Search Results - "Antunes, Natalicia J."

Quantification of cyclic AMP and cyclic GMP levels in Krebs-Henseleit solution by LC-MS/MS: Application in washed platelet aggregation samples by Nash, Charles Elliot Serpellone, Antunes, Natalícia J., Coelho-Silva, Weverton C., Campos, Rafael, De Nucci, Gilberto

“…•For the first time, nucleotide level is measured in washed platelet by LC-MS/MS.•This method shows high precision with the lowest LLoQ to date for cAMP and…”
Get full text

Quantification of 6-nitrodopamine in Krebs-Henseleit’s solution by LC-MS/MS for the assessment of its basal release from Chelonoidis carbonaria aortae in vitro by Campos, Rafael, Pinheiro, David Halen Araújo, Britto-Júnior, José, de Castro, Heleson Alves, Mendes, Gustavo Duarte, Moraes, Manoel Odorico, Moraes, Maria Elisabete A., Lopes-Martins, Rodrigo Álvaro Brandão, Antunes, Natalícia J., De Nucci, Gilberto

“…•A novel method for analysis of 6-nitrodopamine in Krebs-Henseleit’s solution is presented.•The method was linear in the range of 0.1–20.0 ng/mL.•Tortoise’s…”
Get full text

Quantification of estradiol cypionate in plasma by liquid chromatography coupled with tandem mass spectrometry: Application in a pharmacokinetic study in healthy female volunteers by Martins, Roberto Salvador, Antunes, Natalícia J., Comerlatti, Guilherme, Caraccio, Gabriela, Moreno, Ronilson A., Frecentese, Francesco, Caliendo, Giuseppe, De Nucci, Gilberto

“…•For the first time, this study presents the development and validation of a sensitive method for analysis of estradiol cypionate in human plasma by…”
Get full text

Simultaneous quantification of cyclosporin, tacrolimus, sirolimus and everolimus in whole blood by UHPLC–MS/MS for therapeutic drug monitoring by Antunes, Natalicia J., Kipper, Karin, Couchman, Lewis, Duncan, Marie‐Anne, Holt, David W., De Nucci, Gilberto, Johnston, Atholl

“…The aim of this study was to develop and validate a UHPLC–MS/MS assay to quantify cyclosporin (CYC), tacrolimus (TAC), sirolimus (SIR) and everolimus (EVE) in…”
Get full text

Randomized, double‐blind, phase III clinical study of a novel nanotechnological topical anesthetic formulation containing lidocaine 25 mg/g and prilocaine 25 mg/g (nanorap) in skin phototypes I–III patients with ablative fractional CO2 laser treatment indication in the forehead by Gobbato, Cíntia, Gobbato, André, Magalhães, Tainah B., Mendes, Gustavo D., Ilha, Jaime O., Moreno, Ronilson A., Antunes, Natalícia J., De Nucci, Gilberto

“…Background and Objectives Nanotechnology may increase the speed of penetration into the skin. This study evaluated the efficacy, safety, and pharmacokinetics…”
Get full text

Impact of Bariatric Surgery on the Pharmacokinetics Parameters of Amoxicillin by Rocha, Marina Becker Sales, De Nucci, Gilberto, Lemos, Francisco Ney, de Albuquerque Lima Babadopulos, Rodrigo Feitosa, Rohleder, Andrea Vieira Pontes, Fechine, Francisco Vagnaldo, Antunes, Natalícia J., Mendes, Gustavo D., do Nascimento, Demetrius Fernandes, de Moraes, Manoel Odorico, de Moraes, Maria Elisabete Amaral

“…Background Bariatric surgery leads to several anatomo-physiological modifications that may affect pharmacokinetic parameters and consequently alter the…”
Get full text

Development, Validation of LC-MS/MS Method and Determination of Pharmacokinetic Parameters of the Stroke Neuroprotectant Neurounina-1 in Beagle Dog Plasma After Intravenous Administration by Severino, Beatrice, Corvino, Angela, Fiorino, Ferdinando, Frecentese, Francesco, Perissutti, Elisa, Caliendo, Giuseppe, Santagada, Vincenzo, Magli, Elisa, Molinaro, Pasquale, Pignataro, Giuseppe, Annunziato, Lucio, Antunes, Natalícia J, Rojas-Moscoso, Julio, de Freitas, Noedi L, Mendes, Gustavo D, De Nucci, Gilberto

“…Neurounina-1 [chemical name: 7-nitro-5-phenyl-1-(pyrrolidin-1-ylmethyl)-1H-benzo[e][1,4]diazepin-2(3H)-one] is a new compound provided with relevant…”
Get full text

Influence of gestational diabetes mellitus on the stereoselective kinetic disposition and metabolism of labetalol in hypertensive patients by Carvalho, Teresa Maria J. P, de Carvalho Cavalli, Ricardo, Cunha, Sérgio P, de Baraldi, Cláudia O, Marques, Maria P, Antunes, Natalícia J, Godoy, Ana Leonor P. C, Lanchote, Vera Lucia

“…Purpose This study investigated the influence of gestational diabetes mellitus on the kinetic disposition and stereoselective metabolism of labetalol…”
Get full text

Quantification of mycophenolic acid in human plasma by liquid chromatography with time‐of‐flight mass spectrometry for therapeutic drug monitoring by Antunes, Natalicia J., Ince, Nina, Raymond, Jason, Kipper, Karin, Couchman, Lewis, Holt, David W., De Nucci, Gilberto, Johnston, Atholl

“…This study presents, for the first time, the development and validation of a liquid chromatography and time‐of‐flight mass‐spectrometry (LC–TOF–MS) based assay…”
Get full text

Quantification of Plasma and Urine Thymidine and 2'-Deoxyuridine by LC-MS/MS for the Pharmacodynamic Evaluation of Erythrocyte Encapsulated Thymidine Phosphorylase in Patients with Mitochondrial Neurogastrointestinal Encephalomyopathy by Kipper, Karin, Hecht, Max, Antunes, Natalicia J, Fairbanks, Lynette D, Levene, Michelle, Kalkan Uçar, Sema, Schaefer, Andrew, Blakely, Emma L, Bax, Bridget E

“…Mitochondrial neurogastrointestinal encephalomyopathy (MNGIE) is an ultra-rare disorder caused by mutations in , leading to a deficiency in thymidine…”
Get full text

Determination of dopamine, noradrenaline, and adrenaline in Krebs–Henseleit solution by liquid chromatography coupled with tandem mass spectrometry and measurement of their basal release from Chelonoidis carbonaria aortae in vitro by Britto‐Júnior, José, Antunes, Natalícia J., Campos, Rafael, Sucupira, Mauro, Mendes, Gustavo Duarte, Fernandes, Fernanda, Moraes, Manoel Odorico, Moraes, Maria Elisabete A., De Nucci, Gilberto

“…This study presented for the first time the development and validation of a sensitive method for quantification of dopamine, noradrenaline, and adrenaline in…”
Get full text

Randomized, double-blind, phase III clinical study of a novel nanotechnological topical anesthetic formulation containing lidocaine 25 mg/g and prilocaine 25 mg/g (nanorap) in skin phototypes I-III patients with ablative fractional CO 2 laser treatment indication in the forehead by Gobbato, Cíntia, Gobbato, André, Magalhães, Tainah B, Mendes, Gustavo D, Ilha, Jaime O, Moreno, Ronilson A, Antunes, Natalícia J, De Nucci, Gilberto

“…Nanotechnology may increase the speed of penetration into the skin. This study evaluated the efficacy, safety, and pharmacokinetics of a novel topical…”
Get full text

Randomized, double‐blind, phase III clinical study of a novel nanotechnological topical anesthetic formulation containing lidocaine 25mg/g and prilocaine 25mg/g (nanorap) in skin phototypes I–III patients with ablative fractional CO2 laser treatment indication in the forehead by Gobbato, Cíntia, Gobbato, André, Magalhães, Tainah B, Mendes, Gustavo D, Ilha, Jaime O, Moreno, Ronilson A, Antunes, Natalícia J, De Nucci, Gilberto

“…Background and ObjectivesNanotechnology may increase the speed of penetration into the skin. This study evaluated the efficacy, safety, and pharmacokinetics of…”
Get full text