Search Results - "Aparna, Jayasekharan S."

Regulatory role of SphK1 in TLR7/9‐dependent type I interferon response and autoimmunity by Mohammed, Sabira, Vineetha, Nalanda S., James, Shirley, Aparna, Jayasekharan S., Babu Lankadasari, Manendra, Maeda, Takahiro, Ghosh, Abhirupa, Saha, Sudipto, Li, Quan‐Zhen, Spiegel, Sarah, Harikumar, Kuzhuvelil B.

“…Plasmacytoid dendritic cells (pDCs) express Toll like receptors (TLRs) that modulate the immune response by production of type I interferons. Here, we report…”
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Targeting acid ceramidase enhances antitumor immune response in colorectal cancer by Vijayan, Yadu, James, Shirley, Viswanathan, Arun, Aparna, Jayasekharan S, Bindu, Anu, Namitha, Narayanan N, Anantharaman, Devasena, Babu Lankadasari, Manendra, Harikumar, Kuzhuvelil B

“…[Display omitted] •Acid ceramidase (ASAH1) is an enzyme in sphingolipid metabolism that converts pro-survival ceramide into sphingosine and its role in…”
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Cardamonin Attenuates Experimental Colitis and Associated Colorectal Cancer by James, Shirley, Aparna, Jayasekharan S, Babu, Anu, Paul, Aswathy Mary, Lankadasari, Manendra Babu, Athira, Subha R, Kumar, Sreesha S, Vijayan, Yadu, Namitha, Narayanan N, Mohammed, Sabira, Reshmi, Girijadevi, Harikumar, Kuzhuvelil B

“…Cardamonin is a naturally occurring chalcone, majorly from the Zingiberaceae family, which includes a wide range of spices from India. Herein, we investigated…”
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Targeting S1PR1/STAT3 loop abrogates desmoplasia and chemosensitizes pancreatic cancer to gemcitabine by Lankadasari, Manendra Babu, Aparna, Jayasekharan S, Mohammed, Sabira, James, Shirley, Aoki, Kazunori, Binu, Valsalakumari S, Nair, Sindhu, Harikumar, Kuzhuvelil B

“…Pancreatic cancer is associated with poor prognosis with a 5-year survival rate of less than 6%. Approximately 90% of pancreatic cancer patients harbor somatic…”
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Examination of the role of sphingosine kinase 2 in a murine model of systemic lupus erythematosus by Mohammed, Sabira, Vineetha, Nalanda S., James, Shirley, Aparna, Jayasekharan S., Lankadasari, Manendra Babu, Allegood, Jeremy C., Li, Quan-Zhen, Spiegel, Sarah, Harikumar, Kuzhuvelil B.

“…ABSTRACT Systemic lupus erythematosus is an autoimmune disease characterized by overproduction of type 1 IFN that causes multiple organ dysfunctions…”
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Cardamonin inhibits colonic neoplasia through modulation of MicroRNA expression by James, Shirley, Aparna, Jayasekharan S., Paul, Aswathy Mary, Lankadasari, Manendra Babu, Mohammed, Sabira, Binu, Valsalakumari S., Santhoshkumar, Thankayyan R., Reshmi, Girijadevi, Harikumar, Kuzhuvelil B.

“…Colorectal cancer is currently the third leading cause of cancer related deaths. There is considerable interest in using dietary intervention strategies to…”
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Abrogation of Pancreatic Cancer Using a Brain Malady Drug by Lankadasari, Manendra Babu, Jayasekharan, Aparna S, Mohammed, Sabira, James, Shirley, Aoki, Kazunori, Binu, Valasalakumari S, Nair, Sindhu, Harikumar, Kuzhuvelil B

“…Pancreatic cancer is the fourth preeminent cause of cancer‐related deaths with a poor prognosis. Desmoplasia and drug resistance are few of the pivotal hurdles…”
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