Search Results - "Antonson, P"

Generation of an all-exon Esr2 deleted mouse line: Effects on fertility by Antonson, Per, Apolinário, Leticia Montanholi, Shamekh, Mohamed M., Humire, Patricia, Poutanen, Matti, Ohlsson, Claes, Nalvarte, Ivan, Gustafsson, Jan-Åke

“…Estrogen receptor beta (ERβ), encoded by the Esr2 gene, is one of two nuclear receptors that mediate the functions of the steroid hormone estradiol. The…”
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Estrogen receptor-α in osteocytes is important for trabecular bone formation in male mice by Windahl, Sara H., Börjesson, Anna E., Farman, Helen H., Engdahl, Cecilia, Movérare-Skrtic, Sofia, Sjögren, Klara, Lagerquist, Marie K., Kindblom, Jenny M., Koskela, Antti, Tuukkanen, Juha, Pajevic, Paola Divieti, Feng, Jian Q., Dahlman-Wright, Karin, Antonson, Per, Gustafsson, Jan-Åke, Ohlsson, Claes

“…The bone-sparing effect of estrogen in both males and females is primarily mediated via estrogen receptor-α (ERα), encoded by the Esr1 gene. ERα in osteoclasts…”
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Generation of ERα-floxed and knockout mice using the Cre/LoxP system by Antonson, P., Omoto, Y., Humire, P., Gustafsson, J.-Å.

“…► ERα floxed and knockout mice were generated. ► Disruption of the ERα gene results in sterility in both male and female mice. ► ERα−/− mice have ovaries with…”
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Identification of proteins highly expressed in uterine fluid from mice with hydrometra by Antonson, Per, Nalvarte, Ivan, Varshney, Mukesh, Xu, Li, Windahl, Sara H., Humire, Patricia, Ohlsson, Claes, Gustafsson, Jan-Åke, Dahlman-Wright, Karin

“…Estrogen receptor alpha (ERα) is an important regulator of the estrous cycle and mice with global ERα deletion, as well as some conditional knockout mouse…”
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aP2-Cre-mediated inactivation of estrogen receptor alpha causes hydrometra by Antonson, Per, Matic, Marko, Portwood, Neil, Kuiper, Raoul V, Bryzgalova, Galyna, Gao, Hui, Windahl, Sara H, Humire, Patricia, Ohlsson, Claes, Berggren, Per-Olof, Gustafsson, Jan-Åke, Dahlman-Wright, Karin

“…In this study we describe the reproductive phenotypes of a novel mouse model in which Cre-mediated deletion of ERα is regulated by the aP2 (fatty acid binding…”
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Molecular Cloning, Sequence, and Expression Patterns of the Human Gene Encoding CCAAT/Enhancer Binding Protein α (C/EBPα) by Antonson, P., Xanthopoulos, K.G.

“…The human gene encoding the transcription factor C/EBPα was isolated from an umbilical cord genomic library screened by low stringency hybridization. Two…”
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ERβ in Granulosa Cell Tumors and Its Clinical Potential by Birgersson, Madeleine, Indukuri, Rajitha, Antonson, Per, Nalvarte, Ivan, Archer, Amena, Williams, Cecilia

“…Abstract Granulosa cell tumors (GCTs) are rare ovarian tumors comprising an adult and a juvenile subtype. They have a generally good prognosis, but the…”
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Myeloid LXR (Liver X Receptor) Deficiency Induces Inflammatory Gene Expression in Foamy Macrophages and Accelerates Atherosclerosis by Endo-Umeda, Kaori, Kim, Eunyoung, Thomas, David G., Liu, Wenli, Dou, Huijuan, Yalcinkaya, Mustafa, Abramowicz, Sandra, Xiao, Tong, Antonson, Per, Gustafsson, Jan-Åke, Makishima, Makoto, Reilly, Muredach P., Wang, Nan, Tall, Alan R.

“…Cholesterol loaded macrophage foam cells are a prominent feature of atherosclerotic plaques. Single-cell RNA sequencing has identified foam cells as TREM2…”
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Molecular and functional heterogeneity of IL-10-producing CD4+ T cells by Brockmann, Leonie, Soukou, Shiwa, Steglich, Babett, Czarnewski, Paulo, Zhao, Lilan, Wende, Sandra, Bedke, Tanja, Ergen, Can, Manthey, Carolin, Agalioti, Theodora, Geffken, Maria, Seiz, Oliver, Parigi, Sara M., Sorini, Chiara, Geginat, Jens, Fujio, Keishi, Jacobs, Thomas, Roesch, Thomas, Izbicki, Jacob R., Lohse, Ansgar W., Flavell, Richard A., Krebs, Christian, Gustafsson, Jan-Ake, Antonson, Per, Roncarolo, Maria Grazia, Villablanca, Eduardo J., Gagliani, Nicola, Huber, Samuel

“…IL-10 is a prototypical anti-inflammatory cytokine, which is fundamental to the maintenance of immune homeostasis, especially in the intestine. There is an…”
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Ventral prostate and mammary gland phenotype in mice with complete deletion of the ERβ gene by Warner, Margaret, Wu, Wan-fu, Montanholi, Leticia, Nalvarte, Ivan, Antonson, Per, Gustafsson, Jan-Ake

“…Disagreements about the phenotype of estrogen receptor β (ERβ) knockout mouse, created by removing the DNA-binding domain of the ERβ gene or interruption of…”
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Genomics of sex hormone receptor signaling in hepatic sexual dimorphism by Zheng, Daoshan, Wang, Xiao, Antonson, Per, Gustafsson, Jan-Åke, Li, Zhaoyu

“…The liver plays a crucial role in a variety of physiological processes. Sexual dimorphism is markedly defined in liver disorders, such as fatty liver diseases…”
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LXR Suppresses Inflammatory Gene Expression and Neutrophil Migration through cis-Repression and Cholesterol Efflux by Thomas, David G., Doran, Amanda C., Fotakis, Panagiotis, Westerterp, Marit, Antonson, Per, Jiang, Hui, Jiang, Xian-Cheng, Gustafsson, Jan-Åke, Tabas, Ira, Tall, Alan R.

“…The activation of liver X receptor (LXR) promotes cholesterol efflux and repression of inflammatory genes with anti-atherogenic consequences. The mechanisms…”
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Loss of liver X receptor β in astrocytes leads to anxiety-like behaviors via regulating synaptic transmission in the medial prefrontal cortex in mice by Li, Xin, Zhong, Hongyu, Wang, Zhongke, Xiao, Rui, Antonson, Per, Liu, Tianyao, Wu, Chuan, Zou, Jiao, Wang, Lian, Nalvarte, Ivan, Xu, Haiwei, Warner, Margaret, Gustafsson, Jan-Ake, Fan, Xiaotang

“…Astrocytes are integral components of synaptic transmission, and their dysfunction leads to neuropsychiatric disorders such as anxiety and depression. Liver X…”
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Role of estrogen receptor beta in neural differentiation of mouse embryonic stem cells by Varshney, Mukesh K., Inzunza, José, Lupu, Diana, Ganapathy, Vaidheeswaran, Antonson, Per, Rüegg, Joëlle, Nalvarte, Ivan, Gustafsson, Jan-Åke

“…The ability to propagate mature cells and tissue from pluripotent stem cells offers enormous promise for treating many diseases, including neurodegenerative…”
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Estrogen receptor β, a regulator of androgen receptor signaling in the mouse ventral prostate by Wu, Wan-fu, Maneix, Laure, Insunza, Jose, Nalvarte, Ivan, Antonson, Per, Kere, Juha, Yu, Nancy Yiu-Lin, Tohonen, Virpi, Katayama, Shintaro, Einarsdottir, Elisabet, Krjutskov, Kaarel, Dai, Yu-bing, Huang, Bo, Su, Wen, Warner, Margaret, Gustafsson, Jan-Åke

“…As estrogen receptor β−/− (ERβ−/−) mice age, the ventral prostate (VP) develops increased numbers of hyperplastic, fibroplastic lesions and inflammatory cells…”
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Loss of ERβ in Aging LXRαβ Knockout Mice Leads to Colitis by Song, Xiaoyu, Wu, Wanfu, Dai, Yubing, Warner, Margaret, Nalvarte, Ivan, Antonson, Per, Varshney, Mukesh, Gustafsson, Jan-Åke

“…Liver X receptors (LXRα and LXRβ) are oxysterol-activated nuclear receptors that play key roles in cholesterol homeostasis, the central nervous system, and the…”
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Estrogen Signalling and the Metabolic Syndrome: Targeting the Hepatic Estrogen Receptor Alpha Action (vol 8, e57458, 2013) by Matic, M, Bryzgalova, G, Gao, H, Antonson, P, Humire, P, Omoto, Y, Portwood, N, Pramfalk, C, Efendic, S, Berggren, P-O

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Sex- and Female Age-Dependent Differences in Gene Expression in Diffuse Large B-Cell Lymphoma-Possible Estrogen Effects by Huang, Dan, Berglund, Mattias, Damdimopoulos, Anastasios, Antonson, Per, Lindskog, Cecilia, Enblad, Gunilla, Amini, Rose-Marie, Okret, Sam

“…For most lymphomas, including diffuse large B-cell lymphoma (DLBCL), the male incidence is higher, and the prognosis is worse compared to females. The reasons…”
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Lipidomic analysis of human primary hepatocytes following LXR activation with GW3965 identifies AGXT2L1 as a main target associated to changes in phosphatidylethanolamine by Santinha, Deolinda, Klopot, Anna, Marques, Igor, Ellis, Ewa, Jorns, Carl, Johansson, Helene, Melo, Tânia, Antonson, Per, Jakobsson, Tomas, Félix, Vítor, Gustafsson, Jan-Åke, Domingues, Maria Rosário, Mode, Agneta, Helguero, Luisa A.

“…•GW3965 increases the ratio of monounsaturated / saturated fatty acid ratio.•GW3965 promotes phosphatidylethanolamine and phosphatidylcholine remodeling.•LXR…”
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Estrogen receptor β exon 3-deleted mouse: The importance of non-ERE pathways in ERβ signaling by Maneix, Laure, Antonson, Per, Humire, Patricia, Rochel-Maia, Sabrina, Castañeda, Jessica, Omoto, Yoko, Kim, Hyun-Jin, Warner, Margaret, Gustafsson, Jan-Åke

“…Significance Estrogen receptor β (ERβ) is thought to be the predominant nuclear receptor that regulates estrogen signaling in a wide variety of tissues. In…”
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