Search Results - "Anti-cancer drugs"

Autophagy and doxorubicin resistance in cancer by Chen, Chao, Lu, Lu, Yan, Shichao, Yi, Huimei, Yao, Hui, Wu, Di, He, Guangchun, Tao, Xiaojun, Deng, Xiyun

“…Doxorubicin (DOX), also known as adriamycin, is a DNA topoisomerase II inhibitor and belongs to the family of anthracycline anticancer drugs. DOX is used for…”
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Selective poly adenylation predicts the efficacy of immunotherapy in patients with lung adenocarcinoma by multiple omics research by Wu, Liusheng, Zhong, Yanfeng, Yu, Xiaoya, Wu, Dingwang, Xu, Pengcheng, Lv, Le, Ruan, Xin, Liu, Qi, Feng, Yu, Liu, Jixian, Li, Xiaoqiang

“…The aim of this study was to find the application value of selective polyadenylation in immune cell infiltration, biological transcription function and risk…”
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Long-chain noncoding ribonucleic acids affect the survival and prognosis of patients with esophageal adenocarcinoma through the autophagy pathway: construction of a prognostic model by Wu, Liusheng, Zheng, Yuzhen, Ruan, Xin, Wu, Dingwang, Xu, Pengcheng, Liu, Jixian, Wu, Da, Li, Xiaoqiang

“…Autophagy-related long-chain noncoding ribonucleic acids play a vital role in the development of esophageal adenocarcinoma. This study aimed to construct a…”
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Chlorogenic acid induces reactive oxygen species generation and inhibits the viability of human colon cancer cells by Hou, Ni, Liu, Na, Han, Jia, Yan, Yuan, Li, Jie

“…Chlorogenic acid (CGA) is one of the polyphenols identified in the human diet. Previous studies have shown that CGA plays a protective role against liver…”
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Ibuprofen induces ferroptosis of glioblastoma cells via downregulation of nuclear factor erythroid 2-related factor 2 signaling pathway by Gao, Xingchun, Guo, Na, Xu, Hao, Pan, Tao, lei, Hong, Yan, Aili, Mi, Yajing, Xu, Lixian

“…Ferroptosis is a newly discovered type of cell death decided by iron-dependent lipid peroxidation, but its role in glioblastoma cell death remains unclear…”
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Spontaneous regression of tumour and the role of microbial infection – possibilities for cancer treatment by Kucerova, Petra, Cervinkova, Monika

“…This review deals with the role of microorganisms in spontaneous regression of a tumour. Spontaneous cancer regression is a phenomenon that has been described…”
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miR-21 modulates cisplatin resistance of gastric cancer cells by inhibiting autophagy via the PI3K/Akt/mTOR pathway by Gu, Yifan, Fei, Zhewei, Zhu, Ronghua

“…Resistance to cisplatin (DDP) remains a major obstacle in the control of gastric cancer (GC) progression. A previous study revealed that microRNA-21 (miR-21)…”
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Potential anticancer role of colchicine-based derivatives: an overview by Kumar, Ashok, Sharma, Parduman R, Mondhe, Dilip M

“…Colchicine, the main alkaloid of the poisonous plant meadow saffron (Colchicum autumnale L.), is a classical drug used for the treatment of gout and familial…”
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LncRNA MALAT1 promotes migration and invasion of non-small-cell lung cancer by targeting miR-206 and activating Akt/mTOR signaling by Tang, Yi, Xiao, GaoMing, Chen, YueJun, Deng, Yu

“…Long noncoding RNA (lncRNA) metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) functions as a crucial regulator of metastasis in lung cancer. The…”
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Rapid disease progression in patient with mismatch-repair deficiency pituitary ACTH-secreting adenoma treated with checkpoint inhibitor pembrolizumab by Caccese, Mario, Barbot, Mattia, Ceccato, Filippo, Padovan, Marta, Gardiman, Marina Paola, Fassan, Matteo, Denaro, Luca, Emanuelli, Enzo, D’Avella, Domenico, Scaroni, Carla, Zagonel, Vittorina, Lombardi, Giuseppe

“…Secreting pituitary adenomas are tumors for which few treatment options are available, including surgical treatment and management of hormonal imbalance due to…”
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RAD1901: a novel, orally bioavailable selective estrogen receptor degrader that demonstrates antitumor activity in breast cancer xenograft models by Garner, Fiona, Shomali, Maysoun, Paquin, Dotty, Lyttle, C Richard, Hattersley, Gary

“…Agents that inhibit estrogen production, such as aromatase inhibitors or those that directly block estrogen receptor (ER) activity, such as selective estrogen…”
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Cellular and clinical pharmacology of the taxanes docetaxel and paclitaxel – a review by de Weger, Vincent A, Beijnen, Jos H, Schellens, Jan H.M

“…Paclitaxel and docetaxel are active against a range of human cancers. Their antitumor activity is based on stabilization of the microtubule dynamics and…”
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Carvacrol inhibits proliferation and induces apoptosis in human colon cancer cells by Fan, Kai, Li, Xiaolei, Cao, Yonggang, Qi, Hanping, Li, Lei, Zhang, Qianhui, Sun, Hongli

“…Colon cancer is one of the most common malignancies worldwide and has a high mortality rate. Carvacrol is a major component of oregano and thyme essential oils…”
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Circular RNA circ_ASAP2 regulates drug sensitivity and functional behaviors of cisplatin-resistant gastric cancer cells by the miR-330-3p/NT5E axis by Sun, Yongjun, Ma, Jie, Lin, Junkai, Sun, Dawei, Song, Ping, Shi, Lujing, Li, Hongtao, Wang, Ruijie, Wang, Ziwen, Liu, Shijun

“…This study aims to explore the biological actions of circular RNA (circRNA) ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 (circ_ASAP2, circ_0006089)…”
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Quercetin induces apoptosis and enhances gemcitabine therapeutic efficacy against gemcitabine-resistant cancer cells by Liu, Zhi-jie, Xu, Wei, Han, Jing, Liu, Qing-yan, Gao, Li-feng, Wang, Xiao-hui, Li, Xiu-li

“…Quercetin, an abundant flavonoid found in various fruits and vegetables, displays multiple biological activities, including anticancer effects. Therefore,…”
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Emerging delivery systems to reduce doxorubicin cardiotoxicity and improve therapeutic index: focus on liposomes by Tahover, Esther, Patil, Yogita P, Gabizon, Alberto A

“…Anthracyclines are powerful anticancer agents and among the most important tools in the chemotherapy armamentarium of medical oncologists. They are approved…”
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Sonic hedgehog and Wnt/β-catenin pathways mediate curcumin inhibition of breast cancer stem cells by Li, Xiaoting, Wang, Xiaoqian, Xie, Chunfeng, Zhu, Jianyun, Meng, Yu, Chen, Yue, Li, Yuan, Jiang, Ye, Yang, Xue, Wang, Shijia, Chen, Jiaqi, Zhang, Qi, Geng, Shanshan, Wu, Jieshu, Zhong, Caiyun, Zhao, Yu

“…Cancer stem cells (CSCs) play an essential role in the progression of many tumors. Sonic hedgehog (Shh) and Wnt/β-catenin pathways are crucial in maintaining…”
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Apigenin inhibits cell proliferation, migration, and invasion by targeting Akt in the A549 human lung cancer cell line by Zhou, Zhongping, Tang, Miaomiao, Liu, Yi, Zhang, Zhuyi, Lu, Rongzhu, Lu, Jian

“…Apigenin (APG), a widely distributed flavonoid in vegetables and fruits, with low toxicity, and a nonmutagenic characteristic, has been reported to have many…”
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Sesquiterpene lactones as drugs with multiple targets in cancer treatment: focus on parthenolide by Orofino Kreuger, Maria Regina, Grootjans, Sasker, Biavatti, Maique W, Vandenabeele, Peter, D’Herde, Katharina

“…Sesquiterpene lactones (SLs) constitute a large and diverse group of biologically active plant compounds that possess anti-inflammatory and antitumor activity…”
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Cardamonin inhibits the proliferation and metastasis of non-small-cell lung cancer cells by suppressing the PI3K/Akt/mTOR pathway by Zhou, Xiaoshu, Zhou, Rui, Li, Qianwen, Jie, Xiaohua, Hong, Jiaxin, Zong, Yan, Dong, Xiaorong, Zhang, Sheng, Li, Zhenyu, Wu, Gang

“…Cardamonin, a natural chalcone compound, has been reported to exert anticancer effects in several cancers. However, the specific pharmacological actions of…”
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