Search Results - "Aposhian, HV"
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1
Arsenic Toxicology: Five Questions
Published in Chemical research in toxicology (01-01-2006)Get full text
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A review of the enzymology of arsenic metabolism and a new potential role of hydrogen peroxide in the detoxication of the trivalent arsenic species
Published in Toxicology and Applied Pharmacology (01-08-2004)“…This laboratory has studied the enzymology involved in the biotransformation of inorganic arsenic to dimethylarsinous acid (DMA(III)) and in human studies…”
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3
Enzymatic methylation of arsenic species and other new approaches to arsenic toxicity
Published in Annual review of pharmacology and toxicology (01-01-1997)“…Arsenic metabolism has typically been studied by administering arsenate or arsenite into animals and humans and then studying the metabolites excreted in the…”
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The metabolism of inorganic arsenic oxides, gallium arsenide, and arsine: a toxicochemical review
Published in Toxicology and applied pharmacology (15-12-2003)“…The aim of this review is to compare the metabolism, chemistry, and biological effects to determine if either of the industrial arsenicals (arsine and gallium…”
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5
Monomethylarsonous Acid (MMAIII) Is More Toxic Than Arsenite in Chang Human Hepatocytes
Published in Toxicology and applied pharmacology (01-03-2000)“…Methylation has been considered to be the primary detoxication pathway of inorganic arsenic. Inorganic arsenic is methylated by many, but not all animal…”
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Monomethylarsonous Acid (MMAIII) and Arsenite: LD50 in Hamsters and In Vitro Inhibition of Pyruvate Dehydrogenase
Published in Chemical research in toxicology (18-06-2001)“…Monomethylarsonous acid (MMAIII), a metabolite of inorganic arsenic, has received very little attention from investigators of arsenic metabolism in humans…”
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Speciation of Key Arsenic Metabolic Intermediates in Human Urine
Published in Analytical chemistry (Washington) (01-11-2000)“…Biomethylation is the major human metabolic pathway for inorganic arsenic, and the speciation of arsenic metabolites is essential to a better understanding of…”
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8
Chronic Arsenic Poisoning from Burning High-Arsenic-Containing Coal in Guizhou, China
Published in Environmental health perspectives (01-02-2002)“…Arsenic is an environmental hazard and the reduction of drinking water arsenic levels is under consideration. People are exposed to arsenic not only through…”
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Variability in human metabolism of arsenic
Published in Environmental research (01-06-2003)“…Estimating the nature and extent of human cancer risks due to arsenic (As) in drinking water is currently of great concern, since millions of persons worldwide…”
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Oxidation and detoxification of trivalent arsenic species
Published in Toxicology and applied pharmacology (15-11-2003)“…Arsenic compounds with a +3 oxidation state are more toxic than analogous compounds with a +5 oxidation state, for example, arsenite versus arsenate,…”
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Human Monomethylarsonic Acid (MMAV) Reductase Is a Member of the Glutathione-S-transferase Superfamily
Published in Chemical research in toxicology (01-08-2001)“…The drinking of water containing large amounts of inorganic arsenic is a worldwide major public health problem because of arsenic carcinogenicity. Yet an…”
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Enzymatic reduction of arsenic compounds in mammalian systems: the rate-limiting enzyme of rabbit liver arsenic biotransformation is MMA(V) reductase
Published in Chemical research in toxicology (01-12-1999)“…A unique enzyme, MMA(V) reductase, has been partially purified from rabbit liver by using DEAE-cellulose, carboxymethylcellulose, and red dye ligand…”
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13
Determination of Monomethylarsonous Acid, a Key Arsenic Methylation Intermediate, in Human Urine
Published in Environmental health perspectives (01-11-2000)“…In this study we report on the finding of monomethylarsonous acid [MMA(III)] in human urine. This newly identified arsenic species is a key intermediate in the…”
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14
The enigma of arsenic carcinogenesis : Role of metabolism
Published in Toxicological sciences (01-05-1999)“…Inorganic arsenic is considered a high-priority hazard, particularly because of its potential to be a human carcinogen. In exposed human populations, arsenic…”
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15
Arsenate Reductase II. Purine Nucleoside Phosphorylase in the Presence of Dihydrolipoic Acid Is a Route for Reduction of Arsenate to Arsenite in Mammalian Systems
Published in Chemical research in toxicology (01-05-2002)“…An arsenate reductase has been partially purified from human liver using ion exchange, molecular exclusion, hydroxyapatite chromatography, preparative…”
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Enzymatic Reduction of Arsenic Compounds in Mammalian Systems: Reduction of Arsenate to Arsenite by Human Liver Arsenate Reductase
Published in Chemical research in toxicology (01-01-2000)“…An arsenate (AsV) reductase has been partially purified from human liver. Its apparent molecular mass is approximately 72 kDa. The enzyme required a thiol and…”
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Occurrence of Monomethylarsonous Acid in Urine of Humans Exposed to Inorganic Arsenic
Published in Chemical research in toxicology (01-08-2000)“…Monomethylarsonous acid (MMAIII) has been detected for the first time in the urine of some humans exposed to inorganic arsenic in their drinking water. Our…”
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Polymorphisms in the Human Monomethylarsonic Acid (MMAV) Reductase/hGSTO1 Gene and Changes in Urinary Arsenic Profiles
Published in Chemical research in toxicology (01-12-2003)“…Large interindividual variability in urinary arsenic profiles, following chronic inorganic arsenic exposure, is well-known in humans. To understand this…”
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Interactions of Sodium Selenite, Glutathione, Arsenic Species, and Omega Class Human Glutathione Transferase
Published in Chemical research in toxicology (01-08-2005)“…Human monomethylarsenate reductase [MMA(V) reductase] and human glutathione S-transferase omega 1-1 (hGSTO1-1) [because MMA(V) reductase and hGSTO1-1 are…”
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Structural Basis of the Antagonism between Inorganic Mercury and Selenium in Mammals
Published in Chemical research in toxicology (01-11-2000)“…Mercuric chloride toxicity in mammals can be overcome by co-administration of sodium selenite. We report a study of the mutual detoxification product in rabbit…”
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