Search Results - "Antoniou, Antony N."

Salmonella Exhibit Altered Cellular Localization in the Presence of HLA-B27 and Codistribute with Endo-Reticular Membrane by Kriston-Vizi, Janos, Lenart, Izabela, Iwawaki, Takao, Gould, Keith, Nesbeth, Darren, Powis, Simon J., Antoniou, Antony N.

“…Salmonella enteritica (S. enteritica) induce and require unfolded protein response (UPR) pathways for intracellular replication. Salmonella infections can lead…”
Get full text

F pocket flexibility influences the tapasin dependence of two differentially disease‐associated MHC Class I proteins by Abualrous, Esam T., Fritzsche, Susanne, Hein, Zeynep, Al‐Balushi, Mohammed S., Reinink, Peter, Boyle, Louise H., Wellbrock, Ursula, Antoniou, Antony N., Springer, Sebastian

“…The human MHC class I protein HLA‐B*27:05 is statistically associated with ankylosing spondylitis, unlike HLA‐B*27:09, which differs in a single amino acid in…”
Get full text

High-content screening image dataset and quantitative image analysis of Salmonella infected human cells by Antoniou, Antony N, Powis, Simon J, Kriston-Vizi, Janos

“…Salmonella bacteria can induce the unfolded protein response, a cellular stress response to misfolding proteins within the endoplasmic reticulum. Salmonella…”
Get full text

Intrinsic Folding Properties of the HLA-B27 Heavy Chain Revealed by Single Chain Trimer Versions of Peptide-Loaded Class I Major Histocompatibility Complex Molecules by Lenart, Izabela, Truong, Linh-Huyen, Nguyen, Dinh Dung, Rasiukienė, Olga, Tsao, Edward, Armstrong, Jonathan, Kumar, Pankaj, McHugh, Kirsty, Pereira, Branca I., Maan, Balraj S., Garstka, Malgorzata A., Bowness, Paul, Blake, Neil, Powis, Simon J., Gould, Keith, Nesbeth, Darren, Antoniou, Antony N.

“…Peptide-loaded Major Histocompatibility Complex (pMHC) class I molecules can be expressed in a single chain trimeric (SCT) format, composed of a specific…”
Get full text

Calreticulin-dependent recycling in the early secretory pathway mediates optimal peptide loading of MHC class I molecules by Howe, Christopher, Garstka, Malgorzata, Al-Balushi, Mohammed, Ghanem, Esther, Antoniou, Antony N, Fritzsche, Susanne, Jankevicius, Gytis, Kontouli, Nasia, Schneeweiss, Clemens, Williams, Anthony, Elliott, Tim, Springer, Sebastian

“…Calreticulin is a lectin chaperone of the endoplasmic reticulum (ER). In calreticulin‐deficient cells, major histocompatibility complex (MHC) class I molecules…”
Get full text

HLA-B27 homodimers and free H chains are stronger ligands for leukocyte Ig-like receptor B2 than classical HLA class I by Giles, Joanna, Shaw, Jackie, Piper, Christopher, Wong-Baeza, Isabel, McHugh, Kirsty, Ridley, Anna, Li, Demin, Lenart, Izabela, Antoniou, Antony N, DiGleria, Katilin, Kuroki, Kimiko, Maenaka, Katsumi, Bowness, Paul, Kollnberger, Simon

“…Possession of HLA-B27 (B27) strongly predisposes to the development of spondyloarthritis. B27 forms classical heterotrimeric complexes with β(2)-microglobulin…”
Get full text

The multi‐faceted nature of HLA class I dimer molecules by Campbell, Elaine C., Antoniou, Antony N., Powis, Simon J.

“…Summary The canonical role of major histocompatibility complex class I (MHCI) molecules in antigen presentation involves the recognition of a short peptide of…”
Get full text

Multistep Autoactivation of Asparaginyl Endopeptidase in Vitro and in Vivo by Li, Dongtao Ni, Matthews, Stephen P., Antoniou, Antony N., Mazzeo, Daniela, Watts, Colin

“…Mammalian asparaginyl endopeptidase (AEP) or legumain is a recently discovered lysosomal cysteine protease that specifically cleaves after asparagine residues…”
Get full text

The MHC Class I heavy chain structurally conserved cysteines 101 and 164 participate in HLA-B27 dimer formation by Lenart, Izabela, Guiliano, David B, Burn, Garth, Campbell, Elaine C, Morley, Kenneth D, Fussell, Helen, Powis, Simon J, Antoniou, Antony N

“…The human leukocyte antigen (HLA)-B27 is strongly associated with a group of inflammatory arthritic disorders known as the spondyloarthropathies (SpAs). The…”
Get more information

Assembly and export of MHC class I peptide ligands by Antoniou, Antony N, Powis, Simon J, Elliott, Tim

“…During the assembly of MHC class I molecules with peptide, a series of transient interactions are made with endoplasmic reticulum-resident chaperones and MHC…”
Get full text

Major Histocompatibility Complex Class I-ERp57-Tapasin Interactions within the Peptide-loading Complex by Santos, Susana G., Campbell, Elaine C., Lynch, Sarah, Wong, Vincent, Antoniou, Antony N., Powis, Simon J.

“…The endoplasmic reticulum-located multimolecular peptide-loading complex functions to load optimal peptides onto major histocompatibility complex (MHC) class I…”
Get full text

The oxidative folding and misfolding of human leukocyte antigen-b27 by Antoniou, Antony N, Guiliano, David B, Lenart, Izabela, Burn, Garth, Powis, Simon J

“…The major histocompatibility complex class I molecule human leukocyte antigen (HLA)-B27 is strongly associated with a group of inflammatory arthritic disorders…”
Get more information

Formation of HLA-B27 Homodimers and Their Relationship to Assembly Kinetics by Antoniou, Antony N., Ford, Stuart, Taurog, Joel D., Butcher, Geoffrey W., Powis, Simon J.

“…The human HLA-B27 class I molecule exhibits a strong association with the inflammatory arthritic disorder ankylosing spondylitis and other related…”
Get full text

Measuring Synthesis and Degradation of MHC Class I Molecules by Powis, Simon J, Antoniou, Antony N

“…Major histocompatibility complex (MHC) class I molecules function to present pathogen derived peptides to cytotoxic T cells and act as ligands for Natural…”
Get more information

Pathogenicity of Misfolded and Dimeric HLA-B27 Molecules by Antoniou, Antony N., Lenart, Izabela, Guiliano, David B.

“…The association between HLA-B27 and the group of autoimmune inflammatory arthritic diseases, the spondyloarthropathies (SpAs) which include ankylosing…”
Get full text

The major histocompatibility complex class I immunopeptidome of extracellular vesicles by Synowsky, Silvia A., Shirran, Sally L., Cooke, Fiona G.M., Antoniou, Antony N., Botting, Catherine H., Powis, Simon J.

“…Extracellular vesicles (EVs) are released by most cell types and have been associated with multiple immunomodulatory functions. MHC class I molecules have…”
Get full text

Tapasin dependence of major histocompatibility complex class I molecules correlates with their conformational flexibility by Garstka, Malgorzata Anna, Fritzsche, Susanne, Lenart, Izabela, Hein, Zeynep, Jankevicius, Gytis, Boyle, Louise H., Elliott, Tim, Trowsdale, John, Antoniou, Antony N., Zacharias, Martin, Springer, Sebastian

“…ABSTRACT Major histocompatibility complex (MHC) class I molecules present cell internally derived peptides at the plasma membrane for surveillance by cytotoxic…”
Get full text

Polymorphisms in the F Pocket of HLA–B27 Subtypes Strongly Affect Assembly, Chaperone Interactions, and Heavy‐Chain Misfolding by Guiliano, David B., North, Helen, Panayoitou, Eleni, Campbell, Elaine C., McHugh, Kirsty, Cooke, Fiona G. M., Silvestre, Marine, Bowness, Paul, Powis, Simon J., Antoniou, Antony N.

“…Objective HLA–B27 is associated with the inflammatory spondyloarthritides (SpA), although subtypes HLA–B*27:06 and HLA–B*27:09 are not. These subtypes differ…”
Get full text

Endoplasmic Reticulum Degradation–Enhancing α‐Mannosidase–like Protein 1 Targets Misfolded HLA–B27 Dimers for Endoplasmic Reticulum–Associated Degradation by Guiliano, David B., Fussell, Helen, Lenart, Izabela, Tsao, Edward, Nesbeth, Darren, Fletcher, Adam J., Campbell, Elaine C., Yousaf, Nasim, Williams, Sarah, Santos, Susana, Cameron, Amy, Towers, Greg J., Kellam, Paul, Hebert, Daniel N., Gould, Keith G., Powis, Simon J., Antoniou, Antony N.

“…Objective HLA–B27 forms misfolded heavy chain dimers, which may predispose individuals to inflammatory arthritis by inducing endoplasmic reticulum (ER) stress…”
Get full text

Interactions formed by individually expressed TAP1 and TAP2 polypeptide subunits by Antoniou, Antony N., Ford, Stuart, Pilley, Elizabeth S., Blake, Neil, Powis, Simon J.

“…Summary The transporter associated with antigen processing (TAP) supplies peptides into the lumen of the endoplasmic reticulum (ER) for binding by major…”
Get full text