Search Results - "Apfel, Athena"

P331: Multiomic approach to diagnosis: A case study in the Undiagnosed Diseases Program by Crowell, Anna, Macnamara, Ellen, Toro, Camilo, Frost, F., Grunseich, Christopher, Apfel, Athena

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Abstract 1187: Optimizing gemcitabine in metastatic TNBC by rational PI3K/AKT combination by Merrill, Nathan M., Vandecan, Nathalie M., Apfel, Athena M., Ulintz, Peter J., Bao, Liwei, Cheng, Xu, Morikawa, Aki, Merajver, Sofia D., Soellner, Matthew B.

“…Metastatic triple-negative breast cancer (TNBC) has a median survival of 13 months, and only 5 months if brain metastases are present. Advances in…”
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Abstract 1194: MEK inhibition in combination with PI3K/AKT/MTOR is a promising therapeutic in basal bladder cancer by Apfel, Athena M., Merrill, Nathan M., Vandecan, Nathalie M., Bao, Liwei, Cheng, Xu, Lopez-Barcons, Lluis A., Day, Kathleen C., Palmbos, Phillip L., Day, Mark L., Udager, Aaron M., Soellner, Matthew B., Merajver, Sofia D.

“…There are diverse resources available for data relevant to the drug screening of bladder cancer cell lines in 2D culture, such as the Cancer Cell Line…”
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Integrative Drug Screening and Multiomic Characterization of Patient-derived Bladder Cancer Organoids Reveal Novel Molecular Correlates of Gemcitabine Response by Merrill, Nathan M., Kaffenberger, Samuel D., Bao, Liwei, Vandecan, Nathalie, Goo, Laura, Apfel, Athena, Cheng, Xu, Qin, Zhaoping, Liu, Chia-Jen, Bankhead, Armand, Wang, Yin, Kathawate, Varun, Tudrick, Lila, Serhan, Habib A., Farah, Zackariah, Ellimoottil, Chad, Hafez, Khaled S., Herrel, Lindsey A., Montgomery, Jeffrey S., Morgan, Todd M., Salami, Simpa S., Weizer, Alon Z., Ulintz, Peter J., Day, Mark L., Soellner, Matthew B., Palmbos, Phillip L., Merajver, Sofia D., Udager, Aaron M.

“…We utilize patient tumor material to generate short-term bladder cancer patient–derived organoid (PDO) cultures for ex vivo drug testing, show that these PDOs…”
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Abstract PO2-16-01: Molecular correlates of drug response to guide therapy in triple-negative breast cancer by Merrill, Nathan, Vandecan, Nathalie, Apfel, Athena, Serhan, Habib, Ulintz, Peter, Bao, Liwei, Cheng, Xu, Morikawa, Aki, Merajver, Sofia, Soellner, Matthew

“…TNBC accounts for 10-20% of total breast cancer cases in the US and is more aggressive, higher grade, and has a poorer prognosis than other forms of breast…”
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Abstract 4012: EGFR inhibition in combination with PI3K/AKT/mTOR and/or Bcl-2 inhibition is a promising novel therapeutic approach for inverted sinonasal papillomas and associated sinonasal carcinomas by Apfel, Athena M., Qin, Zhaoping, Liu, Albert, Soellner, Matthew B., Merajver, Sofia D., Udager, Aaron M., Merrill, Nathan M.

“…Introduction: Activating EGFR mutations are characteristic of inverted sinonasal papillomas (ISP) and ISP-associated sinonasal carcinomas (SNC). Using standard…”
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Abstract A009: Integrative drug screening and multi-omic characterization of patient-derived bladder cancer organoids reveals novel molecular correlates of chemotherapy response by Merrill, Nathan M., Kaffenberger, Samuel D., Bao, Liwei, Vandecan, Nathalie, Goo, Laura E., Apfel, Athena, Cheng, Xu, Qin, Zhaoping, Liu, Chia-Jen, Bankhead, Armand, Wang, Yin, Kathawate, Varun, Tudrick, Lila, Serhan, Habib, Farah, Zackariah, Ellimoottil, Chad, Hafez, Khaled S., Herrel, Lindsey A., Montgomery, Jeffrey S., Morgan, Todd M., Salami, Simpa S., Weizer, Alon Z., Ulintz, Peter J., Day, Mark L., Soellner, Matthew B., Palmbos, Phillip L., Merajver, Sofia D., Udager, Aaron M.

“…Introduction: Predicting response to therapy for each patient’s tumor is critical to improving long-term outcomes for muscle-invasive bladder cancer (MIBC)…”
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Abstract 3072: Functional assays of drug sensitivity in real-time from patient material for precision oncology in bladder cancer by Merrill, Nathan M., Bao, Liwei, Cheng, Xu, Vandecan, Nathalie, Qin, Zhaoping, Liu, Albert, Apfel, Athena, Goo, Laura, Tudrick, Lila, Bankhead, Armand, Palmbos, Phil, Kaffenberger, Samuel, Hafez, Khaled, Montgomery, Jeffrey, Morgan, Todd, Alva, Ajjai, Udager, Aaron, Soellner, Matthew, Merajver, Sofia

“…Introduction: Bladder cancer (BC) is the most frequent urinary system cancer in the US. Neoadjuvant chemotherapy before cystectomy for muscle-invasive BC is…”
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Optimizing Precision Medicine for Breast Cancer Brain Metastases with Functional Drug Response Assessment by Morikawa, Aki, Li, Jinju, Ulintz, Peter, Cheng, Xu, Apfel, Athena, Robinson, Dan, Hopkins, Alex, Kumar-Sinha, Chandan, Wu, Yi-Mi, Serhan, Habib, Verbal, Kait, Thomas, Dafydd, Hayes, Daniel F, Chinnaiyan, Arul M, Baladandayuthapani, Veerabhadran, Heth, Jason, Soellner, Matthew B, Merajver, Sofia D, Merrill, Nathan

“…The development of novel therapies for brain metastases is an unmet need. Brain metastases may have unique molecular features that could be explored as…”
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