Search Results - "Antony, Justin"

Uridine Depletion and Chemical Modification Increase Cas9 mRNA Activity and Reduce Immunogenicity without HPLC Purification by Vaidyanathan, Sriram, Azizian, Krist T., Haque, A.K.M. Ashiqul, Henderson, Jordana M., Hendel, Ayal, Shore, Sabrina, Antony, Justin S., Hogrefe, Richard I., Kormann, Michael S.D., Porteus, Matthew H., McCaffrey, Anton P.

“…The Cas9/guide RNA (Cas9/gRNA) system is commonly used for genome editing. mRNA expressing Cas9 can induce innate immune responses, reducing Cas9 expression…”
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The synergistic anti-Warburg efficacy of temozolomide, metformin and epigallocatechin gallate in glioblastoma by Kuduvalli, Shreyas S., Senthilathiban, Daisy Precilla, Biswas, Indrani, Antony, Justin S., Subramani, Madhu, Anitha, T.S.

“…An important hallmark of glioblastoma aggressiveness is its altered metabolism of glucose. This metabolic shift wherein the tumor cells employ aerobic…”
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Gene therapy in pediatrics – Clinical studies and approved drugs (as of 2023) by Mohammadian Gol, Tahereh, Zahedipour, Fatemeh, Trosien, Paul, Ureña-Bailén, Guillermo, Kim, Miso, Antony, Justin S., Mezger, Markus

“…Gene therapy in pediatrics represents a cutting-edge therapeutic strategy for treating a range of genetic disorders that manifest in childhood. Gene therapy…”
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Transcriptomic profile of cystic fibrosis patients identifies type I interferon response and ribosomal stalk proteins as potential modifiers of disease severity by Kormann, Michael S D, Dewerth, Alexander, Eichner, Felizitas, Baskaran, Praveen, Hector, Andreas, Regamey, Nicolas, Hartl, Dominik, Handgretinger, Rupert, Antony, Justin S

“…Cystic Fibrosis (CF) is the most common monogenic disease among people of Western European descent and caused by mutations in the CFTR gene. However, the…”
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Human pluripotent stem cell-derived acinar/ductal organoids generate human pancreas upon orthotopic transplantation and allow disease modelling by Hohwieler, Meike, Illing, Anett, Hermann, Patrick C, Mayer, Tobias, Stockmann, Marianne, Perkhofer, Lukas, Eiseler, Tim, Antony, Justin S, Müller, Martin, Renz, Susanne, Kuo, Chao-Chung, Lin, Qiong, Sendler, Matthias, Breunig, Markus, Kleiderman, Susanne M, Lechel, André, Zenker, Martin, Leichsenring, Michael, Rosendahl, Jonas, Zenke, Martin, Sainz, Jr, Bruno, Mayerle, Julia, Costa, Ivan G, Seufferlein, Thomas, Kormann, Michael, Wagner, Martin, Liebau, Stefan, Kleger, Alexander

“…The generation of acinar and ductal cells from human pluripotent stem cells (PSCs) is a poorly studied process, although various diseases arise from this…”
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Preclinical Evaluation of CRISPR-Edited CAR-NK-92 Cells for Off-the-Shelf Treatment of AML and B-ALL by Ureña-Bailén, Guillermo, Dobrowolski, Jérôme-Maurice, Hou, Yujuan, Dirlam, Alicia, Roig-Merino, Alicia, Schleicher, Sabine, Atar, Daniel, Seitz, Christian, Feucht, Judith, Antony, Justin S., Mohammadian Gol, Tahereh, Handgretinger, Rupert, Mezger, Markus

“…Acute myeloid leukemia (AML) and B-cell acute lymphocytic leukemia (B-ALL) are severe blood malignancies affecting both adults and children. Chimeric antigen…”
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CRISPR/Cas9-modified hematopoietic stem cells—present and future perspectives for stem cell transplantation by Daniel-Moreno, Alberto, Lamsfus-Calle, Andrés, Raju, Janani, Antony, Justin S., Handgretinger, Rupert, Mezger, Markus

“…Allogeneic hematopoietic stem cell transplantation (HSCT) is a standard therapeutic intervention for hematological malignancies and several monogenic diseases…”
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Ceftriaxone induces glial EAAT‐2 promotor region via NF‐kB conformational changes: An interaction analysis using HADDOCK by Rao, Gaddam Narasimha, Jupudi, Srikanth, Pant, Pradeep, Palathoti, Nagarjuna, Rajagopal, Kalirajan, Govindasamy, Rathika, Justin, Antony

“…Excitotoxicity, depletion of energy metabolites, and ionic imbalance are the major factors involved in neurodegeneration mediated through excitatory amino acid…”
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Investigation of microplastic contamination in the sediments of Noyyal River- Southern India by Ayyamperumal, Ramamoorthy, Huang, Xiaozhong, Li, Fengjie, Chengjun, Zhang, Chellaiah, Gajendran, Gopalakrishnan, Gnanachandrasamy, Senapathi, Venkatramanan, Perumal, Rajkumar, Antony, Justin K

“…Microplastics (MPs) have received widespread attention as an emerging environmental pollutant. They are ubiquitous in the freshwater system and have caused a…”
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Chemically modified hCFTR mRNAs recuperate lung function in a mouse model of cystic fibrosis by Haque, A. K. M. Ashiqul, Dewerth, Alexander, Antony, Justin S., Riethmüller, Joachim, Schweizer, Georg R., Weinmann, Petra, Latifi, Ngadhnjim, Yasar, Hanzey, Pedemonte, Nicoletta, Sondo, Elvira, Weidensee, Brian, Ralhan, Anjali, Laval, Julie, Schlegel, Patrick, Seitz, Christian, Loretz, Brigitta, Lehr, Claus-Michael, Handgretinger, Rupert, Kormann, Michael S. D.

“…Gene therapy has always been a promising therapeutic approach for Cystic Fibrosis (CF). However, numerous trials using DNA or viral vectors encoding the…”
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Comparative targeting analysis of KLF1, BCL11A, and HBG1/2 in CD34+ HSPCs by CRISPR/Cas9 for the induction of fetal hemoglobin by Lamsfus-Calle, Andrés, Daniel-Moreno, Alberto, Antony, Justin S., Epting, Thomas, Heumos, Lukas, Baskaran, Praveen, Admard, Jakob, Casadei, Nicolas, Latifi, Ngadhnjim, Siegmund, Darina M., Kormann, Michael S. D., Handgretinger, Rupert, Mezger, Markus

“…β-hemoglobinopathies are caused by abnormal or absent production of hemoglobin in the blood due to mutations in the β-globin gene ( HBB ). Imbalanced…”
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CRISPR-Cas9-Based Gene Knockout of Immune Checkpoints in Expanded NK Cells by Mohammadian Gol, Tahereh, Kim, Miso, Sinn, Ralph, Ureña-Bailén, Guillermo, Stegmeyer, Sarah, Gratz, Paul Gerhard, Zahedipour, Fatemeh, Roig-Merino, Alicia, Antony, Justin S, Mezger, Markus

“…Natural killer (NK) cell immunotherapy has emerged as a novel treatment modality for various cancer types, including leukemia. The modulation of inhibitory…”
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Hematopoietic stem cell gene therapy: The optimal use of lentivirus and gene editing approaches by Lamsfus-Calle, Andrés, Daniel-Moreno, Alberto, Ureña-Bailén, Guillermo, Raju, Janani, Antony, Justin S., Handgretinger, Rupert, Mezger, Markus

“…Due to pioneering in vitro investigations on gene modification, gene engineering platforms have incredibly improved to a safer and more powerful tool for the…”
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Accelerated generation of gene‐engineered monoclonal CHO cell lines using FluidFM nanoinjection and CRISPR/Cas9 by Antony, Justin S., Herranz, Anabel Migenda, Mohammadian Gol, Tahereh, Mailand, Susanne, Monnier, Paul, Rottenberger, Jennifer, Roig‐Merino, Alicia, Keller, Bettina, Gowin, Claudia, Milla, Maria, Beyer, Tobias A., Mezger, Markus

“…Chinese hamster ovary (CHO) cells are the commonly used mammalian host system to manufacture recombinant proteins including monoclonal antibodies. However…”
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Association of Ficolin-2 Serum Levels and FCN2 Genetic Variants with Indian Visceral Leishmaniasis by Mishra, Anshuman, Antony, Justin S, Sundaravadivel, Pandarisamy, Tong, Hoang Van, Meyer, Christian G, Jalli, Reshma D, Velavan, Thirumalaisamy P, Thangaraj, Kumarasamy

“…Visceral leishmaniasis (VL), one of the neglected tropical diseases, is endemic in the Indian subcontinent. Ficolins are circulating serum proteins of the…”
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Generation of a heterozygous and a homozygous CSF1R knockout line from iPSC using CRISPR/Cas9 by Schmitz, Anne S., Korneck, Milena, Raju, Janani, Lamsfus-Calle, Andrés, Daniel-Moreno, Alberto, Antony, Justin S., Mezger, Markus, Schöls, Ludger, Hauser, Stefan, Hayer, Stefanie N.

“…Mutations in Colony-stimulating factor 1 receptor (CSF1R) lead to CSF1R-related leukoencephalopathy, also known as Adult-onset leukoencephalopathy with axonal…”
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Lectin complement protein Collectin 11 (CL-K1) and susceptibility to urinary schistosomiasis by Antony, Justin S, Ojurongbe, Olusola, Kremsner, Peter G, Velavan, Thirumalaisamy P

“…Urinary Schistosomiasis is a neglected tropical disease endemic in many sub Saharan -African countries. Collectin Kidney 1 (CL-K1, encoded by COLEC11 on…”
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CRISPR/Cas9 technology: towards a new generation of improved CAR-T cells for anticancer therapies by Ureña-Bailén, Guillermo, Lamsfus-Calle, Andrés, Daniel-Moreno, Alberto, Raju, Janani, Schlegel, Patrick, Seitz, Christian, Atar, Daniel, Antony, Justin S, Handgretinger, Rupert, Mezger, Markus

“…Chimeric antigen receptor (CAR)-modified T cells have raised among other immunotherapies for cancer treatment, being implemented against B-cell malignancies…”
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Local application of engineered insulin-like growth factor I mRNA demonstrates regenerative therapeutic potential in vivo by Antony, Justin S., Birrer, Pascale, Bohnert, Claudia, Zimmerli, Sina, Hillmann, Petra, Schaffhauser, Hervé, Hoeflich, Christine, Hoeflich, Andreas, Khairallah, Ramzi, Satoh, Andreas T., Kappeler, Isabelle, Ferreira, Isabel, Zuideveld, Klaas P., Metzger, Friedrich

“…Insulin-like growth factor I (IGF-I) is a growth-promoting anabolic hormone that fosters cell growth and tissue homeostasis. IGF-I deficiency is associated…”
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A combination of metformin and epigallocatechin gallate potentiates glioma chemotherapy in vivo by Kuduvalli, Shreyas S, Daisy, Precilla S, Vaithy, Anandraj, Purushothaman, Mugilarasi, Ramachandran Muralidharan, Arumugam, Agiesh, Kumar B, Mezger, Markus, Antony, Justin S, Subramani, Madhu, Dubashi, Biswajit, Biswas, Indrani, Guruprasad, K P, Anitha, T S

“…Glioma is the most devastating high-grade tumor of the central nervous system, with dismal prognosis. Existing treatment modality does not provide substantial…”
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