Search Results - "Anur, Praveen"
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A numerical analysis model for interpretation of flow cytometric studies of ex vivo phagocytosis
Published in PloS one (04-11-2011)“…The study of ex vivo phagocytosis via flow cytometry requires that one distinguish experimentally between uptake and adsorption of fluorescently labeled…”
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Genetic disruption of both Fancc and Fancg in mice recapitulates the hematopoietic manifestations of Fanconi anemia
Published in Blood (21-10-2010)“…Fanconi anemia (FA) is an inherited chromosomal instability syndrome characterized by bone marrow failure, myelodysplasia (MDS), and acute myeloid leukemia…”
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Late effects in patients with Fanconi anemia following allogeneic hematopoietic stem cell transplantation from alternative donors
Published in Bone marrow transplantation (Basingstoke) (01-07-2016)“…Hematopoietic stem cell transplantation (HSCT) is curative for hematological manifestations of Fanconi anemia (FA). We performed a retrospective analysis of 22…”
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Fancd2−/− mice have hematopoietic defects that can be partially corrected by resveratrol
Published in Blood (09-12-2010)“…Progressive bone marrow failure is a major cause of morbidity and mortality in human Fanconi Anemia patients. In an effort to develop a Fanconi Anemia murine…”
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TLR8-dependent TNF-α overexpression in Fanconi anemia group C cells
Published in Blood (17-12-2009)“…Tumor necrosis factor alpha (TNF-α) production is abnormally high in Fanconi anemia (FA) cells and contributes to the hematopoietic defects seen in FA…”
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p38 MAPK inhibition suppresses the TLR-hypersensitive phenotype in FANCC- and FANCA-deficient mononuclear phagocytes
Published in Blood (01-03-2012)“…Fanconi anemia, complementation group C (FANCC)–deficient hematopoietic stem and progenitor cells are hypersensitive to a variety of inhibitory cytokines, one…”
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Late Effects Following Allogeneic Hematopoietic Stem Cell Transplantation (HSCT) From Alternative Donors In Patients With Fanconi Anemia (FA)
Published in Blood (15-11-2013)“…Hematopoietic Stem Cell Transplantation is the only curative approach for the hematological complications of Fanconi Anemia. However, patients with FA remain…”
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Kinase Inhibitors Reduce TNF-Alpha Over-Production in Monocytes From Fanconi Anemia Group A Patients
Published in Blood (18-11-2011)“…Abstract 2409 Fanconi Anemia (FA) is a chromosomal instability syndrome with hypersensitivity to alkylating agents as principal diagnostic feature. Many…”
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Platelets From WAS Patients Are More Susceptible Than Controls to Phagocytosis by Activated THP-1 Cells
Published in Blood (18-11-2011)“…Abstract 2222 The thrombocytopenia associated with the Wiskott-Aldrich Syndrome (WAS) is thought to be due to the combined effects of impaired platelet…”
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The evolving spectrum of ‘non‐classical’ Diamond‐Blackfan anaemia – a case of eADA positive pancytopenia in a young adult
Published in British journal of haematology (01-05-2009)Get full text
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Platelets from WAS patients show an increased susceptibility to ex vivo phagocytosis
Published in Platelets (Edinburgh) (01-01-2013)“…The thrombocytopenia of Wiskott-Aldrich syndrome (WAS) is thought to be due to both reduced platelet production and accelerated platelet consumption. We have…”
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Clonal Evolution In Fanconi Anemia; The Role of HOXA9
Published in Blood (19-11-2010)“…Abstract 126 Bone marrow failure in patients with Fanconi anemia (FA) is often complicated by the clonal neoplasms myelodysplasia (MDS) and acute myelogenous…”
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A High Throughput Small Molecule Screening Method for Fanconi Anemia
Published in Blood (20-11-2009)“…Abstract 3191 Poster Board III-128 The Fanconi Anemia (FA) proteins play an important role in regulating genome stability, but there is little evidence that…”
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TNFα Overproduction in FANCC-Deficient Cells Is TLR8 Dependent
Published in Blood (20-11-2009)“…Abstract 494 The Fanconi anemia (FA) proteins play a role in regulating genome stability but it is not clear that loss of genoprotection in FA hematopoietic…”
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TLR8-dependent TNF-(alpha) overexpression in Fanconi anemia group C cells
Published in Blood (17-12-2009)“…Tumor necrosis factor alpha (TNF-alpha) production is abnormally high in Fanconi anemia (FA) cells and contributes to the hematopoietic defects seen in FA…”
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