Search Results - "Anzali, Soheila"

The multifunctional role of ectoine as a natural cell protectant by Graf, Ruediger, PhD, Anzali, Soheila, PhD, Buenger, Joachim, PhD, Pfluecker, Frank, PhD, Driller, Hansjuergen, PhD

“…Abstract The protective properties of ectoine, formerly described for only extremophilic microorganisms, can be transferred to human skin. Our present data…”
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Halothiophene benzimidazoles as P1 surrogates of inhibitors of blood coagulation factor Xa by MEDERSKI, Werner W. K. R, DORSCH, Dieter, ANZALI, Soheila, GLEITZ, Johannes, CEZANNE, Bertram, TSAKLAKIDIS, Christos

“…Neutral weak halothiophene benzimidazole inhibitors of the serine protease factor Xa were identified via screening of a compound library. The X-ray crystal…”
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Discriminating between Drugs and Nondrugs by Prediction of Activity Spectra for Substances (PASS) by Anzali, Soheila, Barnickel, Gerhard, Cezanne, Bertram, Krug, Michael, Filimonov, Dmitrii, Poroikov, Vladimir

“…Using the computer system PASS (prediction of activity spectra for substances), which predicts simultaneously several hundreds of biological activities, a…”
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The comparison of geometric and electronic properties of molecular surfaces by neural networks: application to the analysis of corticosteroid-binding globulin activity of steroids by Anzali, S, Barnickel, G, Krug, M, Sadowski, J, Wagener, M, Gasteiger, J, Polanski, J

“…It is shown how a self-organizing neural network such as the one introduced by Kohonen can be used to analyze features of molecular surfaces, such as shape and…”
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1. Endothelin antagonists: Search for surrogates of methylendioxyphenyl by means of a kohonen neural network by Anzali, Soheila, Mederski, Werner W.K.R, Osswald, Mathias, Dorsch, Dieter

“…The methylendioxyphenyl group, present in a number of potent endothelin receptor antagonists, could have undesirable metabolic interactions with cytochrome…”
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Bioisosterism of Fluorine and Cyano as Indole Substituents. Theoretical, in vitro and in vivo Examination by Timo Heinrich, Henning Böttcher, Gerd D. Bartoszyk, Harry Schwartz, Soheila Anzali, Joachim März, Hartmut E. Greiner, Christoph A. Seyfried

“…Fluorine substitution modifies structural attributes and often induces unexpected effects. When substituting fluorine with cyano in position 5 of the indole in…”
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The discovery and optimization of hexahydro-2H-pyrano[3,2-c]quinolines (HHPQs) as potent and selective inhibitors of the mitotic kinesin-5 by SCHIEMANN, Kai, FINSINGER, Dirk, ZENKE, Frank, AMENDT, Christiane, KNÖCHEL, Thorsten, BRUGE, David, BUCHSTALLER, Hans-Peter, EMDE, Ulrich, STÄHLE, Wolfgang, ANZALI, Soheila

“…Here we describe the discovery and optimization of hexahydro-2H-pyrano[3,2-c]quinolines (HHPQs) as potent and selective inhibitors of the mitotic kinesin-5…”
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Synthesis and Structure−Activity Relationship in a Class of Indolebutylpiperazines as Dual 5-HT1A Receptor Agonists and Serotonin Reuptake Inhibitors by Heinrich, Timo, Böttcher, Henning, Gericke, Rolf, Bartoszyk, Gerd D, Anzali, Soheila, Seyfried, Christoph A, Greiner, Hartmut E, van Amsterdam, Christoph

“…Systematic structural modifications of indolealkylphenylpiperazines led to improved selectivity and affinity within this class of 5-HT1A receptor agonists…”
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The multifunctional role of ectoine as a natural cell protectant: Cosmeceuticals: Part I by GRAF, Ruediger, ANZALI, Soheila, BUENGER, Joachim, PFLUECKER, Frank, DRILLER, Hansjuergen

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Linear and nonlinear functions on modeling of aqueous solubility of organic compounds by two structure representation methods by Yan, Aixia, Gasteiger, Johann, Krug, Michael, Anzali, Soheila

“…Several quantitative models for the prediction of aqueous solubility of organic compounds were developed based on a diverse dataset with 2084 compounds by…”
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The discovery and optimization of hexahydro-2 H-pyrano[3,2- c]quinolines (HHPQs) as potent and selective inhibitors of the mitotic kinesin-5 by Schiemann, Kai, Finsinger, Dirk, Zenke, Frank, Amendt, Christiane, Knöchel, Thorsten, Bruge, David, Buchstaller, Hans-Peter, Emde, Ulrich, Stähle, Wolfgang, Anzali, Soheila

“…The synthesis, SAR, co-crystal structure and in vivo activity of hexahydro-2 H-pyrano[3,2- c]quinolines (HHPQs) as potent and selective inhibitors of the…”
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Synthesis and structure--activity relationship in a class of indolebutylpiperazines as dual 5-HT(1A) receptor agonists and serotonin reuptake inhibitors by Heinrich, Timo, Böttcher, Henning, Gericke, Rolf, Bartoszyk, Gerd D, Anzali, Soheila, Seyfried, Christoph A, Greiner, Hartmut E, Van Amsterdam, Christoph

“…Systematic structural modifications of indolealkylphenylpiperazines led to improved selectivity and affinity within this class of 5-HT(1A) receptor agonists…”
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Synthesis and Structure−Activity Relationship in a Class of Indolebutylpiperazines as Dual 5-HT 1A Receptor Agonists and Serotonin Reuptake Inhibitors by Heinrich, Timo, Böttcher, Henning, Gericke, Rolf, Bartoszyk, Gerd D., Anzali, Soheila, Seyfried, Christoph A., Greiner, Hartmut E., van Amsterdam, Christoph

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3. Endothelin antagonists: discovery of EMD 122946, a highly potent and orally active ET A selective antagonist by Mederski, Werner W.K.R., Dorsch, Dieter, Osswald, Mathias, Anzali, Soheila, Christadler, Maria, Schmitges, Claus-Jochen, Schelling, Pierre, Wilm, Claudia, Fluck, Markus

“…The discovery, in vitro and in vivo studies of the highly potent ET A antagonist EMD 122946 are presented. This compound displayed high binding affinity and…”
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2. Endothelin antagonists : Evaluation of 2,1,3-benzothiadiazole as a methylendioxyphenyl bioisoster by MEDERSKI, W. W. K. R, OSSWALD, M, DORSCH, D, ANZALI, S, CHRISTADLER, M, SCHMITGES, C.-J, WILM, C

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2.Endothelin antagonists: Evaluation of 2,1,3-benzothiadiazole as a methylendioxyphenyl bioisoster by Mederski, Werner W.K.R, Osswald, Mathias, Dorsch, Dieter, Anzali, Soheila, Christadler, Maria, Schmitges, Claus-Jochen, Wilm, Claudia

“…The methylendioxyphenyl group is present in a number of endothelin receptor antagonists thus far reported. By means of a Kohonen neural network we discovered…”
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3. endothelin antagonists : Discovery of EMD 122946, a highly potent and orally active ETA selective antagonist by MEDERSKI, W. W. K. R, DORSCH, D, OSSWALD, M, ANZALI, S, CHRISTADLER, M, SCHMITGES, C.-J, SCHELLING, P, WILM, C, FLUCK, M

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Discriminating between drugs and nondrugs by prediction of activity spectra for substances (PASS) by ANZALI, Soheila, BARNICKEL, Gerhard, CEZANNE, Bertram, KRUG, Michael, FILIMONOV, Dmitrii, POROIKOV, Vladimir

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