Search Results - "Aposhian, HV"

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    A review of the enzymology of arsenic metabolism and a new potential role of hydrogen peroxide in the detoxication of the trivalent arsenic species by Vasken Aposhian, H, Zakharyan, Robert A, Avram, Mihaela D, Sampayo-Reyes, Adriana, Wollenberg, Michael L

    Published in Toxicology and Applied Pharmacology (01-08-2004)
    “…This laboratory has studied the enzymology involved in the biotransformation of inorganic arsenic to dimethylarsinous acid (DMA(III)) and in human studies…”
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    Book Review Journal Article
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    Enzymatic methylation of arsenic species and other new approaches to arsenic toxicity by Aposhian, H V

    “…Arsenic metabolism has typically been studied by administering arsenate or arsenite into animals and humans and then studying the metabolites excreted in the…”
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    Journal Article
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    The metabolism of inorganic arsenic oxides, gallium arsenide, and arsine: a toxicochemical review by Carter, Dean E, Aposhian, H.Vasken, Gandolfi, A.Jay

    Published in Toxicology and applied pharmacology (15-12-2003)
    “…The aim of this review is to compare the metabolism, chemistry, and biological effects to determine if either of the industrial arsenicals (arsine and gallium…”
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    Journal Article
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    Monomethylarsonous Acid (MMAIII) Is More Toxic Than Arsenite in Chang Human Hepatocytes by Petrick, Jay S., Ayala-Fierro, Felix, Cullen, William R., Carter, Dean E., Vasken Aposhian, H.

    Published in Toxicology and applied pharmacology (01-03-2000)
    “…Methylation has been considered to be the primary detoxication pathway of inorganic arsenic. Inorganic arsenic is methylated by many, but not all animal…”
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    Journal Article
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    Monomethylarsonous Acid (MMAIII) and Arsenite:  LD50 in Hamsters and In Vitro Inhibition of Pyruvate Dehydrogenase by Petrick, Jay S, Jagadish, Bhumasamudram, Mash, Eugene A, Aposhian, H. Vasken

    Published in Chemical research in toxicology (18-06-2001)
    “…Monomethylarsonous acid (MMAIII), a metabolite of inorganic arsenic, has received very little attention from investigators of arsenic metabolism in humans…”
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    Journal Article
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    Speciation of Key Arsenic Metabolic Intermediates in Human Urine by Le, X. Chris, Lu, Xiufen, Ma, Mingsheng, Cullen, William R, Aposhian, H. Vasken, Zheng, Baoshan

    Published in Analytical chemistry (Washington) (01-11-2000)
    “…Biomethylation is the major human metabolic pathway for inorganic arsenic, and the speciation of arsenic metabolites is essential to a better understanding of…”
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    Journal Article
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    Chronic Arsenic Poisoning from Burning High-Arsenic-Containing Coal in Guizhou, China by Liu, Jie, Zheng, Baoshan, Aposhian, H. Vasken, Zhou, Yunshu, Chen, Ming-Liang, Zhang, Aihua, Waalkes, Michael P.

    Published in Environmental health perspectives (01-02-2002)
    “…Arsenic is an environmental hazard and the reduction of drinking water arsenic levels is under consideration. People are exposed to arsenic not only through…”
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    Journal Article
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    Variability in human metabolism of arsenic by Loffredo, Christopher A., Aposhian, H.Vasken, Cebrian, Mariano E., Yamauchi, Hiroshi, Silbergeld, Ellen K.

    Published in Environmental research (01-06-2003)
    “…Estimating the nature and extent of human cancer risks due to arsenic (As) in drinking water is currently of great concern, since millions of persons worldwide…”
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    Journal Article
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    Oxidation and detoxification of trivalent arsenic species by Aposhian, H.Vasken, Zakharyan, Robert A., Avram, Mihaela D., Kopplin, Michael J., Wollenberg, Michael L.

    Published in Toxicology and applied pharmacology (15-11-2003)
    “…Arsenic compounds with a +3 oxidation state are more toxic than analogous compounds with a +5 oxidation state, for example, arsenite versus arsenate,…”
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    Journal Article
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    Human Monomethylarsonic Acid (MMAV) Reductase Is a Member of the Glutathione-S-transferase Superfamily by Zakharyan, Robert A, Sampayo-Reyes, Adriana, Healy, Sheila M, Tsaprailis, George, Board, Philip G, Liebler, Daniel C, Aposhian, H. Vasken

    Published in Chemical research in toxicology (01-08-2001)
    “…The drinking of water containing large amounts of inorganic arsenic is a worldwide major public health problem because of arsenic carcinogenicity. Yet an…”
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    Journal Article
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    Enzymatic reduction of arsenic compounds in mammalian systems: the rate-limiting enzyme of rabbit liver arsenic biotransformation is MMA(V) reductase by Zakharyan, R A, Aposhian, H V

    Published in Chemical research in toxicology (01-12-1999)
    “…A unique enzyme, MMA(V) reductase, has been partially purified from rabbit liver by using DEAE-cellulose, carboxymethylcellulose, and red dye ligand…”
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    Journal Article
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    Determination of Monomethylarsonous Acid, a Key Arsenic Methylation Intermediate, in Human Urine by Le, X. Chris, Ma, Mingsheng, Lu, Xiufen, Cullen, William R., Aposhian, H. Vasken, Zheng, Baoshan

    Published in Environmental health perspectives (01-11-2000)
    “…In this study we report on the finding of monomethylarsonous acid [MMA(III)] in human urine. This newly identified arsenic species is a key intermediate in the…”
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    Journal Article
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    The enigma of arsenic carcinogenesis : Role of metabolism by GOERING, P. L, APOSHIAN, H. V, MASS, M. J, CEBRIAN, M, BECK, B. D, WAALKES, M. P

    Published in Toxicological sciences (01-05-1999)
    “…Inorganic arsenic is considered a high-priority hazard, particularly because of its potential to be a human carcinogen. In exposed human populations, arsenic…”
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    Journal Article
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    Arsenate Reductase II. Purine Nucleoside Phosphorylase in the Presence of Dihydrolipoic Acid Is a Route for Reduction of Arsenate to Arsenite in Mammalian Systems by Radabaugh, Timothy R, Sampayo-Reyes, Adriana, Zakharyan, Robert A, Aposhian, H. Vasken

    Published in Chemical research in toxicology (01-05-2002)
    “…An arsenate reductase has been partially purified from human liver using ion exchange, molecular exclusion, hydroxyapatite chromatography, preparative…”
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    Journal Article
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    Enzymatic Reduction of Arsenic Compounds in Mammalian Systems:  Reduction of Arsenate to Arsenite by Human Liver Arsenate Reductase by Radabaugh, Timothy R, Aposhian, H. Vasken

    Published in Chemical research in toxicology (01-01-2000)
    “…An arsenate (AsV) reductase has been partially purified from human liver. Its apparent molecular mass is approximately 72 kDa. The enzyme required a thiol and…”
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    Journal Article
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    Interactions of Sodium Selenite, Glutathione, Arsenic Species, and Omega Class Human Glutathione Transferase by Zakharyan, Robert A, Tsaprailis, George, Chowdhury, Uttam K, Hernandez, Alba, Aposhian, H. Vasken

    Published in Chemical research in toxicology (01-08-2005)
    “…Human monomethylarsenate reductase [MMA(V) reductase] and human glutathione S-transferase omega 1-1 (hGSTO1-1) [because MMA(V) reductase and hGSTO1-1 are…”
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    Journal Article
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    Structural Basis of the Antagonism between Inorganic Mercury and Selenium in Mammals by Gailer, Jürgen, George, Graham N, Pickering, Ingrid J, Madden, Sean, Prince, Roger C, Yu, Eileen Y, Denton, M. Bonner, Younis, Husam S, Aposhian, H. Vasken

    Published in Chemical research in toxicology (01-11-2000)
    “…Mercuric chloride toxicity in mammals can be overcome by co-administration of sodium selenite. We report a study of the mutual detoxification product in rabbit…”
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    Journal Article