Search Results - "Appaji Rao, N"

Structure–function relationship in serine hydroxymethyltransferase by Appaji Rao, N., Ambili, M., Jala, Venkatakrishna R., Subramanya, H.S., Savithri, H.S.

“…Serine hydroxymethyltransferase (SHMT), a pyridoxal-5′-phosphate (PLP)-dependent enzyme catalyzes the tetrahydrofolate (H 4-folate)-dependent retro-aldol…”
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Importance of tyrosine residues of Bacillus stearothermophilus serine hydroxymethyltransferase in cofactor binding and l-allo-Thr cleavage by Bhavani, B.S, Rajaram, V, Bisht, Shveta, Kaul, Purnima, Prakash, V, Murthy, M.R.N, Appaji Rao, N, Savithri, H.S

“…Serine hydroxymethyltransferase (SHMT) from Bacillus stearothermophilus (bsSHMT) is a pyridoxal 5'-phosphate-dependent enzyme that catalyses the conversion of…”
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Structure determination and biochemical studies on Bacillus stearothermophilus E53Q serine hydroxymethyltransferase and its complexes provide insights on function and enzyme memory by Rajaram, V., Bhavani, B. S., Kaul, Purnima, Prakash, V., Appaji Rao, N., Savithri, H. S., Murthy, M. R. N.

“…Serine hydroxymethyltransferase (SHMT) belongs to the α‐family of pyridoxal 5′‐phosphate‐dependent enzymes and catalyzes the reversible conversion of l‐Ser and…”
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Role of Lys-226 in the Catalytic Mechanism of Bacillus Stearothermophilus Serine HydroxymethyltransferaseCrystal Structure and Kinetic Studies by Bhavani, Siddegowda, Trivedi, V, Jala, V. R, Subramanya, H. S, Kaul, Purnima, Prakash, V, Appaji Rao, N, Savithri, H. S

“…Serine hydroxymethyltransferase (SHMT), a pyridoxal 5‘-phosphate (PLP)-dependent enzyme catalyzes the reversible conversion of l-Ser and…”
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Reproductive Behavior and Health in Consanguineous Marriages by Bittles, Alan H., Mason, William M., Greene, Jennifer, Rao, N. Appaji

“…In many regions of Asia and Africa, consanguineous marriages currently account for approximately 20 to 50% of all unions, and preliminary observations indicate…”
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Crystal Structure of Escherichia coli Diaminopropionate Ammonia-lyase Reveals Mechanism of Enzyme Activation and Catalysis by Bisht, Shveta, Rajaram, Venkatesan, Bharath, Sakshibeedu R., Kalyani, Josyula Nitya, Khan, Farida, Rao, Appaji N., Savithri, Handanahal S., Murthy, Mathur R.N.

“…Pyridoxal 5′-phosphate (PLP)-dependent enzymes utilize the unique chemistry of a pyridine ring to carry out diverse reactions involving amino acids…”
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NR Moudgal – A pioneer in the development of immunocontraceptive approaches by Rao, AJ, Rao, Appaji

“…Professor NR Moudgal, an eminent reproductive biologist and endocrinologist and a former professor at the Department of Biochemistry, Indian Institute of…”
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Structural and functional studies of Bacillus stearothermophilus serine hydroxymethyltransferase: the role of Asn(341), Tyr(60) and Phe(351) in tetrahydrofolate binding by Pai, Vinitha R, Rajaram, V, Bisht, Shveta, Bhavani, B S, Rao, N Appaji, Murthy, M R N, Savithri, H S

“…SHMT (serine hydoxymethyltransferase), a type I pyridoxal 5'-phosphate-dependent enzyme, catalyses the conversion of L-serine and THF (tetrahydrofolate) into…”
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Crystal structure of binary and ternary complexes of serine hydroxymethyltransferase from Bacillus stearothermophilus: insights into the catalytic mechanism by Trivedi, Vishal, Gupta, Amrita, Jala, Venkatakrishna R, Saravanan, P, Rao, G S Jagannatha, Rao, N Appaji, Savithri, Handanahal S, Subramanya, Hosahalli S

“…Serine hydroxymethyltransferase (SHMT), a member of the alpha-class of pyridoxal phosphate-dependent enzymes, catalyzes the reversible conversion of serine to…”
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The role of Glu74 and Tyr82 in the reaction catalyzed by sheep liver cytosolic serine hydroxymethyltransferase by Rao, J. V. Krishna, Prakash, V., Rao, N. Appaji, Savithri, H. S.

“…The three‐dimensional structures of human and rabbit liver cytosolic recombinant serine hydroxymethyltransferases (hcSHMT and rcSHMT) revealed that E75 and Y83…”
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Identification of the active-site peptide of 2,3-dihydroxybenzoic acid decarboxylase from Aspergillus oryzae by Santha, R., Appaji Rao, N., Vaidyanathan, C.S.

“…The non-oxidative decarboxylation of aromatic acids is a poorly understood reaction. The transformation of 2,3-dihydroxybenzoic acid to catechol in the fungal…”
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Characterization of recombinant diaminopropionate ammonia-lyase from Escherichia coli and Salmonella typhimurium by Khan, Farida, Jala, Venkatakrishna R, Rao, N.Appaji, Savithri, H.S

“…Diaminopropionate ammonia-lyase gene from Escherichia coli and Salmonella typhimurium was cloned and the overexpressed enzymes were purified to homogeneity…”
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change in reaction specificity of sheep liver serine hydroxymethyltransferase induction of NADH oxidation upon mutation of His230 to Tyr by Talwar, R, Appaji Rao, N, Savithri, H.S

“…Both serine hydroxymethyltransferase and aspartate aminotransferase belong to the alpha-class of pyridoxal-5'-phosphate (pyridoxalP)-dependent enzymes but…”
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Overexpression and characterization of dimeric and tetrameric forms of recombinant serine hydroxymethyltransferase from Bacillus stearothermophilus by Jala, Venkatakrishna R, Prakash, V, Rao, N Appaji, Savithri, H S

“…Serine hydroxymethyltransferase (SHMT), a pyridoxal-5' -phosphate (PLP) dependent enzyme catalyzes the interconversion of L-Ser and Gly using tetrahydrofolate…”
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Crystal Structure of Binary and Ternary Complexes of Serine Hydroxymethyltransferase from Bacillus stearothermophilus by Trivedi, Vishal, Gupta, Amrita, Jala, Venkatakrishna R., Saravanan, P., Rao, G.S. Jagannatha, Rao, N. Appaji, Savithri, Handanahal S., Subramanya, Hosahalli S.

“…Serine hydroxymethyltransferase (SHMT), a member of the α-class of pyridoxal phosphate-dependent enzymes, catalyzes the reversible conversion of serine to…”
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Asp-89: a critical residue in maintaining the oligomeric structure of sheep liver cytosolic serine hydroxymethyltransferase by Krishna Rao, J V, Jagath, J R, Sharma, B, Appaji Rao, N, Savithri, H S

“…Aspartate residues function as proton acceptors in catalysis and are involved in ionic interactions stabilizing subunit assembly. In an attempt to unravel the…”
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Role of pro-297 in the catalytic mechanism of sheep liver serine hydroxymethyltransferase by Talwar, R, Leelavathy, V, Krishna Rao, J V, Appaji Rao, N, Savithri, H S

“…Serine hydroxymethyltransferase belongs to the alpha class of pyridoxal-5'-phosphate enzymes along with aspartate aminotransferase. Recent reports on the…”
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Disruption of distal interactions of Arg 262 and of substrate binding to Ser 52 affect catalysis of sheep liver cytosolic serine hydroxymethyltransferase by Jala, Venkatakrishna Rao, Ambili, M, Prakash, V, Rao, N Appaji, Savithri, H S

“…The crystal structure of human liver cytosolic recombinant serine hydroxymethyltransferase (hcSHMT) suggested that Ser53 and Arg 263 could participate in the…”
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Overexpression and characterization of dimeric and tetrameric forms of recombinant serine hydroxymethyltransferase fromBacillus stearothermophilus by Jala, Venkatakrishna R., Prakash, V., Rao, N. Appaji, Savithri, H. S.

“…Serine hydroxymethyltransferase (SHMT), a pyridoxal-5'-phosphate (PLP) dependent enzyme catalyzes the interconversion of L-Ser and Gly using tetrahydrofolate…”
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Predictive testing for familial adenomatous polyposis in a rural South Indian community by Savithri, Hs, Venkatesha Murthy, Hs, Baskaran, G, Appaji Rao, N, Kool, D, Edkins, E, Wang, W, Bittles, Ah

“…During the course of genome studies in a rural community in the South Indian state of Karnataka, DNA‐based investigations and counselling for familial…”
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