Search Results - "Anthony Ratcliffe"

Mechanism of action, potency and efficacy: considerations for cell therapies by Simon, Jr, Carl G, Bozenhardt, Erich H, Celluzzi, Christina M, Dobnik, David, Grant, Melanie L, Lakshmipathy, Uma, Nebel, Thiana, Peltier, Linda, Ratcliffe, Anthony, Sherley, James L, Stacey, Glyn N, Taghizadeh, Rouzbeh R, Tan, Eddie H P, Vessillier, Sandrine

“…One of the most challenging aspects of developing advanced cell therapy products (CTPs) is defining the mechanism of action (MOA), potency and efficacy of the…”
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The translation of product concept to bone products: a partnership of therapeutic effectiveness and commercialization by Ratcliffe, Anthony

“…The fields of tissue engineering and regenerative medicine have the capacity to substantially impact clinical care through the introduction of new products…”
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A three-dimensional osteochondral composite scaffold for articular cartilage repair by Sherwood, Jill K, Riley, Susan L, Palazzolo, Robert, Brown, Scott C, Monkhouse, Donald C, Coates, Matt, Griffith, Linda G, Landeen, Lee K, Ratcliffe, Anthony

“…There is a recognized and urgent need for improved treatment of articular cartilage defects. Tissue engineering of cartilage using a cell-scaffold approach has…”
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ASTM international workshop on standards and measurements for tissue engineering scaffolds by Simon Jr, Carl G., Yaszemski, Michael J., Ratcliffe, Anthony, Tomlins, Paul, Luginbuehl, Reto, Tesk, John A.

“…The "Workshop on Standards & Measurements for Tissue Engineering Scaffolds" was held on May 21, 2013 in Indianapolis, IN, and was sponsored by the ASTM…”
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Static and dynamic compression modulate matrix metabolism in tissue engineered cartilage by Davisson, Twana, Kunig, Sabine, Chen, Albert, Sah, Robert, Ratcliffe, Anthony

“…Static and dynamic compression are known to modulate the metabolism of articular cartilage. The present study focused on determining the effects of compressive…”
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Bioreactors and Bioprocessing for Tissue Engineering by RATCLIFFE, ANTHONY, NIKLASON, LAURA E.

“…: Bioreactor design in tissue engineering is complex, and at the early stages of its development. Design of biologically effective, yet scalable, devices…”
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Report of the international conference on manufacturing and testing of pluripotent stem cells by Abbot, Stewart, Agbanyo, Francisca, Ahlfors, Jan-Eric, Baghbaderani, Behnam A., Bartido, Shirley, Bharti, Kapil, Burke, Carl, Carlsson, Bjorn, Cavagnaro, Joy, Creasey, Abla, DiGiusto, David, Francissen, Kathy, Gaffney, Andrew, Goldring, Christopher, Gorba, Thorsten, Griffiths, Elwyn, Hanatani, Tadaaki, Hayakawa, Takao, Heki, Tatsuo, Hoogendoorn, Karin, Kawamata, Shin, Kimura, Hironobu, Kirkeby, Agnete, Knezevic, Ivana, Lebkowski, Jane, Lin, Stephen, Lin-Gibson, Shen, Lubiniecki, Anthony, O'Shea, Orla, Pera, Martin, Petricciani, John, Pigeau, Gary, Ratcliffe, Anthony, Sato, Yoji, Schumann, Gerald G., Shingleton, William, Stacey (Chair), Glyn, Sullivan, Stephen, Svendsen, Clive N., Trouvin, Jean-Hugues, Vandeputte, Joris, Yuan, Bao-Zhu, Zoon, Kathryn

“…Sessions included an overview of past cell therapy (CT) conferences sponsored by the International Alliance for Biological Standardization (IABS). The sessions…”
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The Effect of Gamma Irradiation on Anterior Cruciate Ligament Allograft Biomechanical and Biochemical Properties in the Caprine Model at Time Zero and at 6 Months After Surgery by Schwartz, Herbert E., Matava, Matthew J., Proch, Frank S., Butler, Charles A., Ratcliffe, Anthony, Levy, Martin, Butler, David L.

“…Background: High levels of gamma irradiation are required to eliminate the risk of bacterial and viral transmission during implantation of musculoskeletal…”
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Chondrocyte deformation and local tissue strain in articular cartilage: a confocal microscopy study by Guilak, F, Ratcliffe, A, Mow, V C

“…It is well accepted that mechanical forces can modulate the metabolic activity of chondrocytes, although the specific mechanisms of mechanical signal…”
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Cartilage and diarthrodial joints as paradigms for hierarchical materials and structures by Mow, V C, Ratcliffe, A, Poole, A R

“…The anatomic forms of diarthrodial joints are important structural features which provide and limit the motions required for the joint. Typically, the length…”
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Fluid shear stress-induced alignment of cultured vascular smooth muscle cells by Lee, Ann A, Graham, Dionne A, Dela Cruz, Sheila, Ratcliffe, Anthony, Karlon, William J

“…The study objectives were to quantify the time- and magnitude-dependence of flow-induced alignment in vascular smooth muscle cells (SMC) and to identify…”
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Difficulties in the translation of functionalized biomaterials into regenerative medicine clinical products by Ratcliffe, Anthony

“…Abstract There are many ways to influence cell activities, and biomaterials with functional groups attached is an attractive method that clearly has the…”
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Growth factors secreted by fibroblasts: role in healing diabetic foot ulcers by Mansbridge, Jonathan N., Liu, Kang, Pinney, R. Emmett, Patch, Ruth, Ratcliffe, Anthony, Naughton, Gail K.

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Induction of apoptosis in vascular smooth muscle cells by mechanical stretch by Sotoudeh, Mohammad, Li, Yi-Shuan, Yajima, Noriyuki, Chang, Chih-Chieh, Tsou, Tsui-Chun, Wang, Yibin, Usami, Shunichi, Ratcliffe, Anthony, Chien, Shu, Shyy, John Y-J

“…We studied the response of porcine vascular smooth muscle cells (PVSMCs) to cyclic sinusoidal stretch at a frequency of 1 Hz. Cyclic stretch with an area…”
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Mechanical and biochemical changes in the superficial zone of articular cartilage in canine experimental osteoarthritis by Guilak, F, Ratcliffe, A, Lane, N, Rosenwasser, M P, Mow, V C

“…The changes in the tensile mechanical properties and biochemical composition of the superficial zone of articular cartilage were examined in a canine model of…”
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Load-Controlled Compression of Articular Cartilage Induces a Transient Stimulation of Aggrecan Gene Expression by Valhmu, Wilmot B., Stazzone, Enrico J., Bachrach, Nathaniel M., Saed-Nejad, Fatemeh, Fischer, Stuart G., Mow, Van C., Ratcliffe, Anthony

“…The effects of short- and long-term load-controlled compression on the levels of aggrecan mRNA have been determined. Results show that a compressive stress of…”
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Enthesis Repair: Challenges and Opportunities for Effective Tendon-to-Bone Healing by Derwin, Kathleen A., Galatz, Leesa M., Ratcliffe, Anthony, Thomopoulos, Stavros

“…On May 22, 2017, the National Institutes of Health (NIH)/National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) hosted a roundtable on…”
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The effects of matrix compression on proteoglycan metabolism in articular cartilage explants by Guilak, F, Meyer, B C, Ratcliffe, A, Mow, V C

“…The effects of compressive stress on the rate of proteoglycan synthesis and release were determined in bovine articular cartilage from 4-5-month-old animals…”
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The relationship between parafunctional masticatory activity and arthroscopically diagnosed temporomandibular joint pathology by Israel, H A, Diamond, B, Saed-Nejad, F, Ratcliffe, A

“…The purpose of this investigation was to assess the relationship between parafunctional masticatory activity and arthroscopically visualized changes in…”
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Tissue engineering of vascular grafts by Ratcliffe, Anthony

“…The challenge of tissue engineering blood vessels with the mechanical properties of native vessels, and with the anti-thrombotic properties required is…”
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