Pharmacological evaluation of carvacrol anti-migraine potential

Pharmacological evaluation of carvacrol anti-migraine potential

Migraine is a devitalizing neurovascular disorder that affects millions of people worldwide. This study was directed against the determination of the effectiveness of carvacrol against migraine. In silico results revealed that carvacrol possesses specific scoring values of − 4.4 to − 6 against selec...

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Bibliographic Details
Published in:Naunyn-Schmiedeberg's archives of pharmacology Vol. 396; no. 6; pp. 1309 - 1324
Main Authors: Anwar, Spogmay, Khan, Arif-ullah, Irshad, Nadeem
Format: Journal Article
Language:English
Published: Berlin/Heidelberg Springer Berlin Heidelberg 01-06-2023
Springer Nature B.V
Subjects:
Animals
Biomedical and Life Sciences
Biomedicine
Carvacrol
Cymenes
Glutathione
Glutathione transferase
Headache
Hyperalgesia
Immunohistochemistry
Inflammation
Interleukin 18
Migraine
Migraine Disorders - drug therapy
Neurosciences
Oxidants
Pain perception
Pharmacology/Toxicology
Prostaglandin E2
Rats
Carvacrol
Anti-oxidant
Anti-inflammatory
Anti-migraine
Molecular docking
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Summary:Migraine is a devitalizing neurovascular disorder that affects millions of people worldwide. This study was directed against the determination of the effectiveness of carvacrol against migraine. In silico results revealed that carvacrol possesses specific scoring values of − 4.4 to − 6 against selected targets. In vivo studies showed that carvacrol (25–50 mg/Kg) decreased migraine pain by reversing thermal allodynia, mechanical allodynia, number of head-scratching, and light phobicity in rats. Levels of glutathione, glutathione-s-transferase, and catalase enhanced in the cortex and trigeminal nucleus caudalis of the animal’s brain tissues, i.e., cortex and trigeminal nucleus caudalis with the use of carvacrol, while a significant decrease in lipid peroxide level was seen. Histopathological evaluation showed improvement in cellular architecture and a decrease in expression of certain inflammatory markers such as tumor necrosis factor-alpha, nuclear factor kappa B, interleukin-18, and prostaglandin E2 validated by enzyme-linked immune sorbent assay, immunohistochemistry, and western blot analysis. This study indicates that carvacrol exhibits binding affinities against different targets involved in migraine pathology and possesses anti-migraine action, mediated through anti-inflammatory and anti-oxidant pathways.
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ISSN:0028-1298
1432-1912
DOI:10.1007/s00210-023-02412-w