-Christian, Hansen, Torben

“…Aims/hypothesis A genetic risk score (GRS) consisting of 53 insulin resistance variants (GRS 53 ) was recently demonstrated to associate with insulin…”
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Author Correction: Cohort-wide deep whole genome sequencing and the allelic architecture of complex traits by Gilly, Arthur, Suveges, Daniel, Kuchenbaecker, Karoline, Pollard, Martin, Southam, Lorraine, Hatzikotoulas, Konstantinos, Farmaki, Aliki-Eleni, Bjornland, Thea, Waples, Ryan, Appel, Emil V. R., Casalone, Elisabetta, Melloni, Giorgio, Kilian, Britt, Rayner, Nigel W., Ntalla, Ioanna, Kundu, Kousik, Walter, Klaudia, Danesh, John, Butterworth, Adam, Barroso, Inês, Tsafantakis, Emmanouil, Dedoussis, George, Moltke, Ida, Zeggini, Eleftheria

“…The original version of this Article contained an error in Fig. 2. In panel a, the two legend items “rare” and “common” were inadvertently swapped. This has…”
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Re-analysis of public genetic data reveals a rare X-chromosomal variant associated with type 2 diabetes by Bonàs Guarch, Sílvia, Guindo-Martínez, Marta, Miguel-Escalada, Irene, Grarup, Niels, Sebastián Muñoz, David, Rodriguez-Fos, Elias, Sánchez, Friman, Planas-Fèlix, Mercè, Cortes-Sánchez, Paula, González, Santi, Timshel, Pascal, Pers, Tune H, Morgan, Claire C, Moran, Ignasi, Atla, Goutham, González, Juan Ramón, Puiggros, Montserrat, Martí, Jonathan, Andersson, Ehm A, Díaz, Carlos, Badia, Rosa M, Udler, Miriam, Leong, Aaron, Kaur, Varindepal, Flannick, Jason, Jørgensen, Torben, Linneberg, Allan, Jørgensen, Marit E, Witte, Daniel R, Christensen, Cramer, Brandslund, Ivan, Appel, Emil V, Scott, Robert A, Luan, Jian'an, Langenberg, Claudia, Wareham, Nicholas J, Pedersen, Oluf, Zorzano Olarte, Antonio, Florez, Jose C, Hansen, Torben

“…The reanalysis of existing GWAS data represents a powerful and cost-effective opportunity to gain insights into the genetics of complex diseases. By…”
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Publisher Correction: Re-analysis of public genetic data reveals a rare X-chromosomal variant associated with type 2 diabetes by Bonàs-Guarch, Sílvia, Guindo-Martínez, Marta, Miguel-Escalada, Irene, Grarup, Niels, Sebastian, David, Rodriguez-Fos, Elias, Sánchez, Friman, Planas-Fèlix, Mercè, Cortes-Sánchez, Paula, González, Santi, Timshel, Pascal, Pers, Tune H., Morgan, Claire C., Moran, Ignasi, Atla, Goutham, González, Juan R., Puiggros, Montserrat, Martí, Jonathan, Andersson, Ehm A., Díaz, Carlos, Badia, Rosa M., Udler, Miriam, Leong, Aaron, Kaur, Varindepal, Flannick, Jason, Jørgensen, Torben, Linneberg, Allan, Jørgensen, Marit E., Witte, Daniel R., Christensen, Cramer, Brandslund, Ivan, Appel, Emil V., Scott, Robert A., Luan, Jian’an, Langenberg, Claudia, Wareham, Nicholas J., Pedersen, Oluf, Zorzano, Antonio, Florez, Jose C, Hansen, Torben, Ferrer, Jorge, Mercader, Josep Maria, Torrents, David

“…In the originally published version of this Article, the affiliation details for Santi González, Jian’an Luan and Claudia Langenberg were inadvertently…”
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