Retinal Perivasculitis in an Immunocompetent Patient With Systemic Herpes Simplex Infection

To describe a case of retinal perivasculitis in an immunocompetent patient with systemic herpes simplex infection. Polymerase chain reaction amplifications were performed for aqueous and blood samples using primers specific for the following members of the herpesvirus family: cytomegalovirus, Epstei...

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Bibliographic Details
Published in:	American journal of ophthalmology Vol. 123; no. 5; pp. 699 - 702
Main Authors:	Chatzoulis, Dimitrios M., Theodosiadis, Panagiotis G., Apostolopoulos, Michalis N., Drakoulis, Nikolaos, Markomichelakis, Nikolaos N.
Format:	Journal Article
Language:	English
Published:	New York, NY Elsevier Inc 01-05-1997 Elsevier Elsevier Limited
Subjects:	Acyclovir - therapeutic use Antiviral Agents - therapeutic use Aqueous Humor - virology Biological and medical sciences DNA, Viral - analysis Eye Infections, Viral - diagnosis Eye Infections, Viral - drug therapy Eye Infections, Viral - etiology Female Fluorescein Angiography Fundus Oculi Herpes Simplex - diagnosis Herpes Simplex - drug therapy Herpes Simplex - etiology Herpesvirus 1, Human - genetics Herpesvirus 1, Human - isolation & purification Human viral diseases Humans Immunocompetence Infectious diseases Medical sciences Middle Aged Miscellaneous Polymerase Chain Reaction Retinal Vein - pathology Retinitis - diagnosis Retinitis - drug therapy Retinitis - virology Vasculitis - diagnosis Vasculitis - drug therapy Vasculitis - virology Viral diseases Viremia - virology Human Retinopathy Herpesviridae Alphaherpesvirinae Herpes Cardiovascular disease Retina Systemic Infection Vascular disease Virus Case study Polymerase chain reaction Eye disease Viral disease Complication Herpesvirus hominis Diagnosis Molecular biology
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Summary:	To describe a case of retinal perivasculitis in an immunocompetent patient with systemic herpes simplex infection. Polymerase chain reaction amplifications were performed for aqueous and blood samples using primers specific for the following members of the herpesvirus family: cytomegalovirus, Epstein-Barr virus, herpes simplex virus (types 1 and 2), and varicella-zoster virus. The patient was placed on intravenous acyclovir and systemic corticosteroids. A positive polymerase chain reaction signal was found only for herpes simplex virus type 1. Vision in the left eye improved from light perception to 20/25, and signs of retinal perivasculitis resolved. The use of molecular diagnostic modalities in clinical practice may aid in determining infectious etiologies in patients with atypical clinical manifestations.
Bibliography:	ObjectType-Case Study-2 SourceType-Scholarly Journals-1 ObjectType-Feature-4 content type line 23 ObjectType-Report-1 ObjectType-Article-3
ISSN:	0002-9394 1879-1891
DOI:	10.1016/S0002-9394(14)71089-X