Search Results - "Antonenko, Yuri"

Efficiency of mitochondrial uncoupling by modified butyltriphenylphosphonium cations and fatty acids correlates with lipophilicity of cations: Protonophoric vs leakage mechanisms by Rokitskaya, Tatyana I, Khailova, Ljudmila S, Korshunova, Galina A, Antonenko, Yuri N

“…In order to determine the share of protonophoric activity in the uncoupling action of lipophilic cations a number of analogues of butyltriphenylphosphonium…”
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The mitochondria-targeted derivative of the classical uncoupler of oxidative phosphorylation carbonyl cyanide m-chlorophenylhydrazone is an effective mitochondrial recoupler by Iaubasarova, Iliuza R, Khailova, Ljudmila S, Firsov, Alexander M, Grivennikova, Vera G, Kirsanov, Roman S, Korshunova, Galina A, Kotova, Elena A, Antonenko, Yuri N

“…The synthesis of a mitochondria-targeted derivative of the classical mitochondrial uncoupler carbonyl cyanide-m-chlorophenylhydrazone (CCCP) by alkoxy…”
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Synchronization of opening and closing of two gramicidin A channels pulled together by a linker: possible relevance to channel clustering by Novoderezhkin, Vladimir I, Rokitskaya, Tatyana I, Kotova, Elena A, Antonenko, Yuri N

“…The linear 15-mer peptide gramicidin A (gA) produced by is known to form the simplest natural ion channel in lipid membranes representing a head-to-head…”
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Pyrrolomycins Are Potent Natural Protonophores by Valderrama, Katherine, Pradel, Elizabeth, Firsov, Alexander M, Drobecq, Hervé, Bauderlique-le Roy, Hélène, Villemagne, Baptiste, Antonenko, Yuri N, Hartkoorn, Ruben Christiaan

“…The escalating burden of antibiotic drug resistance necessitates research into novel classes of antibiotics and their mechanism of action. Pyrrolomycins are a…”
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Effect of Alkyl Chain Length on Translocation of Rhodamine B n-Alkyl Esters across Lipid Membranes by Rokitskaya, Tatyana I., Korshunova, Galina A., Antonenko, Yuri N.

“…Voltage-dependent translocation of a series of cationic rhodamine B derivatives differing in n-alkyl chain length (ethyl, butyl, octyl, dodecyl, octadecyl)…”
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Fullerenol C60(OH)24 increases ion permeability of lipid membranes in a pH-dependent manner by Rokitskaya, Tatyana I., Antonenko, Yuri N.

“…Fullerenols are water-soluble analogs of fullerene exhibiting both antioxidant and prooxidant activities in vitro and in vivo. Here we report, for the first…”
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Selectivity of cation transport across lipid membranes by the antibiotic salinomycin by Rokitskaya, Tatyana I, Firsov, Alexander M, Khailova, Ljudmila S, Kotova, Elena A, Antonenko, Yuri N

“…The ionophoric antibiotic salinomycin is in the phase of preclinical tests against several types of malignant tumors including breast cancer. Notwithstanding,…”
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Protons migrate along interfacial water without significant contributions from jumps between ionizable groups on the membrane surface by Springer, Andreas, Hagen, Volker, Cherepanov, Dmitry A, Antonenko, Yuri N, Pohl, Peter

“…Proton diffusion along membrane surfaces is thought to be essential for many cellular processes such as energy transduction. Commonly, it is treated as a…”
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Threshold protective effect of deuterated polyunsaturated fatty acids on peroxidation of lipid bilayers by Firsov, Alexander M., Fomich, Maksim A., Bekish, Andrei V., Sharko, Olga L., Kotova, Elena A., Saal, Harry J., Vidovic, Dragoslav, Shmanai, Vadim V., Pratt, Derek A., Antonenko, Yuri N., Shchepinov, Mikhail S.

“…Autoxidation of polyunsaturated fatty acids (PUFAs) damages lipid membranes and generates numerous toxic by‐products implicated in neurodegeneration, aging,…”
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Rhodamine 19 Alkyl Esters as Effective Antibacterial Agents by Nazarov, Pavel A, Maximov, Vladislav S, Firsov, Alexander M, Karakozova, Marina V, Panfilova, Veronika, Kotova, Elena A, Skulachev, Maxim V, Antonenko, Yuri N

“…Mitochondria-targeted antioxidants (MTAs) have been studied quite intensively in recent years as potential therapeutic agents and vectors for the delivery of…”
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Membrane Elastic Deformations Modulate Gramicidin A Transbilayer Dimerization and Lateral Clustering by Kondrashov, Oleg V., Galimzyanov, Timur R., Pavlov, Konstantin V., Kotova, Elena A., Antonenko, Yuri N., Akimov, Sergey A.

“…Gramicidin A (gA) is a short β-helical peptide known to form conducting channels in lipid membranes because of transbilayer dimerization. The gA conducting…”
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Electrogenic and nonelectrogenic ion fluxes across lipid and mitochondrial membranes mediated by monensin and monensin ethyl ester by Antonenko, Yuri N., Rokitskaya, Tatyana I., Huczyński, Adam

“…Monensin is a carrier of cations through lipid membranes capable of exchanging sodium (potassium) cations for protons by an electroneutral mechanism, whereas…”
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Electrostatically induced recruitment of membrane peptides into clusters requires ligand binding at both interfaces by Antonenko, Yuri N, Horner, Andreas, Pohl, Peter

“…Protein recruitment to specific membrane locations may be governed or facilitated by electrostatic attraction, which originates from a multivalent ligand. Here…”
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Molecular Mechanisms Responsible for Pharmacological Effects of Genipin on Mitochondrial Proteins by Kreiter, Jürgen, Rupprecht, Anne, Zimmermann, Lars, Moschinger, Michael, Rokitskaya, Tatyana I., Antonenko, Yuri N., Gille, Lars, Fedorova, Maria, Pohl, Elena E.

“…Genipin, a natural compound from Gardenia jasminoides, is a well-known compound in Chinese medicine that is used for the treatment of cancer, inflammation, and…”
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Anomalous potentials on bilayer lipid membranes in the presence of usnic acid: Markin-Sokolov versus Nernst-Donnan equilibrium by Rokitskaya, Tatyana I., Kotova, Elena A., Antonenko, Yuri N.

“…[Display omitted] •Ionophoric properties of usnic acid (UA) are probed in bilayer lipid membranes (BLM)•With UA, BLM potential at 1-pH unit gradient is twice…”
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Minocycline prevents peroxidative permeabilization of cardiolipin-containing bilayer lipid membranes mediated by cytochrome c by Firsov, Alexander M., Kotova, Elena A., Antonenko, Yuri N.

“…Peroxidase activity of cytochrome c stimulated by interaction of the protein with cardiolipin is considered to be involved in the induction of mitochondrial…”
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Calcein leakage as a robust assay for cytochrome c/H2O2–mediated liposome permeabilization by Firsov, Alexander M., Kotova, Elena A., Antonenko, Yuri N.

“…Membrane-permeabilizing activity of cytochrome c (cyt c) in the presence of hydrogen peroxide associated with its functioning as peroxidase is considered…”
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Mitochondria-targeted antioxidants as highly effective antibiotics by Nazarov, Pavel A., Osterman, Ilya A., Tokarchuk, Artem V., Karakozova, Marina V., Korshunova, Galina A., Lyamzaev, Konstantin G., Skulachev, Maxim V., Kotova, Elena A., Skulachev, Vladimir P., Antonenko, Yuri N.

“…Mitochondria-targeted antioxidants are known to alleviate mitochondrial oxidative damage that is associated with a variety of diseases. Here, we showed that…”
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Mitochondrial uncoupling caused by a wide variety of protonophores is differently sensitive to carboxyatractyloside in rat heart and liver mitochondria by Khailova, Ljudmila S., Kirsanov, Roman S., Rokitskaya, Tatyana I., Krasnov, Vladimir S., Korshunova, Galina A., Kotova, Elena A., Antonenko, Yuri N.

“…Mitochondrial uncoupling by small-molecule protonophores is generally accepted to proceed via transmembrane proton shuttling. The idea of facilitating this…”
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Bicarbonate suppresses mitochondrial membrane depolarization induced by conventional uncouplers by Khailova, Ljudmila S., Vygodina, Tatyana V., Lomakina, Galina Y., Kotova, Elena A., Antonenko, Yuri N.

“…Bicarbonate has been known to modulate activities of various mitochondrial enzymes such as ATPase and soluble adenylyl cyclase. Here, we found that the ability…”
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