Search Results - "Antonello, Alessandra"

Total Synthesis of Five Thapsigargins: Guaianolide Natural Products Exhibiting Sub-Nanomolar SERCA Inhibition by Andrews, Stephen P., Ball, Matthew, Wierschem, Frank, Cleator, Ed, Oliver, Steven, Högenauer, Klemens, Simic, Oliver, Antonello, Alessandra, Hünger, Udo, Smith, Martin D., Ley, Steven V.

“…Herein we describe the total synthesis of five guaianolide natural products: thapsigargin, thapsivillosin C, thapsivillosin F, trilobolide and nortrilobolide…”
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A Route to the Thapsigargins from (S)-Carvone Providing a Substrate-Controlled Total Synthesis of Trilobolide, Nortrilobolide, and Thapsivillosin F by Oliver, Steven F., Högenauer, Klemens, Simic, Oliver, Antonello, Alessandra, Smith, Martin D., Ley, Steven V.

“…An entirely substrate‐controlled total synthesis of three members of the thapsigargin family (e.g. trilobolide) is achieved starting from (S)‐carvone. The…”
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Synthesis of the thapsigargins by Ley, S.V, Antonello, A, Balskus, E.P, Booth, D.T, Christensen, S.B, Cleator, E, Gold, H, Hogenauer, K, Hunger, U, Myers, R.M

“…The thapsigargins are a family of complex guaianolides with potent and selective Ca2+-modulating properties. This article documents the evolution of a…”
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Total Synthesis of Two Novel Subpicomolar Sarco/Endoplasmatic Reticulum Ca2+-ATPase Inhibitors Designed by an Analysis of the Binding Site of Thapsigargin by Søhoel, Helmer, Liljefors, Tommy, Ley, Steven V, Oliver, Steven F, Antonello, Alessandra, Smith, Martin D, Olsen, Carl Erik, Isaacs, John T, Christensen, S. Brøgger

“…Analysis of molecular interaction fields based on the published crystal structure of thapsigargin bound to the sarco/endoplasmatic reticulum Ca2+-ATPase and…”
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Multitarget-Directed Drug Design Strategy:  A Novel Molecule Designed To Block Epidermal Growth Factor Receptor (EGFR) and To Exert Proapoptotic Effects by Antonello, Alessandra, Tarozzi, Andrea, Morroni, Fabiana, Cavalli, Andrea, Rosini, Michela, Hrelia, Patrizia, Bolognesi, Maria Laura, Melchiorre, Carlo

“…The multifactorial mechanistic nature of cancer calls for the development of multifunctional therapeutic tools, i.e., single compounds able to interact with…”
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Design, Synthesis, and Biological Evaluation of Prazosin-Related Derivatives as Multipotent Compounds by Antonello, Alessandra, Hrelia, Patrizia, Leonardi, Amedeo, Marucci, Gabriella, Rosini, Michela, Tarozzi, Andrea, Tumiatti, Vincenzo, Melchiorre, Carlo

“…To combine in the same molecule α1-adrenoreceptor blocking and antioxidant properties, compounds 2−5 were designed and synthesized. All compounds were…”
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Prazosin-Related Compounds. Effect of Transforming the Piperazinylquinazoline Moiety into an Aminomethyltetrahydroacridine System on the Affinity for α1-Adrenoreceptors by Rosini, Michela, Antonello, Alessandra, Cavalli, Andrea, Bolognesi, Maria L, Minarini, Anna, Marucci, Gabriella, Poggesi, Elena, Leonardi, Amedeo, Melchiorre, Carlo

“…In a search for structurally new α1-adrenoreceptor (α1-AR) antagonists, prazosin (1)-related compounds 2−11 were synthesized and their affinity profiles were…”
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Cover Picture: Total Synthesis of Five Thapsigargins: Guaianolide Natural Products Exhibiting Sub-Nanomolar SERCA Inhibition (Chem. Eur. J. 20/2007) by Andrews, Stephen P., Ball, Matthew, Wierschem, Frank, Cleator, Ed, Oliver, Steven, Högenauer, Klemens, Simic, Oliver, Antonello, Alessandra, Hünger, Udo, Smith, Martin D., Ley, Steven V.

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Total Synthesis of Two Novel Subpicomolar Sarco/Endoplasmatic Reticulum Ca 2+ -ATPase Inhibitors Designed by an Analysis of the Binding Site of Thapsigargin by Søhoel, Helmer, Liljefors, Tommy, Ley, Steven V., Oliver, Steven F., Antonello, Alessandra, Smith, Martin D, Olsen, Carl Erik, Isaacs, John T., Christensen, S. Brøgger

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Polymethylene tetraamine backbone as template for the development of biologically active polyamines by Melchiorre, Carlo, Antonello, Alessandra, Banzi, Rita, Bolognesi, Maria Laura, Minarini, Anna, Rosini, Michela, Tumiatti, Vincenzo

“…The concept that polyamines may represent a universal template in the receptor recognition process is embodied in the design of ligands for different…”
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Prazosin-related compounds. Effect of transforming the piperazinylquinazoline moiety into an aminomethyltetrahydroacridine system on the affinity for alpha1-adrenoreceptors by Rosini, Michela, Antonello, Alessandra, Cavalli, Andrea, Bolognesi, Maria L, Minarini, Anna, Marucci, Gabriella, Poggesi, Elena, Leonardi, Amedeo, Melchiorre, Carlo

“…In a search for structurally new alpha(1)-adrenoreceptor (alpha(1)-AR) antagonists, prazosin (1)-related compounds 2-11 were synthesized and their affinity…”
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Prazosin-Related Compounds. Effect of Transforming the Piperazinylquinazoline Moiety into an Aminomethyltetrahydroacridine System on the Affinity for α 1 -Adrenoreceptors by Rosini, Michela, Antonello, Alessandra, Cavalli, Andrea, Bolognesi, Maria L., Minarini, Anna, Marucci, Gabriella, Poggesi, Elena, Leonardi, Amedeo, Melchiorre, Carlo

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Structure−Activity Relationships of Methoctramine-Related Polyamines as Muscular Nicotinic Receptor Noncompetitive Antagonists. 3. Effect of Inserting the Tetraamine Backbone into a Macrocyclic Structure by Bolognesi, Maria L, Bixel, M. Gabriele, Marucci, Gabriella, Bartolini, Manuela, Krauss, Michael, Angeli, Piero, Antonello, Alessandra, Rosini, Michela, Tumiatti, Vincenzo, Hucho, Ferdinand, Melchiorre, Carlo

“…The present article expands on the study of another aspect of structure−activity relationships of the polymethylene tetraamines, namely, the effect of…”
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Structure-activity relationships of methoctramine-related polyamines as muscular nicotinic receptor noncompetitive antagonists. 3.1 Effect of inserting the tetraamine backbone into a macrocyclic structure by BOLOGNESI, Maria L, BIXEL, M. Gabriele, MELCHIORRE, Carlo, MARUCCI, Gabriella, BARTOLINI, Manuela, KRAUSS, Michael, ANGELI, Piero, ANTONELLO, Alessandra, ROSINI, Michela, TUMIATTI, Vincenzo, HUCHO, Ferdinand

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Design, synthesis and biological evaluation of ambenonium derivatives as AChE inhibitors by Bolognesi, Maria Laura, Cavalli, Andrea, Andrisano, Vincenza, Bartolini, Manuela, Banzi, Rita, Antonello, Alessandra, Rosini, Michela, Melchiorre, Carlo

“…Ambenonium ( 1), an old AChE inhibitor, is endowed with an outstanding affinity and a peculiar mechanism of action that, taken together, make it a very…”
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A Route to the Thapsigargins from (S)-Carvone Providing a Substrate-Controlled Total Synthesis of Trilobolide, Nortrilobolide, and Thapsivillosin F by Oliver, Steven F., Högenauer, Klemens, Simic, Oliver, Antonello, Alessandra, Smith, Martin D., Ley, Steven V.

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A Route to the Thapsigargins from (S)‐Carvone Providing a Substrate‐Controlled Total Synthesis of Trilobolide, Nortrilobolide, and Thapsivillosin F by Oliver, Steven F., Högenauer, Klemens, Simic, Oliver, Antonello, Alessandra, Smith, Martin D., Ley, Steven V.

“…Eine vollständig substratkontrollierte Totalsynthese dreier Mitglieder der Thapsigargin‐Familie (darunter Trilobolid) gelang ausgehend von (S)‐Carvon. Die…”
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Bone Metastasis from Glioblastoma Multiforme Without Central Nervous System Relapse: A Case Report by FABI, Alessandra, VIDIRI, Antonello, CARAPELLA, Carmine, PACE, Andrea, OCCHIPINTI, Emanuele, CAROLI, Fabrizio, MIRRI, Alessandra, CARLINI, Paolo, COGNETI, Francesco

“…The extraneural diffusion of malignant gliomas is not frequent and some authors have reported single or multiple bone metastases from glioblastoma contemporary…”
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