Search Results - "Antson, A."

Thermostable virus portal proteins as reprogrammable adapters for solid-state nanopore sensors by Cressiot, Benjamin, Greive, Sandra J., Mojtabavi, Mehrnaz, Antson, Alfred A., Wanunu, Meni

“…Nanopore-based sensors are advancing the sensitivity and selectivity of single-molecule detection in molecular medicine and biotechnology. Current electrical…”
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CryoEM structure of the Nipah virus nucleocapsid assembly by Ker, De-Sheng, Jenkins, Huw T, Greive, Sandra J, Antson, Alfred A

“…Nipah and its close relative Hendra are highly pathogenic zoonotic viruses, storing their ssRNA genome in a helical nucleocapsid assembly formed by the N…”
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Quantitative characterization of protein-protein complexes involved in base excision DNA repair by Moor, Nina A, Vasil'eva, Inna A, Anarbaev, Rashid O, Antson, Alfred A, Lavrik, Olga I

“…Base Excision Repair (BER) efficiently corrects the most common types of DNA damage in mammalian cells. Step-by-step coordination of BER is facilitated by…”
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Cryo-EM structure in situ reveals a molecular switch that safeguards virus against genome loss by Bayfield, Oliver W, Steven, Alasdair C, Antson, Alfred A

“…The portal protein is a key component of many double-stranded DNA viruses, governing capsid assembly and genome packaging. Twelve subunits of the portal…”
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Structure-based discovery of first inhibitors targeting the helicase activity of human PIF1 by Wever, Mark J A, Scommegna, Francesca R, Egea-Rodriguez, Sara, Dehghani-Tafti, Saba, Brandao-Neto, Jose, Poisson, Jean-François, Helfrich, Iris, Antson, Alfred A, Rodeschini, Vincent, Bax, Ben, Roche, Didier, Sanders, Cyril M

“…PIF1 is a conserved helicase and G4 DNA binding and unwinding enzyme, with roles in genome stability. Human PIF1 (hPIF1) is poorly understood, but its…”
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Structural basis of DNA packaging by a ring-type ATPase from an archetypal viral system by Fung, Herman K H, Grimes, Shelley, Huet, Alexis, Duda, Robert L, Chechik, Maria, Gault, Joseph, Robinson, Carol V, Hendrix, Roger W, Jardine, Paul J, Conway, James F, Baumann, Christoph G, Antson, Alfred A

“…Abstract Many essential cellular processes rely on substrate rotation or translocation by a multi-subunit, ring-type NTPase. A large number of double-stranded…”
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Major reorientation of tRNA substrates defines specificity of dihydrouridine synthases by Byrne, Robert T., Jenkins, Huw T., Peters, Daniel T., Whelan, Fiona, Stowell, James, Aziz, Naveed, Kasatsky, Pavel, Rodnina, Marina V., Koonin, Eugene V., Konevega, Andrey L., Antson, Alfred A.

“…The reduction of specific uridines to dihydrouridine is one of the most common modifications in tRNA. Increased levels of the dihydrouridine modification are…”
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Structural framework for DNA translocation via the viral portal protein by Lebedev, Andrey A, Krause, Margret H, Isidro, Anabela L, Vagin, Alexei A, Orlova, Elena V, Turner, Joanne, Dodson, Eleanor J, Tavares, Paulo, Antson, Alfred A

“…Tailed bacteriophages and herpesviruses load their capsids with DNA through a tunnel formed by the portal protein assembly. Here we describe the X‐ray…”
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Diversity and Host Interactions Among Virulent and Temperate Baltic Sea Flavobacterium Phages by Nilsson, Emelie, Bayfield, Oliver W, Lundin, Daniel, Antson, Alfred A, Holmfeldt, Karin

“…Viruses in aquatic environments play a key role in microbial population dynamics and nutrient cycling. In particular, bacteria of the phylum are known to…”
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Jorvik: A membrane-containing phage that will likely found a new family within Vinavirales by Bárdy, Pavol, MacDonald, Conor I.W., Pantůček, Roman, Antson, Alfred A., Fogg, Paul C.M.

“…Although membrane-containing dsDNA bacterial viruses are some of the most prevalent predators in aquatic environments, we know little about how they function…”
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Structure of the trp RNA-binding attenuation protein, TRAP, bound to RNA by Antson, Alfred A, Dodson, Eleanor J, Dodson, Guy, Greaves, Richard B, Chen, Xiao-ping, Gollnick, Paul

“…The trp RNA-binding attenuation protein (TRAP) regulates expression of the tryptophan biosynthetic genes of several bacilli by binding single-stranded RNA. The…”
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Structural basis for DNA recognition and loading into a viral packaging motor by Büttner, Carina R., Chechik, Maria, Ortiz-Lombardía, Miguel, Smits, Callum, Ebong, Ima-Obong, Chechik, Victor, Jeschke, Gunnar, Dykeman, Eric, Benini, Stefano, Robinson, Carol V., Alonso, Juan C., Antson, Alfred A.

“…Genome packaging into preformed viral procapsids is driven by powerful molecular motors. The small terminase protein is essential for the initial recognition…”
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Crystal Structure of Bacillus anthracis ThiI, a tRNA-modifying Enzyme Containing the Predicted RNA-binding THUMP Domain by Waterman, David G., Ortiz-Lombardía, Miguel, Fogg, Mark J., Koonin, Eugene V., Antson, Alfred A.

“…ThiI is an enzyme responsible for the formation of the modified base S 4U (4-thiouridine) found at position 8 in some prokaryotic tRNAs. This base acts as a…”
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Trp RNA-binding attenuation protein: modifying symmetry and stability of a circular oligomer by Bayfield, Oliver W, Chen, Chao-Sheng, Patterson, Andrea R, Luan, Weisha, Smits, Callum, Gollnick, Paul, Antson, Alfred A

“…Subunit number is amongst the most important structural parameters that determine size, symmetry and geometry of a circular protein oligomer. The L-tryptophan…”
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How to change the oligomeric state of a circular protein assembly: switch from 11-subunit to 12-subunit TRAP suggests a general mechanism by Chen, Chao-Sheng, Smits, Callum, Dodson, Guy G, Shevtsov, Mikhail B, Merlino, Natalie, Gollnick, Paul, Antson, Alfred A

“…Many critical cellular functions are performed by multisubunit circular protein oligomers whose internal geometry has evolved to meet functional requirements…”
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Structural Rearrangements between Portal Protein Subunits Are Essential for Viral DNA Translocation by Cuervo, Ana, Vaney, Marie-Christine, Antson, Alfred A., Tavares, Paulo, Oliveira, Leonor

“…Transport of DNA into preformed procapsids is a general strategy for genome packing inside virus particles. In most viruses, this task is accomplished by a…”
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High-Voltage Biomolecular Sensing Using a Bacteriophage Portal Protein Covalently Immobilized within a Solid-State Nanopore by Mojtabavi, Mehrnaz, Greive, Sandra J., Antson, Alfred A., Wanunu, Meni

“…The application of nanopores as label-free, single-molecule biosensors for electrical or optical probing of structural features in biomolecules has been widely…”
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Broad and strong memory CD4+ and CD8+ T cells induced by SARS-CoV-2 in UK convalescent individuals following COVID-19 by Peng, Yanchun, Mentzer, Alexander J., Liu, Guihai, Yao, Xuan, Yin, Zixi, Dong, Danning, Dejnirattisai, Wanwisa, Rostron, Timothy, Supasa, Piyada, Liu, Chang, López-Camacho, César, Slon-Campos, Jose, Zhao, Yuguang, Stuart, David I., Paesen, Guido C., Grimes, Jonathan M., Antson, Alfred A., Bayfield, Oliver W., Hawkins, Dorothy E. D. P., Ker, De-Sheng, Wang, Beibei, Turtle, Lance, Subramaniam, Krishanthi, Thomson, Paul, Zhang, Ping, Dold, Christina, Ratcliff, Jeremy, Simmonds, Peter, de Silva, Thushan, Sopp, Paul, Wellington, Dannielle, Rajapaksa, Ushani, Chen, Yi-Ling, Salio, Mariolina, Napolitani, Giorgio, Paes, Wayne, Borrow, Persephone, Kessler, Benedikt M., Fry, Jeremy W., Schwabe, Nikolai F., Semple, Malcolm G., Baillie, J. Kenneth, Moore, Shona C., Openshaw, Peter J. M., Ansari, M. Azim, Dunachie, Susanna, Barnes, Eleanor, Frater, John, Kerr, Georgina, Goulder, Philip, Lockett, Teresa, Levin, Robert, Zhang, Yonghong, Jing, Ronghua, Ho, Ling-Pei, Cornall, Richard J., Conlon, Christopher P., Klenerman, Paul, Screaton, Gavin R., Mongkolsapaya, Juthathip, McMichael, Andrew, Knight, Julian C., Ogg, Graham, Dong, Tao

“…The development of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccines and therapeutics will depend on understanding viral immunity. We…”
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Insights into the Catalytic Mechanism of Tyrosine Phenol-lyase from X-ray Structures of Quinonoid Intermediates by Milić, Dalibor, Demidkina, Tatyana V., Faleev, Nicolai G., Matković-Čalogović, Dubravka, Antson, Alfred A.

“…Amino acid transformations catalyzed by a number of pyridoxal 5′-phosphate (PLP)-dependent enzymes involve abstraction of the Cα proton from an external…”
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The crystal structure of YloQ, a circularly permuted GTPase essential for Bacillus subtilis viability by Levdikov, Vladimir M, Blagova, Elena V, Brannigan, James A, Cladière, Lionel, Antson, Alfred A, Isupov, Michail N, Séror, Simone J, Wilkinson, Anthony J

“…yloQ is one of 11 essential genes in Bacillus subtilis with unknown roles in the physiology of the cell. It encodes a polypeptide of 298 residues with motifs…”
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