Search Results - "Antunes, Krist Helen"

Microbiota-derived acetate protects against respiratory syncytial virus infection through a GPR43-type 1 interferon response by Antunes, Krist Helen, Fachi, José Luís, de Paula, Rosemeire, da Silva, Emanuelle Fraga, Pral, Laís Passariello, dos Santos, Adara Áurea, Dias, Greicy Brisa Malaquias, Vargas, José Eduardo, Puga, Renato, Mayer, Fabiana Quoos, Maito, Fábio, Zárate-Bladés, Carlos R., Ajami, Nadim J., Sant’Ana, Marcella Ramos, Candreva, Thamiris, Rodrigues, Hosana Gomes, Schmiele, Marcio, Silva Clerici, Maria Teresa Pedrosa, Proença-Modena, José Luiz, Vieira, Angélica Thomas, Mackay, Charles R., Mansur, Daniel, Caballero, Mauricio T., Marzec, Jacqui, Li, Jianying, Wang, Xuting, Bell, Douglas, Polack, Fernando P., Kleeberger, Steven R., Stein, Renato T., Vinolo, Marco Aurélio Ramirez, de Souza, Ana Paula Duarte

“…Severe respiratory syncytial virus (RSV) infection is a major cause of morbidity and mortality in infants <2 years-old. Here we describe that high-fiber diet…”
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Impact of Microbiota Depletion by Antibiotics on SARS-CoV-2 Infection of K18-hACE2 Mice by Rodrigues, Patrícia Brito, Gomes, Giovanni Freitas, Angelim, Monara K. S. C, Souza, Gabriela F, Muraro, Stefanie Primon, Toledo-Teixeira, Daniel A, Rattis, Bruna Amanda Cruz, Passos, Amanda Stephane, Pral, Laís Passarielo, de Rezende Rodovalho, Vinícius, dos Santos P. Gomes, Arilson Bernardo, Matheus, Valquíria Aparecida, Antunes, André Saraiva Leão Marcelo, Crunfli, Fernanda, Antunes, Krist Helen, de Souza, Ana Paula Duarte, Consonni, Sílvio Roberto, Leiria, Luiz Osório, Alves-Filho, José Carlos, Cunha, Thiago M, Moraes-Vieira, Pedro M. M, Proença-Módena, José Luiz, R. Vinolo, Marco Aurélio

“…Clinical and experimental data indicate that severe acute respiratory syndrome coronavirus (SARS-CoV)-2 infection is associated with significant changes in the…”
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Cytotoxic Effects of Diclofenac and Ibuprofen Zinc (II)-Nicotinamide Ternary Complexes in Breast Cancer Cell Lines by Silva, Emanuelle Fraga da, Santos, Paulo Roberto dos, Fernandes, Krist Helen Antunes, Freitas, Deise do Nascimento de, Zanin, Rafael Fernandes, Machado, Pablo, Moura, Sidnei, Souza, Ana Paula Duarte de

“…Abstract Breast cancer is one of the leading types of cancer worldwide, and the search for new treatment options are crucial. Nonsteroidal anti-inflammatory…”
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SARS-CoV-2 immune complex triggers human monocyte necroptosis by Santos, Leonardo Duarte, Antunes, Krist Helen, Cassão, Gisele, Gonçalves, João Ismael, Abbadi, Bruno Lopes, Bizarro, Cristiano Valim, Basso, Luiz Augusto, Machado, Pablo, de Souza, Ana Paula D., Porto, Bárbara Nery

“…We analyzed the ability of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) itself and SARS-CoV-2-IgG immune complexes to trigger human monocyte…”
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Anti-tumor effects of valproate zinc complexes on a lung cancer cell line by Fraga da Silva, Emanuelle, Roberto dos Santos, Paulo, Helen Antunes, Krist, Marinho Franceschina, Caroline, Nascimento de Freitas, Deise, Konrad, Priscila, Fernandes Zanin, Rafael, Machado, Pablo, Moura, Sidnei, de Souza, Ana Paula Duarte

“…The ternary complexes containing Zn+2, valproate, and 2,2′-bipyridine (complex 1) and nicotinamide (complex 2) showed anti-tumor effect on a lung cancer cell…”
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Fructose‐1,6‐bisphosphate induces generation of reactive oxygen species and activation of p53‐dependent cell death in human endometrial cancer cells by Costa, Bruna Pasqualotto, Nassr, Marcella Tornquist, Diz, Fernando Mendonça, Carlessi, Leonardo Pfeiff, Fernandes, Krist Helen Antunes, Nunes, Fernanda Bordignon, Branchini, Gisele, Oliveira, Jarbas Rodrigues

“…Fructose‐1,6‐bisphosphate (F1,6BP), an intermediate of the glycolytic pathway, has been found to play a promising anticancer effect; nevertheless, the…”
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Airway Administration of Bacterial Lysate OM-85 Protects Mice Against Respiratory Syncytial Virus Infection by Antunes, Krist Helen, Cassão, Gisele, Santos, Leonardo Duarte, Borges, Sofia Giacomet, Poppe, Juliana, Gonçalves, João Budelon, Nunes, Eduarda da Silva, Recacho, Guilherme Fernando, Sousa, Vitória Barbosa, Da Silva, Gabriela Souza, Mansur, Daniel, Stein, Renato T, Pasquali, Christian, De Souza, Ana Paula Duarte

“…Respiratory syncytial virus (RSV) is a seasonal pathogen responsible for the highest percentage of viral bronchiolitis in pediatric patients. There are…”
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Respiratory syncytial virus reduces STAT3 phosphorylation in human memory CD8 T cells stimulated with IL-21 by Antunes, Krist Helen, Becker, André, Franceschina, Caroline, de Freitas, Deise do Nascimento, Lape, Isadora, da Cunha, Mariana D’Ávila, Leitão, Lidiane, Rigo, Mauricio M., Pinto, Leonardo Araújo, Stein, Renato T., de Souza, Ana Paula Duarte

“…Respiratory syncytial virus (RSV) is a common cause of childhood lower respiratory tract infections. The recent failure of a vaccine candidate based on…”
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Methoxyeugenol regulates the p53/p21 pathway and suppresses human endometrial cancer cell proliferation by Costa, Bruna Pasqualotto, Nassr, Marcella Tornquist, Diz, Fernando Mendonça, Fernandes, Krist Helen Antunes, Antunes, Géssica Luana, Grun, Lucas Kich, Barbé-Tuana, Florencia María, Nunes, Fernanda Bordignon, Branchini, Gisele, de Oliveira, Jarbas Rodrigues

“…Plant-derived compounds are a reservoir of natural chemicals and can act as drug precursors or prototypes and pharmacological probes. Methoxyeugenol is a…”
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Brief research report: OM-85 reduces SARS-COV-2 viral RNA expression in nasopharyngeal cells from COVID-19 patients by Cassão, Gisele, Antunes, Krist Helen, Gonçalvez, João Ismael Budelon, Santos, Leonardo Duarte, Abbadi, Bruno Lopes, Bizarro, Cristiano Valim, Machado, Pablo, Basso, Luiz Augusto, Pasquali, Christian, Stein, Renato T., de Souza, Ana Paula Duarte

“…OM-85 is a bacterial lysate from common respiratory tract pathogens, with an excellent safety profile, widely used to prevent recurrent respiratory tract…”
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Therapeutic effect of uridine phosphorylase 1 (UPP1) inhibitor on liver fibrosis in vitro and in vivo by Gonçalves da Silva, Elisa Feller, Costa, Bruna Pasqualotto, Nassr, Marcella Tornquist, de Souza Basso, Bruno, Bastos, Matheus Scherer, Antunes, Géssica Luana, Reghelin, Camille Kirinus, Rosa Garcia, Maria Claudia, Schneider Levorse, Vitor Giancarlo, Carlessi, Leonardo Pfeiff, Antunes Fernandes, Krist Helen, Richter Schmitz, Carine Raquel, Haute, Gabriela Viegas, Luft, Carolina, Santarém, Eliane, Barbé-Tuana, Florencia María, Donadio, Márcio Vinícius Fagundes, Basso, Luiz Augusto, Machado, Pablo, Rodrigues de Oliveira, Jarbas

“…Potassium 5-cyano-4-methyl-6-oxo-1,6-dihydropyridine-2-olate (CPBMF65) is a potent inhibitor of the uridine phosphorylase 1 (UPP1) enzyme. Its non-ionized…”
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New triazole-substituted triterpene derivatives exhibiting anti-RSV activity: synthesis, biological evaluation, and molecular modeling by da Silva, Elenilson F, Antunes Fernandes, Krist Helen, Diedrich, Denise, Gotardi, Jessica, Freire Franco, Marcia Silvana, Tomich de Paula da Silva, Carlos Henrique, Duarte de Souza, Ana Paula, Baggio Gnoatto, Simone Cristina

“…Respiratory syncytial virus (RSV) is a major cause of acute lower respiratory tract infections in infants. Currently, ribavirin, a nucleoside analog containing…”
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Effect of LPS on the Viability and Proliferation of Human Oral and Esophageal Cancer Cell Lines by Gonçalves, Márcia, Cappellari, Ángelica Regina, Santos Junior, André Avelino dos, Marchi, Fernanda Olicheski de, Macchi, Fernanda Souza, Antunes, Krist Helen, Souza, Ana Paula Duarte de, Morrone, Fernanda Bueno

“…The esophagus and mouth tumors are very frequent malignancies worldwide. Lipopolysaccharides (LPS) are capable of regulating gene expression of…”
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TNF-mediated alveolar macrophage necroptosis drives disease pathogenesis during respiratory syncytial virus infection by Santos, Leonardo Duarte, Antunes, Krist Helen, Muraro, Stéfanie Primon, de Souza, Gabriela Fabiano, da Silva, Amanda Gonzalez, Felipe, Jaqueline de Souza, Zanetti, Larissa Cardoso, Czepielewski, Rafael Sanguinetti, Magnus, Karen, Scotta, Marcelo, Mattiello, Rita, Maito, Fabio, de Souza, Ana Paula Duarte, Weinlich, Ricardo, Vinolo, Marco Aurélio Ramirez, Porto, Bárbara Nery

“…Respiratory syncytial virus (RSV) is the major cause of acute bronchiolitis in infants under 2 years old. Necroptosis has been implicated in the outcomes of…”
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Airway-delivered short-chain fatty acid acetate boosts antiviral immunity during rhinovirus infection by Antunes, Krist Helen, Singanayagam, Aran, Williams, Lily, Faiez, Tasnim Syakirah, Farias, Ana, Jackson, Millie M., Faizi, Fatima K., Aniscenko, Julia, Kebadze, Tatiana, Chander Veerati, Punnam, Wood, Lisa, Bartlett, Nathan W., Duarte de Souza, Ana Paula, Johnston, Sebastian L.

“…Microbiota are recognized to play a major role in regulation of immunity through release of immunomodulatory metabolites such as short-chain fatty acids…”
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Impact of angiotensin II type 1 and G-protein-coupled Mas receptor expression on the pulmonary performance of patients with idiopathic pulmonary fibrosis by Raupp, Débora, Fernandes, Renata Streck, Antunes, Krist Helen, Perin, Fabíola Adélia, Rigatto, Katya

“…•Renin-angiotensin system has been neglected in pulmonary physipathology.•In the lung tissue of IPF patients AT1R expression is increased while MasR is…”
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Correction to: Coumaric acid from M. polymorphum extracts reverses the activated state of hepatic stellate cells (GRX) and inhibits their proliferation by decreasing the p53/p21 pathway by Bastos, Matheus Scherer, Saalfeld, Rafaela Mallmann, Costa, Bruna Pasqualotto, Antunes, Krist Helen, Melo, Denizar, Donadio, Márcio Vinicius Fagundes, Santarém, Eliane Romanato, de Oliveira, Jarbas Rodrigues

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Moquiniastrum polymorphum subsp. polymorphum extract inhibits the proliferation of an activated hepatic stellate cell line (GRX) by regulating the p27 pathway to generate cell cycle arrest by Bastos, Matheus Scherer, Saalfeld, Rafaela Mallmann, Costa, Bruna Pasqualotto, Garcia, Maria Claudia, Antunes, Krist Helen, Rodrigues, Kétlin Fernanda, Melo, Denizar, Santarém, Eliane Romanato, de Oliveira, Jarbas Rodrigues

“…The chosen plant and its extracts have been an alternative in the treatment of several inflammatory and oxidant diseases, and is therefore a viable option for…”
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Coumaric acid from M. polymorphum extracts reverses the activated state of hepatic stellate cells (GRX) and inhibits their proliferation by decreasing the p53/p21 pathway by Bastos, Matheus Scherer, Saalfeld, Rafaela Mallmann, Costa, Bruna Pasqualotto, Antunes, Krist Helen, Melo, Denizar, Donadio, Márcio Vinicius Fagundes, Santarém, Eliane Romanato, de Oliveira, Jarbas Rodrigues

“…Coumaric acid is a phenolic compound found in medicinal plants. Its use has been reported in the treatment of inflammatory diseases, prevention of alterations…”
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Extracellular DNA in sputum is associated with pulmonary function and hospitalization in patients with cystic fibrosis by Piva, Taila Cristina, Luft, Carolina, Antunes, Krist Helen, Marostica, Paulo José Cauduro, Pinto, Leonardo Araújo, Donadio, Márcio Vinícius Fagundes

“…Elevated extracellular DNA levels are found in the sputum of patients with cystic fibrosis (CF). However, studies investigating the association of…”
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