Search Results - "Anwar, Khandaker N"

Cornea‐Derived Mesenchymal Stromal Cells Therapeutically Modulate Macrophage Immunophenotype and Angiogenic Function by Eslani, Medi, Putra, Ilham, Shen, Xiang, Hamouie, Judy, Tadepalli, Asha, Anwar, Khandaker N., Kink, John A., Ghassemi, Samaneh, Agnihotri, Gaurav, Reshetylo, Sofiya, Mashaghi, Alireza, Dana, Reza, Hematti, Peiman, Djalilian, Ali R.

“…Macrophages are crucial drivers of inflammatory corneal neovascularization and thus are potential targets for immunomodulatory therapies. We hypothesized that…”
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Bone marrow mesenchymal stromal cells in a 3D system produce higher concentration of extracellular vesicles (EVs) with increased complexity and enhanced neuronal growth properties by Jalilian, Elmira, Massoumi, Hamed, Bigit, Bianca, Amin, Sohil, Katz, Eitan A, Guaiquil, Victor H, Anwar, Khandaker N, Hematti, Peiman, Rosenblatt, Mark I, Djalilian, Ali R

“…Extracellular vesicles (EVs) derived from mesenchymal stromal cells (MSCs) have been demonstrated to possess great potential in preclinical models. An…”
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The effect of decellularization protocols on characterizations of thermoresponsive and light-curable corneal extracellular matrix hydrogels by Yazdanpanah, Ghasem, Jalilian, Elmira, Shen, Xiang, Anwar, Khandaker N., Jiang, Yizhou, Jabbehdari, Sayena, Rosenblatt, Mark I., Pan, Yayue, Djalilian, Ali R.

“…To compare the effects of two decellularization protocols on the characteristics of fabricated COrnea Matrix (COMatrix) hydrogels. Porcine corneas were…”
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Exploring Hydrogel Nanoparticle Systems for Enhanced Ocular Drug Delivery by Arabpour, Zohreh, Salehi, Majid, An, Seungwon, Moghtader, Amirhossein, Anwar, Khandaker N, Baharnoori, Seyed Mahbod, Shah, Rohan Jaimin, Abedi, Farshad, Djalilian, Ali R

“…Drug delivery to the ocular system is affected by anatomical factors like the corneal epithelium, blinking reflex, aqueous blood barrier, and retinal blood…”
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Critical role of non-muscle myosin light chain kinase in thrombin-induced endothelial cell inflammation and lung PMN infiltration by Fazal, Fabeha, Bijli, Kaiser M, Murrill, Matthew, Leonard, Antony, Minhajuddin, Mohammad, Anwar, Khandaker N, Finkelstein, Jacob N, Watterson, D Martin, Rahman, Arshad

“…The pathogenesis of acute lung injury (ALI) involves bidirectional cooperation and close interaction between inflammatory and coagulation pathways. A key…”
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A Light‐Curable and Tunable Extracellular Matrix Hydrogel for In Situ Suture‐Free Corneal Repair by Yazdanpanah, Ghasem, Shen, Xiang, Nguyen, Tara, Anwar, Khandaker N., Jeon, Oju, Jiang, Yizhou, Pachenari, Mohammad, Pan, Yayue, Shokuhfar, Tolou, Rosenblatt, Mark I., Alsberg, Eben, Djalilian, Ali R.

“…Corneal injuries are a major cause of blindness worldwide. To restore corneal integrity and clarity, there is a need for regenerative biointegrating materials…”
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LPS activation of Toll-like receptor 4 signals CD11b/CD18 expression in neutrophils by Zhou, Ximing, Gao, Xiao-Pei, Fan, Jie, Liu, Qinghui, Anwar, Khandaker N, Frey, Randall S, Malik, Asrar B

“…We identify herein a novel signaling function of the Toll-like receptor-4 (TLR4), the lipopolysaccharide (LPS) receptor mediating the innate immune response,…”
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Staphylococcus aureus alpha-hemolysin impairs corneal epithelial wound healing and promotes intracellular bacterial invasion by Putra, Ilham, Rabiee, Behnam, Anwar, Khandaker N., Gidfar, Sanaz, Shen, Xiang, Babalooee, Mehrdad, Ghassemi, Mahmood, Afsharkhamseh, Neda, Bakhsh, Saaquib, Missiakas, Dominique, Nezamabadi, Ali, Milani, Behrad, Eslani, Medi, Djalilian, Ali R.

“…Colonization by Staphylococcus aureus (S. aureus) has been implicated in many infectious and wound healing disorders. This study was performed to characterize…”
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Gene dosage manipulation alleviates manifestations of hereditary PAX6 haploinsufficiency in mice by Rabiee, Behnam, Anwar, Khandaker N, Shen, Xiang, Putra, Ilham, Liu, Mingna, Jung, Rebecca, Afsharkhamseh, Neda, Rosenblatt, Mark I, Fishman, Gerald A, Liu, Xiaorong, Ghassemi, Mahmood, Djalilian, Ali R

“…In autosomal dominant conditions with haploinsufficiency, a single functional allele cannot maintain sufficient dosage for normal function. We hypothesized…”
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Therapeutic Effects of Lyophilized Conditioned-Medium Derived from Corneal Mesenchymal Stromal Cells on Corneal Epithelial Wound Healing by Jabbehdari, Sayena, Yazdanpanah, Ghasem, Kanu, Levi N., Chen, Eric, Kang, Kai, Anwar, Khandaker N., Ghassemi, Mahmood, Hematti, Peiman, Rosenblatt, Mark I., Djalilian, Ali R.

“…Objectives: The conditioned-medium derived from corneal mesenchymal stromal cells (cMSCs) has been shown to have wound healing and immunomodulatory effects in…”
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Intrastromal versus subconjunctival injection of mesenchymal stem/stromal cells for promoting corneal repair by Soleimani, Mohammad, Mirshahi, Reza, Cheraqpour, Kasra, Baharnoori, Seyed Mahbod, Massoumi, Hamed, Chow, Collin, Shahjahan, Sumaiya, Momenaei, Bita, Ashraf, Mohammad Javad, Koganti, Raghuram, Ghassemi, Mahmood, Anwar, Khandaker N., Jalilian, Elmira, Djalilian, Ali R.

“…Different approaches to delivery of mesenchymal stem/stromal cells (MSCs) for ameliorating corneal injuries have been investigated. This study was aimed to…”
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In-situ porcine corneal matrix hydrogel as ocular surface bandage by Yazdanpanah, Ghasem, Shah, Ritu, Raghurama R Somala, Sri, Anwar, Khandaker N., Shen, Xiang, An, Seungwon, Omidi, Meisam, Rosenblatt, Mark I., Shokuhfar, Tolou, Djalilian, Ali R.

“…Bioactive substrates can be used therapeutically to enhance wound healing. Here, we evaluated the effect of an in-situ thermoresponsive hydrogel from…”
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Dose-dependent therapeutic effects of topical 1,25 OH-vitamin D3 on corneal wound healing by Jabbehdari, Sayena, Yazdanpanah, Ghasem, Chen, Eric, Afsharkhamseh, Neda, Ghassemi, Mahmood, Anwar, Khandaker N., Fonteh, Cheryl, Djalilian, Ali R., Kang, Kai B.

“…Conflicting results have been reported regarding the effects of 1,25 OH-vitamin D 3 on corneal wound healing. Therefore, we undertook this study to determine…”
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RhoA/Rho-associated kinase pathway selectively regulates thrombin-induced intercellular adhesion molecule-1 expression in endothelial cells via activation of I kappa B kinase beta and phosphorylation of RelA/p65 by Anwar, Khandaker N, Fazal, Fabeha, Malik, Asrar B, Rahman, Arshad

“…We investigated the involvement of the RhoA/Rho-associated kinase (ROCK) pathway in regulating ICAM-1 expression in endothelial cells by the procoagulant,…”
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Preclinical Evaluation of the Safety and Efficacy of Cryopreserved Bone Marrow Mesenchymal Stromal Cells for Corneal Repair by Putra, Ilham, Shen, Xiang, Anwar, Khandaker N, Rabiee, Behnam, Samaeekia, Ravand, Almazyad, Enmar, Giri, Pushpanjali, Jabbehdari, Sayena, Hayat, Mohammed R, Elhusseiny, Abdelrahman M, Ghassemi, Mahmood, Mahmud, Nadim, Edward, Deepak P, Joslin, Charlotte E, Rosenblatt, Mark I, Dana, Reza, Eslani, Medi, Hematti, Peiman, Djalilian, Ali R

“…Mesenchymal stromal cells (MSCs) have been shown to enhance tissue repair as a cell-based therapy. In preparation for a phase I clinical study, we evaluated…”
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Reproducible Derivation and Expansion of Corneal Mesenchymal Stromal Cells for Therapeutic Applications by Jabbehdari, Sayena, Yazdanpanah, Ghasem, Kanu, Levi N, Anwar, Khandaker N, Shen, Xiang, Rabiee, Behnam, Putra, Ilham, Eslani, Medi, Rosenblatt, Mark I, Hematti, Peiman, Djalilian, Ali R

“…A reproducible protocol for the production of corneal mesenchymal stem/stromal cells (cMSCs) is necessary for potential clinical applications. We aimed to…”
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In vitro antiretroviral activity and in vivo toxicity of the potential topical microbicide copper phthalocyanine sulfate by Styczynski, Ashley R, Anwar, Khandaker N, Sultana, Habiba, Ghanem, Abdelhamid, Lurain, Nell, Chua, Aishi, Ghassemi, Mahmood, Novak, Richard M

“…Copper has antimicrobial properties and has been studied for its activity against viruses, including HIV. Copper complexed within a phthalocyanine ring,…”
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Gαq and Gβγ Regulate PAR-1 Signaling of Thrombin-Induced NF-κB Activation and ICAM-1 Transcription in Endothelial Cells by Rahman, Arshad, True, Andrea L, Anwar, Khandaker N, Ye, Richard D, Voyno-Yasenetskaya, Tatyana A, Malik, Asrar B

“…ABSTRACT—As thrombin binding to the G protein–coupled proteinase activated receptor-1 (PAR-1) induces endothelial adhesivity to leukocytes through NF-κB…”
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Tumor Necrosis Factor-α Induces Early-Onset Endothelial Adhesivity by Protein Kinase Cζ–Dependent Activation of Intercellular Adhesion Molecule-1 by Javaid, Kamran, Rahman, Arshad, Anwar, Khandaker N, Frey, Randall S, Minshall, Richard D, Malik, Asrar B

“…ABSTRACT—We tested the hypothesis that TNF-α induces early-onset endothelial adhesivity toward PMN by activating the constitutive endothelial cell surface…”
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Protein Kinase C-δ Regulates Thrombin-Induced ICAM-1 Gene Expression in Endothelial Cells via Activation of p38 Mitogen-Activated Protein Kinase by Rahman, Arshad, Anwar, Khandaker N., Uddin, Shahab, Xu, Ning, Ye, Richard D., Platanias, Leonidas C., Malik, Asrar B.

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