Search Results - "Antoniw, P"

Formatting antibody fragments to mediate specific therapeutic functions by Weir, A N C, Nesbitt, A, Chapman, A P, Popplewell, A G, Antoniw, P, Lawson, A D G

“…Monoclonal antibodies are increasingly being used as therapeutic agents in a wide range of indications, including oncology, inflammation and infectious…”
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Prolonged in Vivo Residence Times of Antibody Fragments Associated with Albumin by Smith, Bryan J, Popplewell, Andrew, Athwal, Dee, Chapman, Andrew P, Heywood, Sam, West, Shauna M, Carrington, Bruce, Nesbitt, Andrew, Lawson, Alastair D. G, Antoniw, Pari, Eddelston, Alison, Suitters, Amanda

“…Antibody fragments can be expressed at a high level in microbial systems, but they may have limited therapeutic value because they are rapidly eliminated from…”
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A cytotoxic agent can be generated selectively at cancer sites by BAGSHAWE, K. D, SPRINGER, C. J, SEARLE, F, ANTONIW, P, SHARMA, S. K, MELTON, R. G, SHERWOOD, R. F

“…Attempts to improve the selectivity of anti-cancer agents by conjugating them to antibodies directed at tumour associated antigens have demonstrated tumour…”
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Preparation and preclinical evaluation of humanised A33 immunoconjugates for radioimmunotherapy by KING, D. J, ANTONIW, P, BALDOCK, D, MACINTOSH, J, GOFTON, C, YARRANTON, G. T, MCWILLIAMS, W, SHOCHAT, D, LEICHNER, P. K, WELT, S, OLD, L. J, MOUNTAIN, A, OWENS, R. J, ADAIR, J. R, HAINES, A. M. R, FARNSWORTH, A. P. H, FINNEY, H, LAWSON, A. D. G, LYONS, A, BAKER, T. S

“…A humanised IgG1/k version of A33 (hA33) has been constructed and expressed with yields up to 700 mg l-1 in mouse myeloma NS0 cells in suspension culture. The…”
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Radioimmunotherapy of colorectal carcinoma xenografts in nude mice with yttrium-90 A33 IgG and Tri-Fab (TFM) by ANTONIW, P, FARNSWORTH, A. P. H, YARRANTON, G. T, KING, D. J, TURNER, A, HAINES, A. M. R, MOUTAIN, A, MACKINTOSH, J, SHOCHAT, D, HUMM, J, WELT, S, OLD, L. J

“…The monoclonal antibody A33 recognises a tumour-associated antigen on human colorectal carcinoma, and has undergone preliminary evaluation in the clinic where…”
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Therapeutic antibody fragments with prolonged in vivo half-lives by Chapman, Andrew P, Antoniw, Pari, Spitali, Mariangela, West, Shauna, Stephens, Sue, King, David J

“…Antibody fragments can be isolated rapidly using techniques such as phage display and can be expressed to high levels in microbial systems. However, to date…”
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Disposition of the prodrug 4-( (2-chloroethyl) amino) benzoyl-L-glutamic acid and its active parent drug in mice by ANTONIW, P, SPRINGER, C. J, BAGSHAWE, K. D, SEARLE, F, MELTON, R. G, ROGERS, G. T, BURKE, P. J, SHERWOOD, R. F

“…A novel therapy for improving selectivity in cancer chemotherapy aims to modify distribution of a cytotoxic drug by generating it selectively at tumour sites…”
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Antibody directed enzyme prodrug therapy (ADEPT): clinical report by Bagshawe, K D, Sharma, S K, Springer, C J, Antoniw, P, Boden, J A, Rogers, G T, Burke, P J, Melton, R G, Sherwood, R F

“…Following an extensive series of studies in nude mice with human xenografts a pilot scale clinical trial of antibody directed enzyme prodrug therapy has been…”
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Antibody directed enzyme prodrug therapy (ADEPT): a three phase system by Sharma, S K, Bagshawe, K D, Springer, C J, Burke, P J, Rogers, G T, Boden, J A, Antoniw, P, Melton, R G, Sherwood, R F

“…Monoclonal anti-CEA antibody, A5B7, and its fragments conjugated to CPG2 localize to a peak concentration in the LS174T xenografts within 24 h after injection,…”
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Selective uptake of toxic nucleoside (125IUdR) by resistant cancer by Bagshawe, K D, Sharma, K, Southall, P J, Boden, J A, Boxer, G M, Patridge, T A, Antoniw, P, Pedley, R B

“…We report uptake of a thymidine analogue 125-Iodine-5-iodo-2'-deoxyuridine (125IUdR) by nude mice bearing human xenografts of choriocarcinoma or colonic…”
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Plasma and tissue disposition of mitozolomide in mice by BRINDLEY, C. J, ANTONIW, P, NEWLANDS, E. S

“…When mitozolomide was administered i.p. to mice, drug disposition appeared to fit a simple, one-compartment kinetic model with an elimination half-life of less…”
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Improved tumor targeting with chemically cross-linked recombinant antibody fragments by KING, D. J, TURNER, A, MILLAR, K, MILLICAN, T. A, BOYCE, B. A, ANTONIW, P, MOUNTAIN, A, BEGENT, R. H. J, SHOCHAT, D, YARRANTON, G. T, FARNSWORTH, A. P. H, ADAIR, J. R, OWENS, R. J, PEDLEY, R. B, BALDOCK, D, PROUDFOOT, K. A, LAWSON, A. D. G, BEELEY, N. R. A

“…The construction and use of recombinant chimeric and later fully humanized (CDR-grafted) antibodies to tumor-associated antigens has reduced the immune…”
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Novel prodrugs which are activated to cytotoxic alkylating agents by carboxypeptidase G2 by Springer, Caroline J, Antoniw, Pari, Bagshawe, Searle, Frances, Bisset, Graham M. F, Jarman, Michael

“…The synthesis of three novel prodrugs, 4-[bis[2-(mesyloxy)ethyl]amino]benzoyl-L-glutamic acid (7),…”
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F(ab′) 2 molecules made from Escherichia coli produced Fab′ with hinge sequences conferring increased serum survival in an animal model by Humphreys, David P., Vetterlein, Olivia M., Chapman, Andrew P., King, David J., Antoniw, Pari, Suitters, Amanda J., Reeks, Dominic G., Parton, Ted A.H., King, Lloyd M., Smith, Bryan J., Lang, Volker, Stephens, Paul E.

“…Fab′s with hinges based on the human γ1 sequence containing 1, 2, or 4 cysteines have been produced by high level Escherichia coli periplasmic secretion, and…”
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F(ab') sub(2) molecules made from Escherichia coli produced Fab' with hinge sequences conferring increased serum survival in an animal model by Humphreys, D P, Vetterlein, OM, Chapman, A P, King, D J, Antoniw, P, Suitters, A J, Reeks, D G, Parton, TAH, King, L M, Smith, B J, Lang, V, Stephens, P E

“…Fab's with hinges based on the human gamma 1 sequence containing 1, 2, or 4 cysteines have been produced by high level Escherichia coli periplasmic secretion,…”
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An in vivo model for screening peptidomimetic inhibitors of gelatinase A by Chander, S K, Antoniw, P, Beeley, N R, Boyce, B, Crabbe, T, Docherty, A J, Leonard, J, Mason, B, Millar, K, Millican, A T

“…Gelatinase A, a matrix metalloproteinase, is frequently associated with human solid tumors, and its secretion and activation in the tumor milieu is considered…”
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Ablation of human choriocarcinoma xenografts in nude mice by antibody-directed enzyme prodrug therapy (ADEPT) with three novel compounds by Springer, C J, Bagshawe, K D, Sharma, S K, Searle, F, Boden, J A, Antoniw, P, Burke, P J, Rogers, G T, Sherwood, R F, Melton, R G

“…Three novel prodrugs have been designed for use as anticancer agents. Each is a bifunctional alkylating agent which has been protected to form a relatively…”
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Comparison of half-lives and cytotoxicity of N-chloroethyl-4-amino and N-mesyloxyethyl-benzoyl compounds, products of prodrugs in antibody-directed enzyme prodrug therapy (ADEPT) by Springer, C J, Antoniw, P, Bagshawe, K D, Wilman, D E

“…The synthesis of two novel drugs, 4-[bis[2-(mesyloxy)ethyl]amino]benzoic acid (7) and 4-[(2-chloroethyl)[2-(mesyloxy)ethyl]amino]benzoic acid (8) is described…”
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Pharmacokinetics and toxicity of the epijophyllotoxin derivative etoposide (VP 16-213) in patients with gestational choriocarcinoma and malignant teratoma by BRINDLEY, C. J, ANTONIW, P, NEWLANDS, E. S, BAGSHAWE, K. D

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Pharmacokinetics and toxicity of the epipodophyllotoxin derivative etoposide (VP 16-213) in patients with gestational choriocarcinoma and malignant teratoma by Brindley, C J, Antoniw, P, Newlands, E S, Bagshawe, K D

“…Serum levels of etoposide obtained 5 min after administration of 100 mg/m2 were between 11 and 30 micrograms/ml. By 24 h after drug administration, serum…”
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