Synthesis and Antiviral Evaluation of Some C3-Symmetrical Trialkoxy-Substituted 1,3,5-Triazines and Their Molecular Geometry

As one of our projects, we here report some new molecular modifications of 2,4,6-trichloro-1,3,5-triazine (TCTAZ: 1) to symmetrical 2,4,6-trialkoxy- or 2,4,6-triaryloxy-substituted 1,3,5-triazine (TAZ) molecules, as well as the results of anti-herpes simplex virus type 1 (anti-HSV-1) activity evalua...

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Bibliographic Details
Published in:	Chemical and Pharmaceutical Bulletin Vol. 63; no. 11; pp. 935 - 944
Main Authors:	Nobuko Mibua, Kazumi Yokomizob, Hatsumi Akia, Norimasa Otaa, Hiroyuki Fujiia, Ai Yuzurihaa, Shiori Saneyoshib, Aoi Tanakab, Airi Kogaa, Jianrong Zhoub, Takeshi Miyatab, Kunihiro Sumotoa
Format:	Journal Article
Language:	Japanese
Published:	Pharmaceutical Society of Japan 01-11-2015
Online Access:	Get full text
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Summary:	As one of our projects, we here report some new molecular modifications of 2,4,6-trichloro-1,3,5-triazine (TCTAZ: 1) to symmetrical 2,4,6-trialkoxy- or 2,4,6-triaryloxy-substituted 1,3,5-triazine (TAZ) molecules, as well as the results of anti-herpes simplex virus type 1 (anti-HSV-1) activity evaluation of synthesized 2,4,6-trisubstituted TAZ derivatives. Among the tested 2,4,6-trisubstituted TAZ derivatives, we reconfirmed that a C3-symmetrical TAZ derivative, 4e, shows the highest level of anti-HSV-1 activity with a good selectivity index. In this paper, we also report the results of the preparation of newly targeted TAZ derivatives and the structure-activity relationships (SARs) of these trialkoxy-substituted TAZ derivatives and related compounds. The sugar recognition properties of C3-symmetrical TAZ derivative 4e are also described.
ISSN:	0009-2363