Search Results - "Antoniou, Antonis C"

BOADICEA: a comprehensive breast cancer risk prediction model incorporating genetic and nongenetic risk factors by Lee, Andrew, Mavaddat, Nasim, Wilcox, Amber N., Cunningham, Alex P., Carver, Tim, Hartley, Simon, Babb de Villiers, Chantal, Izquierdo, Angel, Simard, Jacques, Schmidt, Marjanka K., Walter, Fiona M., Chatterjee, Nilanjan, Garcia-Closas, Montserrat, Tischkowitz, Marc, Pharoah, Paul, Easton, Douglas F., Antoniou, Antonis C.

“…Purpose Breast cancer (BC) risk prediction allows systematic identification of individuals at highest and lowest risk. We extend the Breast and Ovarian…”
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CanRisk Tool-A Web Interface for the Prediction of Breast and Ovarian Cancer Risk and the Likelihood of Carrying Genetic Pathogenic Variants by Carver, Tim, Hartley, Simon, Lee, Andrew, Cunningham, Alex P, Archer, Stephanie, Babb de Villiers, Chantal, Roberts, Jonathan, Ruston, Rod, Walter, Fiona M, Tischkowitz, Marc, Easton, Douglas F, Antoniou, Antonis C

“…The CanRisk Tool (https://canrisk.org) is the next-generation web interface for the latest version of the BOADICEA (Breast and Ovarian Analysis of Disease…”
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Cost-effectiveness of Population-Based BRCA1, BRCA2, RAD51C, RAD51D, BRIP1, PALB2 Mutation Testing in Unselected General Population Women by Manchanda, Ranjit, Patel, Shreeya, Gordeev, Vladimir S, Antoniou, Antonis C, Smith, Shantel, Lee, Andrew, Hopper, John L, MacInnis, Robert J, Turnbull, Clare, Ramus, Susan J, Gayther, Simon A, Pharoah, Paul D P, Menon, Usha, Jacobs, Ian, Legood, Rosa

“…The cost-effectiveness of population-based panel testing for high- and moderate-penetrance ovarian cancer (OC)/breast cancer (BC) gene mutations is unknown. We…”
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Prevalence and Penetrance of Major Genes and Polygenes for Colorectal Cancer by Win, Aung Ko, Jenkins, Mark A, Dowty, James G, Antoniou, Antonis C, Lee, Andrew, Giles, Graham G, Buchanan, Daniel D, Clendenning, Mark, Rosty, Christophe, Ahnen, Dennis J, Thibodeau, Stephen N, Casey, Graham, Gallinger, Steven, Le Marchand, Loïc, Haile, Robert W, Potter, John D, Zheng, Yingye, Lindor, Noralane M, Newcomb, Polly A, Hopper, John L, MacInnis, Robert J

“…Although high-risk mutations in identified major susceptibility genes (DNA mismatch repair genes and ) account for some familial aggregation of colorectal…”
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Polygenic scores in cancer by Yang, Xin, Kar, Siddhartha, Antoniou, Antonis C., Pharoah, Paul D. P.

“…Since the publication of the first genome-wide association study for cancer in 2007, thousands of common alleles that are associated with the risk of cancer…”
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Genetic susceptibility to breast cancer by Mavaddat, Nasim, Antoniou, Antonis C., Easton, Douglas F., Garcia-Closas, Montserrat

“…Genetic and lifestyle/environmental factors are implicated in the aetiology of breast cancer. This review summarizes the current state of knowledge on rare…”
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Risks of second non-breast primaries following breast cancer in women: a systematic review and meta-analysis by Allen, Isaac, Hassan, Hend, Sofianopoulou, Eleni, Eccles, Diana, Turnbull, Clare, Tischkowitz, Marc, Pharoah, Paul, Antoniou, Antonis C

“…Second primary cancer incidence is rising among breast cancer survivors. We examined the risks of non-breast second primaries, in combination and at specific…”
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Germline RAD51C mutations confer susceptibility to ovarian cancer by Loveday, Chey, Turnbull, Clare, Ruark, Elise, Xicola, Rosa Maria Munoz, Ramsay, Emma, Hughes, Deborah, Warren-Perry, Margaret, Snape, Katie, Eccles, Diana, Evans, D Gareth, Gore, Martin, Renwick, Anthony, Seal, Sheila, Antoniou, Antonis C, Rahman, Nazneen

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Comparative validation of the BOADICEA and Tyrer-Cuzick breast cancer risk models incorporating classical risk factors and polygenic risk in a population-based prospective cohort of women of European ancestry by Pal Choudhury, Parichoy, Brook, Mark N, Hurson, Amber N, Lee, Andrew, Mulder, Charlotta V, Coulson, Penny, Schoemaker, Minouk J, Jones, Michael E, Swerdlow, Anthony J, Chatterjee, Nilanjan, Antoniou, Antonis C, Garcia-Closas, Montserrat

“…The Breast and Ovarian Analysis of Disease Incidence and Carrier Estimation Algorithm (BOADICEA) and the Tyrer-Cuzick breast cancer risk prediction models are…”
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Evaluating clinician acceptability of the prototype CanRisk tool for predicting risk of breast and ovarian cancer: A multi-methods study by Archer, Stephanie, Babb de Villiers, Chantal, Scheibl, Fiona, Carver, Tim, Hartley, Simon, Lee, Andrew, Cunningham, Alex P, Easton, Douglas F, McIntosh, Jennifer G, Emery, Jon, Tischkowitz, Marc, Antoniou, Antonis C, Walter, Fiona M

“…There is a growing focus on the development of multi-factorial cancer risk prediction algorithms alongside tools that operationalise them for clinical use…”
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Potential of polygenic risk scores for improving population estimates of women’s breast cancer genetic risks by Wolfson, Michael, Gribble, Steve, Pashayan, Nora, Easton, Douglas F., Antoniou, Antonis C., Lee, Andrew, van Katwyk, Sasha, Simard, Jacques

“…Purpose Breast cancer risk has conventionally been assessed using family history (FH) and rare high/moderate penetrance pathogenic variants (PVs), notably in…”
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Implementation and external validation of the Cambridge Multimorbidity Score in the UK Biobank cohort by Harrison, Hannah, Ip, Samantha, Renzi, Cristina, Li, Yangfan, Barclay, Matthew, Usher-Smith, Juliet, Lyratzopoulos, Georgios, Wood, Angela, Antoniou, Antonis C

“…Patients with multiple conditions present a growing challenge for healthcare provision. Measures of multimorbidity may support clinical management, healthcare…”
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A New Comprehensive Colorectal Cancer Risk Prediction Model Incorporating Family History, Personal Characteristics, and Environmental Factors by Zheng, Yingye, Hua, Xinwei, Win, Aung K, MacInnis, Robert J, Gallinger, Steven, Marchand, Loic Le, Lindor, Noralane M, Baron, John A, Hopper, John L, Dowty, James G, Antoniou, Antonis C, Zheng, Jiayin, Jenkins, Mark A, Newcomb, Polly A

“…Reducing colorectal cancer incidence and mortality through early detection would improve efficacy if targeted. We developed a colorectal cancer risk prediction…”
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Letter to the editor: a response to Ming's study on machine learning techniques for personalized breast cancer risk prediction by Giardiello, Daniele, Antoniou, Antonis C, Mariani, Luigi, Easton, Douglas F, Steyerberg, Ewout W

“…Availability of data and materials Not applicable…”
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Chromatin interactome mapping at 139 independent breast cancer risk signals by Beesley, Jonathan, Sivakumaran, Haran, Moradi Marjaneh, Mahdi, Lima, Luize G, Hillman, Kristine M, Kaufmann, Susanne, Tuano, Natasha, Hussein, Nehal, Ham, Sunyoung, Mukhopadhyay, Pamela, Kazakoff, Stephen, Lee, Jason S, Michailidou, Kyriaki, Barnes, Daniel R, Antoniou, Antonis C, Fachal, Laura, Dunning, Alison M, Easton, Douglas F, Waddell, Nicola, Rosenbluh, Joseph, Möller, Andreas, Chenevix-Trench, Georgia, French, Juliet D, Edwards, Stacey L

“…Genome-wide association studies have identified 196 high confidence independent signals associated with breast cancer susceptibility. Variants within these…”
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BOADICEA model: updates to the BRCA2 breast cancer risks for ages 60 years and older by Ficorella, Lorenzo, Yang, Xin, Easton, Douglas F, Antoniou, Antonis C

“…Breast cancer risks in older pathogenic variant carriers are understudied. Recent studies show a marked decline in the relative risk at older ages. We used…”
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The future of early cancer detection by Fitzgerald, Rebecca C., Antoniou, Antonis C., Fruk, Ljiljana, Rosenfeld, Nitzan

“…A proactive approach to detecting cancer at an early stage can make treatments more effective, with fewer side effects and improved long-term survival…”
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Effect of Chest X-Rays on the Risk of Breast Cancer Among BRCA1/2 Mutation Carriers in the International BRCA1/2 Carrier Cohort Study: A Report from the EMBRACE, GENEPSO, GEO-HEBON, and IBCCS Collaborators’ Group by Andrieu, Nadine, Easton, Douglas F, Chang-Claude, Jenny, Rookus, Matti A, Brohet, Richard, Cardis, Elisabeth, Antoniou, Antonis C, Wagner, Teresa, Simard, Jacques, Evans, Gareth, Peock, Susan, Fricker, Jean-Pierre, Nogues, Catherine, Van't Veer, Laura, Van Leeuwen, Flora E, Goldgar, David E

“…Women who carry germline mutations in the BRCA1 and BRCA2 genes are at greatly increased risk of breast cancer (BC). Numerous studies have shown that moderate…”
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Polygenic inheritance of breast cancer: Implications for design of association studies by Antoniou, Antonis C., Easton, Douglas F.

“…Susceptibility to breast cancer is likely to be the result of susceptibility alleles in many different genes. In particular, one segregation analysis of breast…”
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Correction: BOADICEA: a comprehensive breast cancer risk prediction model incorporating genetic and nongenetic risk factors by Lee, Andrew, Mavaddat, Nasim, Wilcox, Amber N., Cunningham, Alex P., Carver, Tim, Hartley, Simon, de Villiers, Chantal Babb, Izquierdo, Angel, Simard, Jacques, Schmidt, Marjanka K., Walter, Fiona M., Chatterjee, Nilanjan, Garcia-Closas, Montserrat, Tischkowitz, Marc, Pharoah, Paul, Easton, Douglas F., Antoniou, Antonis C.

“…This has now been corrected in both the PDF and HTML versions of the Article. The authors regret this error…”
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