Search Results - "Anway, Matthew D"

Endocrine Disruptor Vinclozolin Induced Epigenetic Transgenerational Adult-Onset Disease by Anway, Matthew D, Leathers, Charles, Skinner, Michael K

“…The fetal basis of adult disease is poorly understood on a molecular level and cannot be solely attributed to genetic mutations or a single etiology. Embryonic…”
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Epigenetic transgenerational inheritance of vinclozolin induced mouse adult onset disease and associated sperm epigenome biomarkers by Guerrero-Bosagna, Carlos, Covert, Trevor R., Haque, Md. M., Settles, Matthew, Nilsson, Eric E., Anway, Matthew D., Skinner, Michael K.

“…[Display omitted] ► Demonstrates ability of vinclozolin to induce epigenetic transgenerational inheritance of reproductive disease in the outbred mouse model,…”
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Transgenerational epigenetic programming of the brain transcriptome and anxiety behavior by Skinner, Michael K, Anway, Matthew D, Savenkova, Marina I, Gore, Andrea C, Crews, David

“…Embryonic exposure to the endocrine disruptor vinclozolin during gonadal sex determination promotes an epigenetic reprogramming of the male germ-line that is…”
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Transgenerational epigenetic imprints on mate preference by Crews, David, Gore, Andrea C, Hsu, Timothy S, Dangleben, Nygerma L, Spinetta, Michael, Schallert, Timothy, Anway, Matthew D, Skinner, Michael K

“…Environmental contamination by endocrine-disrupting chemicals (EDC) can have epigenetic effects (by DNA methylation) on the germ line and promote disease…”
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Epigenetic programming of the germ line: effects of endocrine disruptors on the development of transgenerational disease by Anway, Matthew D, Skinner, Michael K

“…Abstract Epigenetic programming of the germ line occurs during embryonic development in a sex-specific manner. The male germ line becomes imprinted following…”
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Transgenerational effects of the endocrine disruptor vinclozolin on the prostate transcriptome and adult onset disease by Anway, Matthew D., Skinner, Michael K.

“…PURPOSE The ability of an endocrine disruptor exposure during gonadal sex determination to promote a transgenerational prostate disease phenotype was…”
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Transgenerational epigenetic effects of the endocrine disruptor vinclozolin on pregnancies and female adult onset disease by Nilsson, Eric E, Anway, Matthew D, Stanfield, Jacob, Skinner, Michael K

“…Endocrine disruptor exposure during gonadal sex determination was previously found to induce male rat adult onset transgenerational disease (F1–F4 generation),…”
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Transforming growth factor beta (TGFβ1, TGFβ2 and TGFβ3) null-mutant phenotypes in embryonic gonadal development by Memon, Mushtaq A., Anway, Matthew D., Covert, Trevor R., Uzumcu, Mehmet, Skinner, Michael K.

“…The role transforming growth factor beta (TGFb) isoforms TGFb1, TGFb2 and TGFb3 have in the regulation of embryonic gonadal development was investigated with…”
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Seminiferous Cord Formation and Germ-Cell Programming: Epigenetic Transgenerational Actions of Endocrine Disruptors by SKINNER, MICHAEL K., ANWAY, MATTHEW D.

“…: The molecular and cellular control of embryonic testis development was investigated through an analysis of the embryonic testis transcriptome to identify…”
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Isolation of Sertoli Cells from Adult Rat Testes: An Approach to Ex Vivo Studies of Sertoli Cell Function by ANWAY, Matthew D, FOLMER, Janet, WRIGHT, William W, ZIRKIN, Barry R

“…Much of what is known about the molecular regulation and function of adult Sertoli cells has been inferred from in vitro studies of immature Sertoli cells…”
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Epigenetic Transgenerational Actions of Endocrine Disruptors by Anway, Matthew D, Skinner, Michael K

“…Endocrine disruptors have recently been shown to promote an epigenetic transgenerational phenotype involving a number of disease states (e.g. male…”
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Regulation of the gonadal transcriptome during sex determination and testis morphogenesis: comparative candidate genes by Clement, Tracy M, Anway, Matthew D, Uzumcu, Mehmet, Skinner, Michael K

“…Gene expression profiles during sex determination and gonadal differentiation were investigated to identify new potential regulatory factors. Embryonic day 13…”
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Epigenetic transgenerational actions of vinclozolin on the development of disease and cancer by Skinner, Michael K, Anway, Matthew D

“…Exposure to an environmental endocrine disruptor (e.g., vinclozolin) during embryonic gonadal sex determination appears to alter the male germ line epigenome…”
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Intratesticular Androgen Levels, Androgen Receptor Localization, and Androgen Receptor Expression in Adult Rat Sertoli Cells by HILL, Christine M, ANWAY, Matthew D, ZIRKIN, Barry R, BROWN, Terry R

“…In the rat, quantitatively normal spermatogenesis is maintained only when intratesticular testosterone (ITT) levels greatly exceed the peripheral T…”
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Reduced Intratesticular Testosterone Concentration Alters the Polymerization State of the Sertoli Cell Intermediate Filament Cytoskeleton by Degradation of Vimentin by Show, Matthew D, Anway, Matthew D, Folmer, Janet S, Zirkin, Barry R

“…The Sertoli cell intermediate filament cytoskeleton is composed of the type III family member vimentin. The distribution of Sertoli cell vimentin varies with…”
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Transgenerational epigenetic programming of the embryonic testis transcriptome by Anway, Matthew D., Rekow, Stephen S., Skinner, Michael K.

“…Embryonic exposure to the endocrine disruptor vinclozolin during gonadal sex determination appears to promote an epigenetic reprogramming of the male germ line…”
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Transgenerational Epigenetic Imprinting of the Male Germline by Endocrine Disruptor Exposure during Gonadal Sex Determination by Chang, Hung-Shu, Anway, Matthew D, Rekow, Stephen S, Skinner, Michael K

“…Embryonic exposure to the endocrine disruptor vinclozolin at the time of gonadal sex determination was previously found to promote transgenerational disease…”
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Expression and Localization of Cathepsin K In Adult Rat Sertoli Cells by ANWAY, Matthew D, WRIGHT, William W, ZIRKIN, Barry R, KORAH, Nadine, MORT, John S, HERMO, Louis

“…The cathepsins are a family of cysteine proteases that have been broadly implicated in proteolytic processes during cell growth, cell development, and normal…”
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Testicular Expression and Distribution of the Rat Bcl2 Modifying Factor in Response to Reduced Intratesticular Testosterone by SHOW, Matthew D, FOLMER, Janet S, ANWAY, Matthew D, ZIRKIN, Barry R

“…The Bcl2 modifying factor (Bmf) is a pro-apoptotic member of the Bcl2 family of apoptosis-related proteins that has been shown to initiate apoptosis in…”
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Transgenerational Effect of the Endocrine Disruptor Vinclozolin on Male Spermatogenesis by Anway, Matthew D, Memon, Mushtaq A, Uzumcu, Mehmet, Skinner, Michael K

“…The current study was designed to examine the actions of a model endocrine disruptor on embryonic testis development and male fertility. Pregnant rats (F0)…”
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