Search Results - "Aponte, Angel M"

The physiological role of mitochondrial calcium revealed by mice lacking the mitochondrial calcium uniporter by Pan, Xin, Liu, Jie, Nguyen, Tiffany, Liu, Chengyu, Sun, Junhui, Teng, Yanjie, Fergusson, Maria M., Rovira, Ilsa I., Allen, Michele, Springer, Danielle A., Aponte, Angel M., Gucek, Marjan, Balaban, Robert S., Murphy, Elizabeth, Finkel, Toren

“…Mitochondrial calcium has been postulated to regulate a wide range of processes from bioenergetics to cell death. Here, we characterize a mouse model that…”
Get full text

Molecular studies into cell biological role of Copine-4 in Retinal Ganglion Cells by Goel, Manvi, Aponte, Angel M, Wistow, Graeme, Badea, Tudor C

“…The molecular mechanisms underlying morphological diversity in retinal cell types are poorly understood. We have previously reported that several members of…”
Get full text

The Mammalian Target of Rapamycin (mTOR) Pathway Regulates Mitochondrial Oxygen Consumption and Oxidative Capacity by Schieke, Stefan M., Phillips, Darci, McCoy, J. Philip, Aponte, Angel M., Shen, Rong-Fong, Balaban, Robert S., Finkel, Toren

“…Metabolic rate and the subsequent production of reactive oxygen species are thought to contribute to the rate of aging in a wide range of species. The target…”
Get full text

Loss of endocytosis-associated RabGEF1 causes aberrant morphogenesis and altered autophagy in photoreceptors leading to retinal degeneration by Hargrove-Grimes, Passley, Mondal, Anupam K, Gumerson, Jessica, Nellissery, Jacob, Aponte, Angel M, Gieser, Linn, Qian, Haohua, Fariss, Robert N, Bonifacino, Juan S, Li, Tiansen, Swaroop, Anand

“…Rab-GTPases and associated effectors mediate cargo transport through the endomembrane system of eukaryotic cells, regulating key processes such as membrane…”
Get full text

A New Structural Model of Apolipoprotein B100 Based on Computational Modeling and Cross Linking by Jeiran, Kianoush, Gordon, Scott M., Sviridov, Denis O., Aponte, Angel M., Haymond, Amanda, Piszczek, Grzegorz, Lucero, Diego, Neufeld, Edward B., Vaisman, Iosif I., Liotta, Lance, Baranova, Ancha, Remaley, Alan T.

“…ApoB-100 is a member of a large lipid transfer protein superfamily and is one of the main apolipoproteins found on low-density lipoprotein (LDL) and very…”
Get full text

Cell-free, high-density lipoprotein-specific phospholipid efflux assay predicts incident cardiovascular disease by Sato, Masaki, Neufeld, Edward B, Playford, Martin P, Lei, Yu, Sorokin, Alexander V, Aponte, Angel M, Freeman, Lita A, Gordon, Scott M, Dey, Amit K, Jeiran, Kianoush, Hamasaki, Masato, Sampson, Maureen L, Shamburek, Robert D, Tang, Jingrong, Chen, Marcus Y, Kotani, Kazuhiko, Anderson, Josephine Lc, Dullaart, Robin Pf, Mehta, Nehal N, Tietge, Uwe Jf, Remaley, Alan T

“…BACKGROUNDCellular cholesterol efflux capacity (CEC) is a better predictor of cardiovascular disease (CVD) events than HDL-cholesterol (HDL-C) but is not…”
Get full text

Neutrophil-mediated carbamylation promotes articular damage in rheumatoid arthritis by O'Neil, Liam J, Barrera-Vargas, Ana, Sandoval-Heglund, Donavon, Merayo-Chalico, Javier, Aguirre-Aguilar, Eduardo, Aponte, Angel M, Ruiz-Perdomo, Yanira, Gucek, Marjan, El-Gabalawy, Hani, Fox, David A, Katz, James D, Kaplan, Mariana J, Carmona-Rivera, Carmelo

“…Formation of autoantibodies to carbamylated proteins (anti-CarP) is considered detrimental in the prognosis of erosive rheumatoid arthritis (RA). The source of…”
Get full text

Comparison of Omega-3 Eicosapentaenoic Acid Versus Docosahexaenoic Acid-Rich Fish Oil Supplementation on Plasma Lipids and Lipoproteins in Normolipidemic Adults by Yang, Zhi-Hong, Amar, Marcelo, Sampson, Maureen, Courville, Amber B, Sorokin, Alexander V, Gordon, Scott M, Aponte, Angel M, Stagliano, Michael, Playford, Martin P, Fu, Yi-Ping, Yang, Shanna, Mehta, Nehal N, Remaley, Alan T

“…Eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) have both shared and different cardiovascular effects, and commonly used fish oil supplements have…”
Get full text

Regulation of oxidative phosphorylation complex activity: effects of tissue-specific metabolic stress within an allometric series and acute changes in workload by Phillips, Darci, Covian, Raul, Aponte, Angel M, Glancy, Brian, Taylor, Joni F, Chess, David, Balaban, Robert S

“…The concentration of mitochondrial oxidative phosphorylation complexes (MOPCs) is tuned to the maximum energy conversion requirements of a given tissue;…”
Get more information

Sirt1 carboxyl-domain is an ATP-repressible domain that is transferrable to other proteins by Kang, Hyeog, Oka, Shinichi, Lee, Duck-Yeon, Park, Junhong, Aponte, Angel M., Jung, Young-Sang, Bitterman, Jacob, Zhai, Peiyong, He, Yi, Kooshapur, Hamed, Ghirlando, Rodolfo, Tjandra, Nico, Lee, Sean B., Kim, Myung K., Sadoshima, Junichi, Chung, Jay H.

“…Sirt1 is an NAD + -dependent protein deacetylase that regulates many physiological functions, including stress resistance, adipogenesis, cell senescence and…”
Get full text

SIRT3-dependent deacetylation exacerbates acetaminophen hepatotoxicity by Lu, Zhongping, Bourdi, Mohammed, Li, Jian H, Aponte, Angel M, Chen, Yong, Lombard, David B, Gucek, Marjan, Pohl, Lance R, Sack, Michael N

“…Acetaminophen/paracetamol‐induced liver failure—which is induced by the binding of reactive metabolites to mitochondrial proteins and their disruption—is…”
Get full text

Cardioprotection leads to novel changes in the mitochondrial proteome by Wong, Renee, Aponte, Angel M, Steenbergen, Charles, Murphy, Elizabeth

“…It is proposed that ischemic preconditioning (PC) initiates signaling that converges on mitochondria and results in cardioprotection. The outcome of this…”
Get more information

Unfolded protein response and cell death after depletion of brefeldin A-inhibited guanine nucleotide-exchange protein GBF1 by Citterio, Carmen, Vichi, Alessandro, Pacheco-Rodriguez, Gustavo, Aponte, Angel M, Moss, Joel, Vaughan, Martha

“…Guanine nucleotide-exchange factors (GEFs) activate ADP-ribosylation factor (ARF) GTPases that recruit coat proteins to membranes to initiate transport vesicle…”
Get full text

Mitochondrial Matrix Phosphoproteome:  Effect of Extra Mitochondrial Calcium by Hopper, Rachel K, Carroll, Stefanie, Aponte, Angel M, Johnson, D. Thor, French, Stephanie, Shen, Rong-Fong, Witzmann, Frank A, Harris, Robert A, Balaban, Robert S

“…Post-translational modification of mitochondrial proteins by phosphorylation or dephosphorylation plays an essential role in numerous cell signaling pathways…”
Get full text

Association of oxidized ApoB and oxidized ApoA-I with high-risk coronary plaque features in cardiovascular disease by Sorokin, Alexander V., Hong, Christin G., Aponte, Angel M., Florida, Elizabeth M., Tang, Jingrong, Patel, Nidhi, Baranova, Irina N., Li, Haiou, Parel, Philip M., Chen, Vicky, Wilson, Sierra R., Ongstad, Emily L., Collén, Anna, Playford, Martin P., Eggerman, Thomas L., Chen, Marcus Y., Kotani, Kazuhiko, Bocharov, Alexander V., Remaley, Alan T.

“…BACKGROUNDOxidized apolipoprotein B (oxLDL) and oxidized ApoA-I (oxHDL) are proatherogenic. Their prognostic value for assessing high-risk plaques by coronary…”
Get full text

Mice over-expressing the myocardial creatine transporter develop progressive heart failure and show decreased glycolytic capacity by Phillips, Darci, ten Hove, Michiel, Schneider, Jurgen E, Wu, Colin O, Sebag-Montefiore, Liam, Aponte, Angel M, Lygate, Craig A, Wallis, Julie, Clarke, Kieran, Watkins, Hugh, Balaban, Robert S, Neubauer, Stefan

“…Abstract The metabolic phenotype of the failing heart includes a decrease in phosphocreatine and total creatine concentration [Cr], potentially contributing to…”
Get full text

Brefeldin A-inhibited ADP-ribosylation factor activator BIG2 regulates cell migration via integrin β1 cycling and actin remodeling by Shen, Xiaoyan, Li, Chun-Chun, Aponte, Angel M, Shen, Rong-Fong, Billings, Eric M, Moss, Joel, Vaughan, Martha

“…Brefeldin A-inhibited guanine nucleotide-exchange protein (BIG)2 activates ADP-ribosylation factors, ∼20-kDa GTPase proteins critical for continuity of…”
Get full text

Role of a TRIM72 ADP-ribosylation cycle in myocardial injury and membrane repair by Ishiwata-Endo, Hiroko, Kato, Jiro, Tonouchi, Akihiko, Chung, Youn Wook, Sun, Junhui, Stevens, Linda A, Zhu, Jianfeng, Aponte, Angel M, Springer, Danielle A, San, Hong, Takeda, Kazuyo, Yu, Zu-Xi, Hoffmann, Victoria, Murphy, Elizabeth, Moss, Joel

“…Mono-ADP-ribosylation of an (arginine) protein catalyzed by ADP-ribosyltransferase 1 (ART1) - i.e., transfer of ADP-ribose from NAD to arginine - is reversed…”
Get full text

Additive cardioprotection by pharmacological postconditioning with hydrogen sulfide and nitric oxide donors in mouse heart: S-sulfhydration vs. S-nitrosylation by Sun, Junhui, Aponte, Angel M, Menazza, Sara, Gucek, Marjan, Steenbergen, Charles, Murphy, Elizabeth

“…Hydrogen sulfide (H2S), as a gaseous signalling molecule, has been found to play important roles in postconditioning (PostC)-induced cardioprotection. Similar…”
Get full text

Cyclophilin D-mediated regulation of the permeability transition pore is altered in mice lacking the mitochondrial calcium uniporter by Parks, Randi J, Menazza, Sara, Holmström, Kira M, Amanakis, Georgios, Fergusson, Maria, Ma, Hanley, Aponte, Angel M, Bernardi, Paolo, Finkel, Toren, Murphy, Elizabeth

“…Abstract Aims Knockout (KO) of the mitochondrial Ca2+ uniporter (MCU) in mice abrogates mitochondrial Ca2+ uptake and permeability transition pore (PTP)…”
Get full text