Search Results - "Antonelli, Patrick"

Cochlear Implant Infections by Antonelli, Patrick J.

“…Cochlear implants (CIs) are associated with a range of infections. These infections present unique considerations because of their position relative to the…”
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Safety and efficacy of ebselen for the prevention of noise-induced hearing loss: a randomised, double-blind, placebo-controlled, phase 2 trial by Kil, Jonathan, Lobarinas, Edward, Spankovich, Christopher, Griffiths, Scott K, Antonelli, Patrick J, Lynch, Eric D, Le Prell, Colleen G

“…Noise-induced hearing loss is a leading cause of occupational and recreational injury and disease, and a major determinant of age-related hearing loss. No…”
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Cytotoxicity of Tetracyclines in Human Tympanic Membrane Fibroblasts by Dirain, Carolyn O., Antonelli, Patrick J.

“…Tetracyclines are less cytotoxic to tympanic membrane (TM) fibroblasts than quinolones. Use of quinolone ear drops after tympanostomy tube placement and for…”
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Risk for Tympanic Membrane Perforation After Quinolone Ear Drops for Acute Otitis Externa by Wang, Xi, Winterstein, Almut G, Alrwisan, Adel, Antonelli, Patrick J

“…Abstract Background This study examined whether the use of quinolone ear drops increased the risk of perforation with intact tympanic membranes and acute…”
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Antibiotic treatment to prevent pediatric acute otitis media infectious complications: A meta-analysis by Smolinski, Nicole E, Djabali, Emma J, Al-Bahou, Julie, Pomputius, Ariel, Antonelli, Patrick J, Winterstein, Almut G

“…Most US children with acute otitis media [AOM] receive prompt antibiotic treatment, though guidelines encourage watchful waiting. Previous systematic reviews…”
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Prevention and Management of Complications in Otosclerosis Surgery by Antonelli, Patrick J.

“…Surgical management of otosclerosis is a relatively safe and effective procedure, with a high rate of hearing improvement and a low rate of undesirable…”
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Potential Toxicity of Boric Acid Powder Otic Insufflation by Smith, Samuel H., Antonelli, Patrick J.

“…Objective Boric acid (BA) powder is commonly used to treat otologic conditions, such as mastoid bowl inflammation and chronic otitis externa. Exposure to 50 mg…”
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Watchful Waiting for Acute Otitis Media by Smolinski, Nicole E, Antonelli, Patrick J, Winterstein, Almut G

“…Updated guidelines continue to support watchful waiting as an option for uncomplicated acute otitis media (AOM) and provide explicit diagnostic criteria. To…”
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Quinolone Ear Drops and Achilles Tendon Rupture by Tran, Phuong T, Antonelli, Patrick J, Winterstein, Almut G

“…Abstract Background Delayed eardrum healing has been observed in the ear opposite to the ear treated with otic quinolones (OQ) in rats. Case reports describe…”
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Association of US Food and Drug Administration Removal of Indications for Use of Oral Quinolones With Prescribing Trends by Tran, Phuong T, Antonelli, Patrick J, Hincapie-Castillo, Juan M, Winterstein, Almut G

“…In May 2016, due to concerns of the risks outweighing the benefits, the US Food and Drug Administration (FDA) removed systemic quinolones' indications for…”
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Quinolone Ear Drops After Tympanostomy Tubes and the Risk of Eardrum Perforation: A Retrospective Cohort Study by Alrwisan, Adel, Antonelli, Patrick J., Winterstein, Almut G.

“…Background. This study investigated whether quinolone ear drops, with or without corticosteroids, increase the risk of perforation requiring tympanoplasty…”
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Tympanoplasty Healing Outcomes With Use of Postoperative Otic Quinolones by Kolb, Casey L., Dirain, Carolyn O., Antonelli, Patrick J.

“…Tympanoplasty usually results in tympanic membrane perforation (TMP) closure, but healing may be suboptimal (e.g., excess scarring). Factors that have been…”
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Effects of Common Ear Drops on Tympanic Membrane Healing in Rats by Dirain, Carolyn O., Kosko, Brendan, Antonelli, Patrick J.

“…Objective Ciprofloxacin + dexamethasone ear drops have been associated with higher rates of tympanic membrane perforations than ofloxacin. This was thought to…”
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Is Preoperative Computed Tomography Necessary or Useful for Primary Stapes Surgery? by Varadarajan, Varun V., Antonelli, Patrick J.

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Triangulation of pharmacoepidemiology and laboratory science to tackle otic quinolone safety by Winterstein, Almut G., Antonelli, Patrick J.

“…Background The scientific method requires studies with high internal and external validity. Though both are necessary, they do not go hand‐in‐hand: The more…”
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Efficacy of the mini‐meatoplasty by Varadarajan, Varun V., Antonelli, Patrick J.

“…Objectives The lateral meatoplasty is a well‐described technique for widening the lateral external auditory meatus. After bony canalplasty, the external…”
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Microbiome Analysis of Cholesteatoma by Gene Sequencing by Weiss, Joshua P, Antonelli, Patrick J, Dirain, Carolyn O

“…OBJECTIVE:To compare the microbial flora of cholesteatoma and normal middle ears using gene-based sequencing analysis. STUDY DESIGN:Controlled ex vivo human…”
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Effects of quinolone and poloxamer otic suspension on rat tympanic membranes by Dirain, Carolyn O., Antonelli, Patrick J.

“…Commercial quinolone ear drops (0.3%) delivered twice daily for 10 days cause tympanic membrane perforations (TMPs) in rats. We aimed to evaluate if a single…”
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The Effects of Steroids on Survival of Mouse and Human Tympanic Membrane Fibroblasts by Karnani, David N., Dirain, Carolyn O., Antonelli, Patrick J.

“…Objective Tympanic membrane (TM) fibroblast cytotoxicity of quinolone ear drops is enhanced by dexamethasone and fluocinolone. Hydrocortisone has not been…”
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Microbiome and Otic Quinolone Levels Following Tympanoplasty Assessed by Gelatin Sponge Analysis by Vijay, Arunima, Dirain, Carolyn O., Chen, Si, Haberman, Rex, Sharma, Abhisheak, Chiang, Yi‐Hua, Antonelli, Patrick J.

“…Objective To determine if absorbable gelatin sponge (AGS) can be used to assess the posttympanoplasty microbiome and otic antibiotic exposure. Study Design…”
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