Search Results - "Antico, Odetta"

Deubiquitinating enzyme amino acid profiling reveals a class of ubiquitin esterases by De Cesare, Virginia, Lopez, Daniel Carbajo, Mabbitt, Peter D., Fletcher, Adam J., Soetens, Mathieu, Antico, Odetta, Wood, Nicola T., Virdee, Satpal

“…The reversibility of ubiquitination by the action of deubiquitinating enzymes (DUBs) serves as an important regulatory layer within the ubiquitin system…”
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Additional feedforward mechanism of Parkin activation via binding of phospho-UBL and RING0 in trans by Lenka, Dipti Ranjan, Dahe, Shakti Virendra, Antico, Odetta, Sahoo, Pritiranjan, Prescott, Alan R, Muqit, Miratul M K, Kumar, Atul

“…Loss-of-function Parkin mutations lead to early-onset of Parkinson's disease. Parkin is an auto-inhibited ubiquitin E3 ligase activated by dual phosphorylation…”
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Functional Diversification of SRSF Protein Kinase to Control Ubiquitin-Dependent Neurodevelopmental Signaling by Bustos, Francisco, Segarra-Fas, Anna, Nardocci, Gino, Cassidy, Andrew, Antico, Odetta, Davidson, Lindsay, Brandenburg, Lennart, Macartney, Thomas J., Toth, Rachel, Hastie, C. James, Moran, Jennifer, Gourlay, Robert, Varghese, Joby, Soares, Renata F., Montecino, Martin, Findlay, Greg M.

“…Conserved protein kinases with core cellular functions have been frequently redeployed during metazoan evolution to regulate specialized developmental…”
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Phosphorylation of Parkin at serine 65 is essential for its activation in vivo by McWilliams, Thomas G, Barini, Erica, Pohjolan-Pirhonen, Risto, Brooks, Simon P, Singh, François, Burel, Sophie, Balk, Kristin, Kumar, Atul, Montava-Garriga, Lambert, Prescott, Alan R, Hassoun, Sidi Mohamed, Mouton-Liger, François, Ball, Graeme, Hills, Rachel, Knebel, Axel, Ulusoy, Ayse, Di Monte, Donato A, Tamjar, Jevgenia, Antico, Odetta, Fears, Kyle, Smith, Laura, Brambilla, Riccardo, Palin, Eino, Valori, Miko, Eerola-Rautio, Johanna, Tienari, Pentti, Corti, Olga, Dunnett, Stephen B, Ganley, Ian G, Suomalainen, Anu, Muqit, Miratul M K

“…Mutations in PINK1 and Parkin result in autosomal recessive Parkinson's disease (PD). Cell culture and studies have elaborated the PINK1-dependent regulation…”
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Whole proteome copy number dataset in primary mouse cortical neurons by Antico, Odetta, Nirujogi, Raja S., Muqit, Miratul M.K.

“…The functional diversity of neurons is specified through their proteome resulting in elaborate and tightly regulated protein interaction networks and…”
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Metformin promotes tau aggregation and exacerbates abnormal behavior in a mouse model of tauopathy by Barini, Erica, Antico, Odetta, Zhao, Yingjun, Asta, Francesco, Tucci, Valter, Catelani, Tiziano, Marotta, Roberto, Xu, Huaxi, Gasparini, Laura

“…Alzheimer disease (AD) and other tauopathies develop cerebral intracellular inclusions of hyperphosphorylated tau. Epidemiological and experimental evidence…”
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PINK1-Parkin-Dependent Signaling in Neurons by Antico, Odetta

“…Over the last 30 years, mitochondrial dysfunction has emerged as a common feature of age-related neurodegenerative disease like Parkinson's disease (PD),…”
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Additional feedforward mechanism of Parkin activation via binding of phospho-UBL and RING0 in trans by Lenka, Dipti Ranjan, Dahe, Shakti Virendra, Antico, Odetta, Sahoo, Pritiranjan, Prescott, Alan R, Muqit, Miratul MK, Kumar, Atul

“…Loss-of-function Parkin mutations lead to early-onset of Parkinson’s disease. Parkin is an auto-inhibited ubiquitin E3 ligase activated by dual phosphorylation…”
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Development and characterization of phospho-ubiquitin antibodies to monitor PINK1-PRKN signaling in cells and tissue by Watzlawik, Jens O., Hou, Xu, Richardson, Tyrique, Lewicki, Szymon L., Siuda, Joanna, Wszolek, Zbigniew K., Cook, Casey N., Petrucelli, Leonard, DeTure, Michael, Dickson, Dennis W., Antico, Odetta, Muqit, Miratul M. K., Fishman, Jordan B., Pirani, Karima, Kumaran, Ravindran, Polinski, Nicole K., Fiesel, Fabienne C., Springer, Wolfdieter

“…The selective removal of dysfunctional mitochondria, a process termed mitophagy, is critical for cellular health and impairments have been linked to aging,…”
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Global ubiquitylation analysis of mitochondria in primary neurons identifies endogenous Parkin targets following activation of PINK1 by Antico, Odetta, Ordureau, Alban, Stevens, Michael, Singh, Francois, Nirujogi, Raja S, Gierlinski, Marek, Barini, Erica, Rickwood, Mollie L, Prescott, Alan, Toth, Rachel, Ganley, Ian G, Harper, J Wade, Muqit, Miratul M K

“…How activation of PINK1 and Parkin leads to elimination of damaged mitochondria by mitophagy is largely based on cell lines with few studies in neurons. Here,…”
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Structure-based design and characterization of Parkin-activating mutations by Stevens, Michael U, Croteau, Nathalie, Eldeeb, Mohamed A, Antico, Odetta, Zeng, Zhi Wei, Toth, Rachel, Durcan, Thomas M, Springer, Wolfdieter, Fon, Edward A, Muqit, Miratul Mk, Trempe, Jean-François

“…Autosomal recessive mutations in the Parkin gene cause Parkinson's disease. Parkin encodes an ubiquitin E3 ligase that functions together with the kinase PINK1…”
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Design and high-throughput implementation of MALDI-TOF/MS-based assays for Parkin E3 ligase activity by Traynor, Ryan, Moran, Jennifer, Stevens, Michael, Antico, Odetta, Knebel, Axel, Behrouz, Bahareh, Merchant, Kalpana, Hastie, C. James, Davies, Paul, Muqit, Miratul M.K., De Cesare, Virginia

“…Parkinson’s disease (PD) is a progressive neurological disorder that manifests clinically as alterations in movement as well as multiple non-motor symptoms…”
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Discovery and characterization of noncanonical E2-conjugating enzymes by Abdul Rehman, Syed Arif, Cazzaniga, Chiara, Di Nisio, Elena, Antico, Odetta, Knebel, Axel, Johnson, Clare, Şahin, Alp T, Ibrahim, Peter E G F, Lamoliatte, Frederic, Negri, Rodolfo, Muqit, Miratul M K, De Cesare, Virginia

“…E2-conjugating enzymes (E2s) play a central role in the enzymatic cascade that leads to the attachment of ubiquitin to a substrate. This process, termed…”
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IGH Repertoire Analysis In Multiple Myeloma (MM): Lack of Intra-Disease Homology and Occasional Clustering with Sequences of Other B-Cell Neoplasms Sharing Identical Geographical Origin by Ferrero, Simone, Capello, Daniela, Svaldi, Mirija, Drandi, Daniela, Boi, Michela, Barbiero, Sara, Gatti, Daniela, Rossi, Davide, Genuardi, Elisa, Antico, Odetta, Ghione, Paola, Zanni, Manuela, Rocci, Alberto, Bertoni, Francesco, Zucca, Emanuele, Gattei, Valter, Palumbo, Antonio, Cortelazzo, Sergio, Boccadoro, Mario, Gaidano, Gianluca, Ladetto, Marco

“…Abstract 2951 The identification of stereotyped immunoglobulin (IG) receptors has improved our knowledge on the pathogenesis of several B-cell malignancies,…”
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