Search Results - "Antunes, Inês F"

Arginase as a Potential Biomarker of Disease Progression: A Molecular Imaging Perspective by S Clemente, Gonçalo, van Waarde, Aren, F Antunes, Inês, Dömling, Alexander, H Elsinga, Philip

“…Arginase is a widely known enzyme of the urea cycle that catalyzes the hydrolysis of L-arginine to L-ornithine and urea. The action of arginase goes beyond the…”
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[18F]Atorvastatin Pharmacokinetics and Biodistribution in Healthy Female and Male Rats by Clemente, Gonçalo S, Antunes, Inês F, Sijbesma, Jürgen W. A, van Waarde, Aren, Lammertsma, Adriaan A, Dömling, Alexander, Elsinga, Philip H

“…Statins are 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors that are widely used to prevent cardiovascular diseases. However, a series of…”
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Development and Evaluation of Interleukin-2-Derived Radiotracers for PET Imaging of T Cells in Mice by van der Veen, Elly L, Suurs, Frans V, Cleeren, Frederik, Bormans, Guy, Elsinga, Philip H, Hospers, Geke A P, Lub-de Hooge, Marjolijn N, de Vries, Elisabeth G E, de Vries, Erik F J, Antunes, Inês F

“…Recently, -(4- F-fluorobenzoyl)-interleukin-2 ( F-FB-IL2) was introduced as a PET tracer for T cell imaging. However, production is complex and time-consuming…”
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GMP Compliant Synthesis of [18F]Canagliflozin, a Novel PET Tracer for the Sodium–Glucose Cotransporter 2 by van der Hoek, Sjoukje, Antunes, Inês F, Attia, Khaled A, Jacquet, Olivier, Heeres, Andre, Bulthuis, Marian, Zijlma, Rolf, Boersma, Hendrikus H, van Goor, Harry, Visser, Ton J, Heerspink, Hiddo J. L, Elsinga, Philip H, Stevens, Jasper

“…Inhibition of the sodium–glucose cotransporter 2 (SGLT2) by canagliflozin in type 2 diabetes mellitus results in large between-patient variability in clinical…”
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Patient-derived parathyroid organoids as a tracer and drug-screening application model by Noltes, Milou E., Sondorp, Luc H.J., Kracht, Laura, Antunes, Inês F., Wardenaar, René, Kelder, Wendy, Kemper, Annelies, Szymanski, Wiktor, Zandee, Wouter T., Jansen, Liesbeth, Brouwers, Adrienne H., Coppes, Robert P., Kruijff, Schelto

“…Parathyroid diseases are characterized by dysregulation of calcium homeostasis and alterations in parathyroid hormone (PTH) excretion. The development of…”
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[18F]Atorvastatin: synthesis of a potential molecular imaging tool for the assessment of statin-related mechanisms of action by Clemente, Gonçalo S., Rickmeier, Jens, Antunes, Inês F., Zarganes-Tzitzikas, Tryfon, Dömling, Alexander, Ritter, Tobias, Elsinga, Philip H.

“…Background Statins are lipid-lowering agents that inhibit cholesterol synthesis and are clinically used in the primary and secondary prevention of…”
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Induction of β‑Glucuronidase Release by Cytostatic Agents in Small Tumors by F. Antunes, Inês, Haisma, Hidde J, Elsinga, Philip H, Di Gialleonardo, Valentina, Waarde, Aren van, Willemsen, Antoon T. M, Dierckx, Rudi A, de Vries, Erik F. J

“…Extracellular β-glucuronidase (β-GUS) in tumors has been investigated as a target enzyme for prodrug therapy. However, despite encouraging preclinical results,…”
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A new approach to produce [18F]MC225 via one-step synthesis, a PET radiotracer for measuring P-gp function by Garcia-Varela, Lara, Attia, Khaled, Sembrano, John Carlo, Jacquet, Olivier, Antunes, Inês F., Kwizera, Chantal, Visser, Ton J., Dierckx, Rudi A. J. O., Elsinga, Philip H., Luurtsema, Gert

“…Background [ 18 F]MC225 is a radiotracer for imaging P-glycoprotein (P-gp) function at the blood-brain barrier. The P-gp function can be altered due to…”
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Clinical-grade N-(4-[18F]fluorobenzoyl)-interleukin-2 for PET imaging of activated T-cells in humans by van der Veen, Elly L., Antunes, Inês F., Maarsingh, Petra, Hessels-Scheper, Janet, Zijlma, Rolf, Boersma, Hendrikus H., Jorritsma-Smit, Annelies, Hospers, Geke A. P., de Vries, Elisabeth G. E., Lub-de Hooge, Marjolijn N., de Vries, Erik F. J.

“…Background Molecular imaging of immune cells might be a potential tool for response prediction, treatment evaluation and patient selection in inflammatory…”
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Synthesis and Evaluation of [18F]-FEAnGA as a PET Tracer for β-Glucuronidase Activity by Antunes, Inês F, Haisma, Hidde J, Elsinga, Philip H, Dierckx, Rudi A, de Vries, Erik F. J

“…To increase the therapeutic index of chemotherapeutic drugs, prodrugs have been investigated as anticancer agents, as they may present fewer cytotoxic side…”
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Highlight selection of radiochemistry and radiopharmacy developments by editorial board by Alves, Francisco, Antunes, Inês F., Cazzola, Emiliano, Cleeren, Frederik, Cornelissen, Bart, Denkova, Antonia, Engle, Jonathan, Faivre-Chauvet, Alain, Gillings, Nic, Hendrikx, Jeroen J. M. A., Jalilian, Amir R., van der Meulen, Nicholas P., Mikolajczak, Renata, Neels, Oliver C., Pillai, Maroor R. A., Reilly, Raymond, Rubow, Sietske, Seimbille, Yann, Spreckelmeyer, Sarah, Szymanski, Wiktor, Taddei, Carlotta

“…Background The Editorial Board of EJNMMI Radiopharmacy and Chemistry releases a biyearly highlight commentary to update the readership on trends in the field…”
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In Vivo Evaluation of 1-O-(4-(2-Fluoroethyl-Carbamoyloxymethyl)-2-Nitrophenyl)-O-β-D-Glucopyronuronate: A Positron Emission Tomographic Tracer for Imaging β-Glucuronidase Activity in a Tumor/Inflammation Rodent Model by Antunes, Iněs F., Haisma, Hidde J., Elsinga, Philip H., van Waarde, Aren, Willemsen, Antoon T.M., Dierckx, Rudi A., de Vries, Erik F.J.

“…β-Glucuronidase (β-GUS) plays an important role in inflammation and degenerative processes. The enzyme has also been investigated as a target in prodrug…”
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In vivo evaluation of [18 F]FEAnGA-Me: a PET tracer for imaging β-glucuronidase (β-GUS) activity in a tumor/inflammation rodent model by Antunes, Inês F, Haisma, Hidde J, Elsinga, Philip H, Sijbesma, Jurgen W.A, Waarde, Aren van, Willemsen, Antoon T.M, Dierckx, Rudi A, de Vries, Erik F.J

“…Abstract Introduction The PET tracer, 1- O -(4-(2-fluoroethyl-carbamoyloxymethyl)-2-nitrophenyl)- O -β- d -glucopyronuronate ([18 F]FEAnGA), was recently…”
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Synthesis and structural characterization of 1- and 2-substituted indazoles: ester and carboxylic acid derivatives by Teixeira, Fátima C, Ramos, Hélène, Antunes, Inês F, Curto, M João M, Duarte, M Teresa, Bento, Isabel

“…A series of indazoles substituted at the N-1 and N-2 positions with ester-containing side chains -(CH2)(n)CO2R of different lengths (n = 0-6, 9, 10) are…”
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18F-BMS986192 PET Imaging of PD-L1 in Metastatic Melanoma Patients with Brain Metastases Treated with Immune Checkpoint Inhibitors: A Pilot Study by Nienhuis, Pieter H, Antunes, Inês F, Glaudemans, Andor WJM, Jalving, Mathilde, Leung, David, Noordzij, Walter, Slart, Riemer HJA, de Vries, Erik FJ, Hospers, Geke AP

“…Immune checkpoint inhibitors (ICIs) targeting programmed cell death protein-1 (PD-1)/programmed cell death ligand-1 (PD-L1) frequently induces tumor response…”
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18 F-BMS986192 PET Imaging of PD-L1 in Metastatic Melanoma Patients with Brain Metastases Treated with Immune Checkpoint Inhibitors: A Pilot Study by Nienhuis, Pieter H, Antunes, Inês F, Glaudemans, Andor W J M, Jalving, Mathilde, Leung, David, Noordzij, Walter, Slart, Riemer H J A, de Vries, Erik F J, Hospers, Geke A P

“…Immune checkpoint inhibitors (ICIs) targeting programmed cell death protein-1 (PD-1)/programmed cell death ligand-1 (PD-L1) frequently induces tumor response…”
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Synthesis and Evaluation of 18 F-Enzalutamide, a New Radioligand for PET Imaging of Androgen Receptors: A Comparison with 16β- 18 F-Fluoro-5α-Dihydrotestosterone by Antunes, Inês F, Dost, Rutger J, Hoving, Hilde D, van Waarde, Aren, Dierckx, Rudi A J O, Samplonius, Douwe F, Helfrich, Wijnand, Elsinga, Philip H, de Vries, Erik F J, de Jong, Igle J

“…16β- F-fluoro-5α-dihydrotestosterone ( F-FDHT) is a radiopharmaceutical that has been investigated as a diagnostic agent for the assessment of androgen…”
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Mapping Arginase Expression with 18 F-Fluorinated Late-Generation Arginase Inhibitors Derived from Quaternary α-Amino Acids by Clemente, Gonçalo S, Antunes, Inês F, Kurhade, Santosh, van den Berg, Mariska P M, Sijbesma, Jürgen W A, van Waarde, Aren, Buijsman, Rogier C, Willemsen-Seegers, Nicole, Gosens, Reinoud, Meurs, Herman, Dömling, Alexander, Elsinga, Philip H

“…Arginase hydrolyzes L-arginine and influences levels of polyamines and nitric oxide. Arginase overexpression is associated with inflammation and tumorigenesis…”
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Molecular Imaging of PD-L1 Expression and Dynamics with the Adnectin-Based PET Tracer 18 F-BMS-986192 by Stutvoet, Thijs S, van der Veen, Elly L, Kol, Arjan, Antunes, Inês F, de Vries, Erik F J, Hospers, Geke A P, de Vries, Elisabeth G E, de Jong, Steven, Lub-de Hooge, Marjolijn N

“…F-BMS-986192, an adnectin-based human programmed cell death ligand 1 (PD-L1) tracer, was developed to noninvasively determine whole-body PD-L1 expression by…”
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Tumor-specific activation of prodrugs: is there a role for nuclear medicine? by Antunes, Inês F, Haisma, Hidde J, de Vries, Erik F.J

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