Search Results - "Antollini, Silvia S."
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Alzheimer's Disease as a Membrane Disorder: Spatial Cross-Talk Among Beta-Amyloid Peptides, Nicotinic Acetylcholine Receptors and Lipid Rafts
Published in Frontiers in cellular neuroscience (18-07-2019)“…Biological membranes show lateral and transverse asymmetric lipid distribution. Cholesterol (Chol) localizes in both hemilayers, but in the external one it is…”
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Carlos Gutiérrez-Merino: Synergy of Theory and Experimentation in Biological Membrane Research
Published in Molecules (Basel, Switzerland) (01-02-2024)“…Professor Carlos Gutiérrez-Merino, a prominent scientist working in the complex realm of biological membranes, has made significant theoretical and…”
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Fatty Acid Regulation of Voltage- and Ligand-Gated Ion Channel Function
Published in Frontiers in physiology (28-11-2016)“…Free fatty acids (FFA) are essential components of the cell, where they play a key role in lipid and carbohydrate metabolism, and most particularly in cell…”
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Transbilayer asymmetry and sphingomyelin composition modulate the preferential membrane partitioning of the nicotinic acetylcholine receptor in Lo domains
Published in Archives of biochemistry and biophysics (01-02-2016)“…We have previously shown that the intact nicotinic acetylcholine receptor (AChR) lacks preference for Lo domains when reconstituted in a sphingomyelin (SM),…”
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Free cholesterol and cholesterol esters in bovine oocytes: Implications in survival and membrane raft organization after cryopreservation
Published in PloS one (07-07-2017)“…Part of the damage caused by cryopreservation of mammalian oocytes occurs at the plasma membrane. The addition of cholesterol to cell membranes as a strategy…”
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Very Long-chain Polyunsaturated Fatty Acids Are the Major Acyl Groups of Sphingomyelins and Ceramides in the Head of Mammalian Spermatozoa
Published in The Journal of biological chemistry (22-06-2007)“…Very long-chain (C24 to C34) polyunsaturated fatty acids (VLCPUFA) are important constituents of sphingomyelin (SM) and ceramide (Cer) in testicular germ…”
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Unique thermal behavior of sphingomyelin species with nonhydroxy and 2-hydroxy very-long-chain (C28-C32) PUFAs
Published in Journal of lipid research (01-08-2013)“…In rat germ cells and spermatozoa, sphingomyelin (SM) contains molecular species with nonhydroxy (n) and 2-hydroxy (h) very-long-chain polyunsaturated fatty…”
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Partition profile of the nicotinic acetylcholine receptor in lipid domains upon reconstitution[S]
Published in Journal of lipid research (01-09-2010)“…The nicotinic acetylcholine receptor (AChR) is in intimate contact with the lipids in its native membrane. Here we analyze the possibility that it is the…”
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Modulation of Nicotinic Acetylcholine Receptor Conformational State by Free Fatty Acids and Steroids
Published in The Journal of biological chemistry (01-08-2008)“…Steroids and free fatty acids (FFA) are noncompetitive antagonists of the nicotinic acetylcholine receptor (AChR). Their site of action is purportedly located…”
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10
New Synthetic Caffeine Analogs as Modulators of the Cholinergic System
Published in Molecular pharmacology (01-03-2022)“…Alzheimer's disease is a multifactorial neurodegenerative disorder. Since cholinergic deficit is a major factor in this disease, two molecular targets for its…”
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Cholesterol and desmosterol incorporation into ram sperm membrane before cryopreservation: Effects on membrane biophysical properties and sperm quality
Published in Biochimica et biophysica acta. Biomembranes (01-09-2020)“…Ram sperm are particularly sensitive to freeze-thawing mainly due to their lipid composition, limiting their use in artificial insemination programs. We…”
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Oleic Acid Could Act as a Channel Blocker in the Inhibition of nAChR: Insights from Molecular Dynamics Simulations
Published in The journal of physical chemistry. B (14-03-2024)“…The activation of the muscular nicotinic acetylcholine receptor (nAChR) produces the opening of the channel, with the consequent increase in the permeability…”
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13
Unique Effects of Different Fatty Acid Species on the Physical Properties of the Torpedo Acetylcholine Receptor Membrane
Published in The Journal of biological chemistry (11-01-2002)“…To study the effects produced by free fatty acids (FFA) on the biophysical properties of Torpedo marmorata nicotinic acetylcholine receptor-rich native…”
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Membrane Restructuring Events during the Enzymatic Generation of Ceramides with Very Long-Chain Polyunsaturated Fatty Acids
Published in Langmuir (10-04-2018)“…In rat sperm heads, sphingomyelin (SM) species that contain very long-chain polyunsaturated fatty acid (V-SM) become ceramides (V-Cer) after inducing in vitro…”
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Lipid Biochemical and Biophysical Changes in Rat Spermatozoa During Isolation and Functional Activation In Vitro1
Published in Biology of reproduction (01-12-2015)“…In spermatozoa isolated from rat epididymis, lipids are differentially modified after in vitro induction of capacitation (Cap) and the acrosomal reaction (AR)…”
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alpha 7-type acetylcholine receptor localization and its modulation by nicotine and cholesterol in vascular endothelial cells
Published in Journal of cellular biochemistry (01-11-2011)“…The neuronal-type α7 nicotinic acetylcholine receptor (α7AChR) is also found in various non-neural tissues, including vascular endothelium, where its peculiar…”
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Lipid Biochemical and Biophysical Changes in Rat Spermatozoa During Isolation and Functional Activation In Vitro
Published in Biology of reproduction (01-12-2015)“…In spermatozoa isolated from rat epididymis, lipids are differentially modified after in vitro induction of capacitation (Cap) and the acrosomal reaction (AR)…”
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18
Atypical surface behavior of ceramides with nonhydroxy and 2-hydroxy very long-chain (C28–C32) PUFAs
Published in Biochimica et biophysica acta (01-03-2014)“…Unique species of ceramide (Cer) with very-long-chain polyunsaturated fatty acid (VLCPUFA), mainly 28–32 carbon atoms, 4–5 double bonds, in nonhydroxy and…”
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The position of the double bond in monounsaturated free fatty acids is essential for the inhibition of the nicotinic acetylcholine receptor
Published in Biochimica et biophysica acta (01-11-2012)“…Free fatty acids (FFAs) are non-competitive antagonists of the nicotinic acetylcholine receptor (AChR). Their site of action is supposedly located at the…”
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20
Thermal behavior of liposomes containing PCs with long and very long chain PUFAs isolated from retinal rod outer segment membranes
Published in Journal of lipid research (01-09-2002)“…About one-fourth the phosphatidylcholines (PC) from retina photoreceptor rod outer segment (ROS) membranes contain docosahexaenoic acid (22:6n-3) at sn-2 and a…”
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