Search Results - "Antoun, Elie"

Maternal dysglycaemia, changes in the infant's epigenome modified with a diet and physical activity intervention in pregnancy: Secondary analysis of a randomised control trial by Antoun, Elie, Kitaba, Negusse T, Titcombe, Philip, Dalrymple, Kathryn V, Garratt, Emma S, Barton, Sheila J, Murray, Robert, Seed, Paul T, Holbrook, Joanna D, Kobor, Michael S, Lin, David Ts, MacIsaac, Julia L, Burdge, Graham C, White, Sara L, Poston, Lucilla, Godfrey, Keith M, Lillycrop, Karen A

“…Higher maternal plasma glucose (PG) concentrations, even below gestational diabetes mellitus (GDM) thresholds, are associated with adverse offspring outcomes,…”
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Adiposity is associated with widespread transcriptional changes and downregulation of longevity pathways in aged skeletal muscle by Burton, Mark A., Antoun, Elie, Garratt, Emma S., Westbury, Leo, Baczynska, Alica, Dennison, Elaine M., Harvey, Nicholas C., Cooper, Cyrus, Patel, Harnish P., Godfrey, Keith M., Lillycrop, Karen A.

“…Background Amongst healthy older people, a number of correlates of impaired skeletal muscle mass and function have been defined. Although the prevalence of…”
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Human non-CpG methylation patterns display both tissue-specific and inter-individual differences suggestive of underlying function by Titcombe, Philip, Murray, Robert, Hewitt, Matthew, Antoun, Elie, Cooper, Cyrus, Inskip, Hazel M, Holbrook, Joanna D, Godfrey, Keith M, Lillycrop, Karen, Hanson, Mark, Barton, Sheila J

“…DNA methylation (DNAm) in mammals is mostly examined within the context of CpG dinucleotides. Non-CpG DNAm is also widespread across the human genome, but the…”
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Modification of subcutaneous white adipose tissue inflammation by omega-3 fatty acids is limited in human obesity-a double blind, randomised clinical trial by Fisk, Helena L, Childs, Caroline E, Miles, Elizabeth A, Ayres, Robert, Noakes, Paul S, Paras-Chavez, Carolina, Kuda, Ondrej, Kopecký, Jan, Antoun, Elie, Lillycrop, Karen A, Calder, Philip C

“…Obesity is associated with enhanced inflammation. However, investigation in human subcutaneous white adipose tissue (scWAT) is limited and the mechanisms by…”
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Dysregulation of Subcutaneous White Adipose Tissue Inflammatory Environment Modelling in Non-Insulin Resistant Obesity and Responses to Omega-3 Fatty Acids – A Double Blind, Randomised Clinical Trial by Fisk, Helena L., Childs, Caroline E., Miles, Elizabeth A., Ayres, Robert, Noakes, Paul S., Paras-Chavez, Carolina, Antoun, Elie, Lillycrop, Karen A., Calder, Philip C.

“…Background Obesity is associated with enhanced lipid accumulation and the expansion of adipose tissue accompanied by hypoxia and inflammatory signalling…”
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Folic Acid Induces Intake-Related Changes in the Mammary Tissue Transcriptome of C57BL/6 Mice by Burton, Mark A, Antoun, Elie, Penailillo, Reyna S, Burdge, Graham C, Lillycrop, Karen A

“…Folic acid (FA) intake has been associated with increased breast cancer risk in some studies. Although underlying mechanisms are unknown, epigenetic…”
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Epigenome‐wide association study of sarcopenia: findings from the Hertfordshire Sarcopenia Study (HSS) by Antoun, Elie, Garratt, Emma S., Taddei, Andrea, Burton, Mark A., Barton, Sheila J., Titcombe, Phil, Westbury, Leo D., Baczynska, Alicia, Migliavacca, Eugenia, Feige, Jerome N., Sydall, Holly E., Dennison, Elaine, Dodds, Richard, Roberts, Helen C., Richardson, Peter, Sayer, Avan A., Shaw, Sarah, Cooper, Cyrus, Holbrook, Joanna D., Patel, Harnish P., Godfrey, Keith M., Lillycrop, Karen A.

“…Background Sarcopenia is the age‐related loss of muscle mass, strength, and function. Epigenetic processes such as DNA methylation, which integrate both…”
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DNA methylation of insulin signaling pathways is associated with HOMA2-IR in primary myoblasts from older adults by Burton, Mark A, Garratt, Emma S, Hewitt, Matthew O, Sharkh, Hanan Y, Antoun, Elie, Westbury, Leo D, Dennison, Elaine M, Harvey, Nicholas C, Cooper, Cyrus, MacIsaac, Julia L, Kobor, Michael S, Patel, Harnish P, Godfrey, Keith M, Lillycrop, Karen A

“…While ageing is associated with increased insulin resistance (IR), the molecular mechanisms underlying increased IR in the muscle, the primary organ for…”
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SARS-CoV-2 mutations affect antigen processing by the proteasome to alter CD8+ T cell responses by Wellington, Dannielle, Yin, Zixi, Yu, Zhanru, Heilig, Raphael, Davis, Simon, Fischer, Roman, Felce, Suet Ling, Antoun, Elie, Hublitz, Philip, Beveridge, Ryan, Dong, Danning, Liu, Guihai, Yao, Xuan, Peng, Yanchun, Kessler, Benedikt M., Dong, Tao

“…Mutations within viral epitopes can result in escape from T cells, but the contribution of mutations in flanking regions of epitopes in SARS-CoV-2 has not been…”
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Altered H19/miR‐675 expression in skeletal muscle is associated with low muscle mass in community‐dwelling older adults by Antoun, Elie, Migliavacca, Eugenia, Garratt, Emma S, Barton, Sheila J, Titcombe, Phil, Westbury, Leo D, Baczynska, Alica, Dodds, Richards, Roberts, Helen C, Sayer, Avan A, Shaw, Sarah, Syddall, H.E., Sheppard, Allan, McFarlane, Craig, Karnani, Neerja, Forrester, Terrence, Cooper, Cyrus, Feige, Jerome N, Patel, Harnish P, Godfrey, Keith M, Lillycrop, Karen A

“…Background Despite increasing knowledge of the pathogenesis of muscle ageing, the molecular mechanisms are poorly understood. Based on an expression analysis…”
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Vaccine-induced CD8+ T cells are key to protection from SARS-CoV-2 by Antoun, Elie, Peng, Yanchun, Dong, Tao

“…After vaccination, spike-specific CD8 + T cells play an important part in the immediate immune response to breakthrough SARS-CoV-2 infection, whereas the B…”
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Fluoroquinolone-Resistant Escherichia coli Infections After Transrectal Biopsy of the Prostate in the Veterans Affairs Healthcare System by Saade, Elie A, Suwantarat, Nuntra, Zabarsky, Trina F, Wilson, Brigid, Donskey, Curtis J

“…Recent reports suggest that infections due to fluoroquinolone-resistant are an increasingly common complication of transrectal biopsy of the prostate (TBP) in…”
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The serum small non‐coding RNA (SncRNA) landscape as a molecular biomarker of age associated muscle dysregulation and insulin resistance in older adults by Burton, Mark A., Antoun, Elie, Garratt, Emma S., Westbury, Leo, Dennison, Elaine M., Harvey, Nicholas C., Cooper, Cyrus, Patel, Harnish P., Godfrey, Keith M., Lillycrop, Karen A.

“…Small noncoding RNAs (sncRNAs) are implicated in age‐associated pathologies, including sarcopenia and insulin resistance (IR). As potential circulating…”
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Influence of Maternal Lifestyle and Diet on Perinatal DNA Methylation Signatures Associated With Childhood Arterial Stiffness at 8 to 9 Years by Murray, Robert, Kitaba, Negusse, Antoun, Elie, Titcombe, Philip, Barton, Sheila, Cooper, Cyrus, Inskip, Hazel M., Burdge, Graham C., Mahon, Pamela A., Deanfield, John, Halcox, Julian P., Ellins, Elizabeth A., Bryant, Jennifer, Peebles, Charles, Lillycrop, Karen, Godfrey, Keith M., Hanson, Mark A.

“…Increases in aortic pulse wave velocity, a measure of arterial stiffness, can lead to elevated systolic blood pressure and increased cardiac afterload in…”
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Unconventional human CD61 pairing with CD103 promotes TCR signaling and antigen-specific T cell cytotoxicity by Hamid, Megat H. B. A., Cespedes, Pablo F., Jin, Chen, Chen, Ji-Li, Gileadi, Uzi, Antoun, Elie, Liang, Zhu, Gao, Fei, Teague, Renuka, Manoharan, Nikita, Maldonado-Perez, David, Khalid-Alham, Nasullah, Cerundolo, Lucia, Ciaoca, Raul, Hester, Svenja S., Pinto-Fernández, Adán, Draganov, Simeon D., Vendrell, Iolanda, Liu, Guihai, Yao, Xuan, Kvalvaag, Audun, Dominey-Foy, Delaney C. C., Nanayakkara, Charunya, Kanellakis, Nikolaos, Chen, Yi-Ling, Waugh, Craig, Clark, Sally-Ann, Clark, Kevin, Sopp, Paul, Rahman, Najib M., Verrill, Clare, Kessler, Benedikt M., Ogg, Graham, Fernandes, Ricardo A., Fisher, Roman, Peng, Yanchun, Dustin, Michael L., Dong, Tao

“…Cancer remains one of the leading causes of mortality worldwide, leading to increased interest in utilizing immunotherapy strategies for better cancer…”
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Influence of Maternal Lifestyle and Diet on Perinatal DNA Methylation Signatures Associated With Childhood Arterial Stiffness at 8 to 9 Years by Murray, Robert, Kitaba, Negusse, Antoun, Elie, Titcombe, Philip, Barton, Sheila, Cooper, Cyrus, Inskip, Hazel M., Burdge, Graham C., Mahon, Pamela A., Deanfield, John, Halcox, Julian P., Ellins, Elizabeth A., Bryant, Jennifer, Peebles, Charles, Lillycrop, Karen, Godfrey, Keith M., Hanson, Mark A.

“…Increases in aortic pulse wave velocity, a measure of arterial stiffness, can lead to elevated systolic blood pressure and increased cardiac afterload in…”
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DNA methylation of Th2 lineage determination genes at birth is associated with allergic outcomes in childhood by Barton, S. J., Ngo, S., Costello, P., Garratt, E., El‐Heis, S., Antoun, E., Clarke‐Harris, R., Murray, R., Bhatt, T., Burdge, G., Cooper, C., Inskip, H., van der Beek, E. M., Sheppard, A., Godfrey, K. M., Lillycrop, K. A.

“…Summary Background There is now increasing evidence that asthma and atopy originate in part in utero, with disease risk being associated with the altered…”
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Folate and vitamin B12 status: associations with maternal glucose and neonatal DNA methylation sites related to dysglycaemia, in pregnant women with obesity by van Weelden, Wenneke, Seed, Paul T, Antoun, Elie, Godfrey, Keith M, Kitaba, Negusse T, Lillycrop, Karen A, Dalrymple, Kathryn V, Sobczyńska-Malefora, Agata, Painter, Rebecca C, Poston, Lucilla, White, Sara L, Flynn, Angela C

“…Recent studies implicate maternal gestational diabetes mellitus (GDM) in differential methylation of infant DNA. Folate and vitamin B12 play a role in DNA…”
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Childhood DNA methylation as a marker of early life rapid weight gain and subsequent overweight by Robinson, N, Brown, H, Antoun, Elie, Godfrey, Keith M, Hanson, Mark A, Lillycrop, Karen A, Crozier, Sarah R, Murray, Robert, Pearce, M S, Relton, C L, Albani, V, McKay, J A

“…High early postnatal weight gain has been associated with childhood adiposity; however, the mechanism remains unknown. DNA methylation is a hypothesised…”
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DNA methylation signatures associated with cardiometabolic risk factors in children from India and The Gambia: results from the EMPHASIS study by Antoun, Elie, Issarapu, Prachand, di Gravio, Chiara, Shrestha, Smeeta, Betts, Modupeh, Saffari, Ayden, Sahariah, Sirazul A, Sankareswaran, Alagu, Arumalla, Manisha, Prentice, Andrew M, Fall, Caroline H D, Silver, Matt J, Chandak, Giriraj R, Lillycrop, Karen A

“…The prevalence of cardiometabolic disease (CMD) is rising globally, with environmentally induced epigenetic changes suggested to play a role. Few studies have…”
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