Search Results - "Anzano, Mario A."

Mice Lacking Smad3 Are Protected Against Cutaneous Injury Induced by Ionizing Radiation by Flanders, Kathleen C., Sullivan, Catherine D., Fujii, Makiko, Sowers, Anastasia, Anzano, Mario A., Arabshahi, Alidad, Major, Christopher, Deng, Chuxia, Russo, Angelo, Mitchell, James B., Roberts, Anita B.

“…Transforming growth factor-β (TGF-β) plays a central role in the pathogenesis of inflammatory and fibrotic diseases, including radiation-induced fibrosis. We…”
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Role of Smad3 in the hormonal modulation of in vivo wound healing responses by Ashcroft, Gillian S., Mills, Stuart J., Flanders, Kathleen C., Lyakh, Lyudmila A., Anzano, Mario A., Gilliver, Stephen C., Roberts, Anita B.

“…Smad3 is involved in mediating intracellular signaling by members of the transforming growth factor‐β superfamily and plays a critical role in the cellular…”
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Interference with Transforming Growth Factor-β/ Smad3 Signaling Results in Accelerated Healing of Wounds in Previously Irradiated Skin by Flanders, Kathleen C., Major, Christopher D., Arabshahi, Alidad, Aburime, Ekinadese E., Okada, Miya H., Fujii, Makiko, Blalock, Timothy D., Schultz, Gregory S., Sowers, Anastasia, Anzano, Mario A., Mitchell, James B., Russo, Angelo, Roberts, Anita B.

“…Transforming growth factor (TGF)-β regulates many aspects of wound repair including inflammation, chemotaxis, and deposition of extracellular matrix. We…”
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Purification and properties of a type .beta. transforming growth factor from bovine kidney by Roberts, Anita B, Anzano, Mario A, Meyers, Chester A, Wideman, Januz, Blacher, Russell, Pan, Yu Ching E, Stein, Stanley, Lehrman, S. Russ, Smith, Joseph M

“…Type beta transforming growth factor (TGF-beta) has been purified 200 000-fold from bovine kidneys. This peptide is characterized by its ability to induce…”
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Prevention of breast cancer in the rat with 9-cis-retinoic acid as a single agent and in combination with Tamoxifen by ANZANO, M. A, BYERS, S. W, SMITH, J. M, PEER, C. W, MULLEN, L. T, BROWN, C. C, ROBERTS, A. B, SPORN, M. B

“…We show that 9-cis-retinoic acid (9cRA) is a potent inhibitor of mammary carcinogenesis induced by N-nitroso-N-methylurea in Sprague-Dawley rats. Rats were…”
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Chemoprevention of Mammary Carcinogenesis in the Rat: Combined Use of Raloxifene and 9-cis-Retinoic Acid by Anzano, Mario A., Peer, Christopher W., Smith, Joseph M., Mullen, Larry T., Shrader, Mark W., Logsdon, Daniel L., Driver, Craig L., Brown, Charles C., Roberts, Anita B., Sporn, Michael B.

“…The combination of 9-cis-retinoic acid (9cRA) and raloxifene was evaluated for its chemopreventive activity in the well-accepted rat model of breast cancer…”
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Conditional knockout of the Smad1 gene by Huang, Shixia, Tang, Binwu, Usoskin, Dmitry, Lechleider, Robert J., Jamin, Soazik P., Li, Cuiling, Anzano, Mario A., Ebendal, Ted, Deng, Chuxia, Roberts, Anita B.

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Chemopreventive activity of tamoxifen, N-(4-hydroxyphenyl)retinamide, and the vitamin D analogue Ro24-5531 for androgen-promoted carcinomas of the rat seminal vesicle and prostate by LUCIA, M. S, ANZANO, M. A, ROBERTS, A. B, SPORN, M. B, SLAYTER, M. V, ANVER, M. R, GREEN, D. M, SHRADER, M. W, LOGSDON, D. L, DRIVER, C. L, BROWN, C. C, PEER, C. W

“…We evaluated the ability of dietary N-(4-hydroxyphenyl)retinamide; 1 alpha,25-dihydroxy-16-ene-23-yne-26,27-hexafluorocholecalcifero l (Ro24-5531); and…”
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Growth factor production by human colon carcinoma cell lines by ANZANO, M. A, RIEMAN, D, PRICHETT, W, BOWEN-POPE, D. F, GREIG, R

“…Conditioned media collected under serum-free conditions over 24 to 48 h from 18 human colon adenocarcinoma cell lines were analyzed for transforming growth…”
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Antagonistic actions of retinoic acid and dexamethasone on anchorage-independent growth and epidermal growth factor binding of normal rat kidney cells by ROBERTS, A. B, ANZANO, M. A, LAMB, L. C, SMITH, J. M, SPORN, M. B

“…Type beta transforming growth factor (TGF-beta), in combination with epidermal growth factor (EGF) can induce nonneoplastic normal rat kidney cells to express…”
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Growth, appetite, sequence of pathological signs and survival following the induction of rapid, synchronous vitamin A deficiency in the rat by Anzano, M A, Lamb, A J, Olson, J A

“…Experiments were conducted to determine the sequence and reliability of appearance of key signs of vitamin A deficiency. Rapid and essentially synchronous…”
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Development and characterization of nontumorigenic and tumorigenic epithelial cell lines from rat dorsal-lateral prostate by Danielpour, D, Kadomatsu, K, Anzano, M A, Smith, J M, Sporn, M B

“…We have established two new epithelial cell lines (NRP-152, NRP-154), with markedly different properties, from the dorsal-lateral prostate of Lobund/Wistar…”
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Type β Transforming Growth Factor: A Bifunctional Regulator of Cellular Growth by Roberts, Anita B., Anzano, Mario A., Wakefield, Lalage M., Roche, Nanette S., Stern, David F., Sporn, Michael B.

“…Type β transforming growth factor (TGF-β ) is a two-chain polypeptide of 25,000 daltons isolated from many tissues, including bovine kidney, human placenta,…”
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New Class of Transforming Growth Factors Potentiated by Epidermal Growth Factor: Isolation from Non-Neoplastic Tissues by Roberts, Anita B., Anzano, Mario A., Lamb, Lois C., Smith, Joseph M., Sporn, Michael B.

“…Proteins potentiated by epidermal growth factor (EGF) to induce a transformed phenotype in non-neoplastic rat kidney fibroblasts in cell culture have been…”
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Sarcoma Growth Factor from Conditioned Medium of Virally Transformed Cells is Composed of Both Type α and Type β Transforming Growth Factors by Anzano, Mario A., Roberts, Anita B., Smith, Joseph M., Sporn, Michael B., De Larco, Joseph E.

“…Sarcoma growth factor (SGF) derived from conditioned medium of Moloney sarcoma virus-transformed cells and partially purified by gel filtration (crude SGF) has…”
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Histogenesis of induced prostate and seminal vesicle carcinoma in Lobund-Wistar rats : a system for histological scoring and grading by SLAYTER, M. V, ANZANO, M. A, KADOMATSU, K, SMITH, J. M, SPORN, M. B

“…We have developed a grading system for the evaluation of the histogenesis of neoplastic lesions of the prostate and seminal vesicle of the laboratory rat…”
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The Genes Encoding Geranylgeranyl Transferase α-Subunit and Transglutaminase 1 Are Very Closely Linked but Not Functionally Related in Terminally Differentiating Keratinocytes by Song, Hae-Jun, Rossi, Antonello, Ceci, Roberta, Kim, In-Gyu, Anzano, Mario A., Jang, Shyh-Ing, De Laurenzi, Vincenzo, Steinert, Peter M.

“…We report here the entire exon/intron structure of the gene encoding the α-subunit of human Rab geranylgeranyl transferase (RABGGTA) gene, which is positioned…”
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Synergistic interaction of two classes of transforming growth factors from murine sarcoma cells by Anzano, M A, Roberts, A B, Meyers, C A, Komoriya, A, Lamb, L C, Smith, J M, Sporn, M B

“…Transforming growth factors (TGFs) isolated from murine sarcoma virus-transformed 3T3 cells have been separated by high-pressure liquid chromatography into two…”
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Expression of sulfated glycoprotein 2 is associated with carcinogenesis induced by N-nitroso-N-methylurea in rat prostate and seminal vesicle by KADOMATSU, K, ANZANO, M. A, SLAYTER, M. V, WINOKUR, T. S, SMITH, J. M, SPORN, M. B

“…To understand the molecular mechanism of carcinogenesis in androgen-dependent tumors, we have searched for new markers which are associated with this process…”
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Anchorage-independent growth of primary rat embryo cells is induced by platelet-derived growth factor and inhibited by type-beta transforming growth factor by Anzano, M A, Roberts, A B, Sporn, M B

“…Several growth factors implicated in the process of cellular transformation were tested for their ability to induce anchorage-independent (AI) growth of…”
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