Search Results - "Anyona, Samuel B"
-
1
Entire expressed peripheral blood transcriptome in pediatric severe malarial anemia
Published in Nature communications (12-06-2024)“…This study on severe malarial anemia (SMA: Hb < 6.0 g/dL), a leading global cause of childhood morbidity and mortality, compares the entire expressed whole…”
Get full text
Journal Article -
2
Hemoglobinopathies, merozoite surface protein-2 gene polymorphisms, and acquisition of Epstein Barr virus among infants in Western Kenya
Published in BMC cancer (20-06-2023)“…Epstein Barr virus (EBV)-associated endemic Burkitt's Lymphoma pediatric cancer is associated with morbidity and mortality among children resident in…”
Get full text
Journal Article -
3
Human NCR3 gene variants rs2736191 and rs11575837 alter longitudinal risk for development of pediatric malaria episodes and severe malarial anemia
Published in BMC genomics (13-09-2023)“…Plasmodium falciparum malaria is a leading cause of pediatric morbidity and mortality in holoendemic transmission areas. Severe malarial anemia [SMA,…”
Get full text
Journal Article -
4
Changes in the frequencies of Plasmodium falciparum dhps and dhfr drug-resistant mutations in children from Western Kenya from 2005 to 2018: the rise of Pfdhps S436H
Published in Malaria journal (22-10-2020)“…Sulfadoxine-pyrimethamine (SP) is the only anti-malarial drug formulation approved for intermittent preventive treatment in pregnancy (IPTp). However,…”
Get full text
Journal Article -
5
Cyclooxygenase-2 haplotypes influence the longitudinal risk of malaria and severe malarial anemia in Kenyan children from a holoendemic transmission region
Published in Journal of human genetics (01-01-2020)“…Cyclooxygenase-2 [(COX-2) or prostaglandin endoperoxide H2 synthase-2 (PTGS-2)] induces the production of prostaglandins as part of the host-immune response to…”
Get full text
Journal Article -
6
Differential Gene Expression in Host Ubiquitination Processes in Childhood Malarial Anemia
Published in Frontiers in genetics (22-11-2021)“…Malaria remains one of the leading global causes of childhood morbidity and mortality. In holoendemic transmission regions, such as western Kenya, severe…”
Get full text
Journal Article -
7
Association between Fcγ receptor IIA, IIIA and IIIB genetic polymorphisms and susceptibility to severe malaria anemia in children in western Kenya
Published in BMC infectious diseases (20-04-2017)“…Naturally-acquired immunity to Plasmodium falciparum malaria develops after several episodes of infection. Fc gamma receptors (FcγRs) bind to immunoglobulin G…”
Get full text
Journal Article -
8
Nonsynonymous amino acid changes in the α-chain of complement component 5 influence longitudinal susceptibility to Plasmodium falciparum infections and severe malarial anemia in kenyan children
Published in Frontiers in genetics (14-09-2022)“…Severe malarial anemia (SMA; Hb < 5.0 g/dl) is a leading cause of childhood morbidity and mortality in holoendemic transmission regions such as western Kenya…”
Get full text
Journal Article -
9
Genetic variation in CSF2 (5q31.1) is associated with longitudinal susceptibility to pediatric malaria, severe malarial anemia, and all-cause mortality in a high-burden malaria and HIV region of Kenya
Published in Tropical medicine and health (25-06-2022)“…Plasmodium falciparum infections remain among the leading causes of morbidity and mortality in holoendemic transmission areas. Located within region 5q31.1,…”
Get full text
Journal Article -
10
Transcriptomic and Proteomic Insights into Host Immune Responses in Pediatric Severe Malarial Anemia: Dysregulation in HSP60-70-TLR2/4 Signaling and Altered Glutamine Metabolism
Published in Pathogens (Basel) (03-10-2024)“…Severe malarial anemia (SMA, Hb < 6.0 g/dL) is a leading cause of childhood morbidity and mortality in holoendemic transmission zones. This study explored the…”
Get full text
Journal Article -
11
Genetic variation in interleukin-7 is associated with a reduced erythropoietic response in Kenyan children infected with Plasmodium falciparum
Published in BMC medical genetics (16-08-2019)“…Severe malarial anemia (SMA) is a leading cause of malaria-related morbidity and mortality in children. The genetic factors that influence development of SMA…”
Get full text
Journal Article -
12
Ingestion of hemozoin by peripheral blood mononuclear cells alters temporal gene expression of ubiquitination processes
Published in Biochemistry and biophysics reports (01-03-2022)“…Plasmodium falciparum (Pf) malaria is among the leading causes of childhood morbidity and mortality worldwide. During a natural infection, ingestion of the…”
Get full text
Journal Article -
13
Factors associated with non-adherence to Artemisinin-based combination therapy (ACT) to malaria in a rural population from holoendemic region of western Kenya
Published in BMC infectious diseases (24-06-2012)“…Over the years, reports implicate improper anti-malarial use as a major contributor of morbidity and mortality amongst millions of residents in malaria endemic…”
Get full text
Journal Article -
14
Impact of RTS,S/AS02(A) and RTS,S/AS01(B) on genotypes of P. falciparum in adults participating in a malaria vaccine clinical trial
Published in PloS one (17-11-2009)“…RTS,S, a candidate vaccine for malaria, is a recombinant protein expressed in yeast containing part of the circumsporozoite protein (CSP) sequence of 3D7…”
Get full text
Journal Article -
15
A Comprehensive COVID-19 Daily News and Medical Literature Briefing to Inform Health Care and Policy in New Mexico: Implementation Study
Published in JMIR medical education (23-02-2022)“…On March 11, 2020, the New Mexico Governor declared a public health emergency in response to the COVID-19 pandemic. The New Mexico medical advisory team…”
Get full text
Journal Article -
16
Functional Promoter Haplotypes of Interleukin-18 Condition Susceptibility to Severe Malarial Anemia and Childhood Mortality
Published in Infection and Immunity (01-12-2011)“…Classifications Services IAI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
Get full text
Journal Article -
17
Functional haplotypes of Fc gamma (Fcγ) receptor (FcγRIIA and FcγRIIIB) predict risk to repeated episodes of severe malarial anemia and mortality in Kenyan children
Published in Human genetics (01-02-2012)“…Development of protective immunity against Plasmodium falciparum is partially mediated through binding of malaria-specific IgG to Fc gamma (γ) receptors…”
Get full text
Journal Article -
18
Complement component 3 mutations alter the longitudinal risk of pediatric malaria and severe malarial anemia
Published in Experimental biology and medicine (Maywood, N.J.) (01-04-2022)“…Severe malarial anemia (SMA) is a leading cause of childhood morbidity and mortality in holoendemic Plasmodium falciparum transmission regions. To gain…”
Get full text
Journal Article -
19
Direct detection of bacteremia by exploiting host-pathogen interactions of lipoteichoic acid and lipopolysaccharide
Published in Scientific reports (17-04-2019)“…Bacteremia is a leading cause of death in sub-Saharan Africa where childhood mortality rates are the highest in the world. The early diagnosis of bacteremia…”
Get full text
Journal Article -
20
Pitting of malaria parasites and spherocyte formation
Published in Malaria journal (31-07-2006)“…A high prevalence of spherocytes was detected in blood smears of children enrolled in a case control study conducted in the malaria holoendemic Lake Victoria…”
Get full text
Journal Article