Search Results - "Anthony M. C. Brown"

RNAi-based chemical genetic screen identifies three small-molecule inhibitors of the Wnt/wingless signaling pathway by Gonsalves, Foster C, Klein, Keren, Carson, Brittany B, Katz, Shauna, Ekas, Laura A, Evans, Steve, Nagourney, Robert, Cardozo, Timothy, Brown, Anthony M.C, DasGupta, Ramanuj

“…Misregulated β-catenin responsive transcription (CRT) has been implicated in the genesis of various malignancies, including colorectal carcinomas, and it is a…”
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Both canonical and non-canonical Wnt signaling independently promote stem cell growth in mammospheres by Many, Alexander M, Brown, Anthony M C

“…The characterization of mammary stem cells, and signals that regulate their behavior, is of central importance in understanding developmental changes in the…”
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Wnt5a Signals through DVL1 to Repress Ribosomal DNA Transcription by RNA Polymerase I by Dass, Randall A, Sarshad, Aishe A, Carson, Brittany B, Feenstra, Jennifer M, Kaur, Amanpreet, Obrdlik, Ales, Parks, Matthew M, Prakash, Varsha, Love, Damon K, Pietras, Kristian, Serra, Rosa, Blanchard, Scott C, Percipalle, Piergiorgio, Brown, Anthony M C, Vincent, C Theresa

“…Ribosome biogenesis is essential for cell growth and proliferation and is commonly elevated in cancer. Accordingly, numerous oncogene and tumor suppressor…”
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Dysregulation of PAD4-mediated citrullination of nuclear GSK3β activates TGF-β signaling and induces epithelial-to-mesenchymal transition in breast cancer cells by Stadler, Sonja C, Vincent, C Theresa, Fedorov, Victor D, Patsialou, Antonia, Cherrington, Brian D, Wakshlag, Joseph J, Mohanan, Sunish, Zee, Barry M, Zhang, Xuesen, Garcia, Benjamin A, Condeelis, John S, Brown, Anthony M C, Coonrod, Scott A, Allis, C David

“…Peptidylarginine deiminase 4 (PAD4) is a Ca ²⁺-dependent enzyme that converts arginine and methylarginine residues to citrulline, with histone proteins being…”
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Face morphogenesis is promoted by Pbx-dependent EMT via regulation of Snail1 during frontonasal prominence fusion by Losa, Marta, Risolino, Maurizio, Li, Bingsi, Hart, James, Quintana, Laura, Grishina, Irina, Yang, Hui, Choi, Irene F, Lewicki, Patrick, Khan, Sameer, Aho, Robert, Feenstra, Jennifer, Vincent, C Theresa, Brown, Anthony M C, Ferretti, Elisabetta, Williams, Trevor, Selleri, Licia

“…Human cleft lip with or without cleft palate (CL/P) is a common craniofacial abnormality caused by impaired fusion of the facial prominences. We have…”
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Noncanonical Wnt signaling promotes osteoclast differentiation and is facilitated by the human immunodeficiency virus protease inhibitor ritonavir by Santiago, Francisco, Oguma, Junya, Brown, Anthony M.C., Laurence, Jeffrey

“…► First demonstration of direct role for noncanonical Wnt in osteoclast differentiation. ► Demonstration of Ryk as a Wnt5a/b receptor in inhibition of…”
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Wnt Proteins Induce Dishevelled Phosphorylation via an LRP5/6- Independent Mechanism, Irrespective of Their Ability To Stabilize β-Catenin by González-Sancho, José M, Brennan, Keith R, Castelo-Soccio, Leslie A, Brown, Anthony M C

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Haploinsufficiency of Flap Endonuclease (Fen1) Leads to Rapid Tumor Progression by Kucherlapati, Melanie, Yang, Kan, Kuraguchi, Mari, Zhao, Jie, Lia, Maria, Heyer, Joerg, Kane, Michael F., Fan, Kunhua, Russell, Robert, Anthony M. C. Brown, Kneitz, Burkhard, Edelmann, Winfried, Kolodner, Richard D., Lipkin, Martin, Kucherlapati, Raju

“…Flap endonuclease (Fen1) is required for DNA replication and repair, and defects in the gene encoding Fen1 cause increased accumulation of mutations and genome…”
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Wnt signalling regulates myogenic differentiation in the developing avian wing by Anakwe, Kelly, Robson, Lesley, Hadley, Julia, Buxton, Paul, Church, Vicki, Allen, Steve, Hartmann, Christine, Harfe, Brian, Nohno, Tsutomu, Brown, Anthony M C, Evans, Darrell J R, Francis-West, Philippa

“…The limb musculature arises by delamination of premyogenic cells from the lateral dermomyotome. Initially the cells express Pax3 but, upon entering the limb…”
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Truncated mutants of the putative Wnt receptor LRP6/Arrow can stabilize β-catenin independently of Frizzled proteins by BRENNAN, Keith, GONZALEZ-SANCHO, José M, CASTELO-SOCCIO, Leslie A, HOWE, Louise R, MCBROWN, Anthony

“…Secreted signaling proteins of the Wnt family are known to regulate a diverse range of developmental processes, and their signaling pathway through…”
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Mammary stem cells and cancer: roles of Wnt signaling in plain view by Many, Alexander M, Brown, Anthony M C

“…The likely roles of Wnt signaling in regulating mammary stem cell behavior have been much discussed, in part because they may underlie the oncogenic effects of…”
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Wnt signaling in liver cancer by Takigawa, Yutaka, Brown, Anthony M C

“…Hepatocellular carcinoma (HCC) is a major cause of cancer death worldwide. As in many other types of cancer, aberrant activation of the canonical…”
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Establishing estrogen-responsive mouse mammary organoids from single Lgr5 + cells by Zhang, Lixing, Adileh, Mohammad, Martin, Maria Laura, Klingler, Stefan, White, Julie, Ma, Xiaojing, Howe, Louise R, Brown, Anthony M C, Kolesnick, Richard

“…Recent evidence suggests that mammary cells expressing R-spondin receptor and Wnt pathway regulator Lgr5, regarded as a stem cell marker in multiple tissues,…”
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Microvesicle-mediated Wnt/β-Catenin Signaling Promotes Interspecies Mammary Stem/Progenitor Cell Growth by Bussche, Leen, Rauner, Gat, Antonyak, Marc, Syracuse, Bethany, McDowell, Melissa, Brown, Anthony M.C., Cerione, Richard A., Van de Walle, Gerlinde R.

“…Signaling mechanisms that regulate mammary stem/progenitor cell (MaSC) self-renewal are essential for developmental changes that occur in the mammary gland…”
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LRP6 exerts non-canonical effects on Wnt signaling during neural tube closure by Gray, Jason D, Kholmanskikh, Stanislav, Castaldo, Bozena S, Hansler, Alex, Chung, Heekyung, Klotz, Brian, Singh, Shawn, Brown, Anthony M C, Ross, M Elizabeth

“…Low-density lipoprotein receptor related protein 6 (Lrp6) mutational effects on neurulation were examined using gain (Crooked tail, Lrp6(Cd)) and loss…”
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Functional Consequences of Wnt-induced Dishevelled 2 Phosphorylation in Canonical and Noncanonical Wnt Signaling by González-Sancho, José M., Greer, Yoshimi Endo, Abrahams, Cristina L., Takigawa, Yutaka, Baljinnyam, Bolormaa, Lee, Kyung Ho, Lee, Kyung S., Rubin, Jeffrey S., Brown, Anthony M.C.

“…Dishevelled (Dvl) proteins are intracellular effectors of Wnt signaling that have essential roles in both canonical and noncanonical Wnt pathways. It has long…”
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Wnt5a signaling induces proliferation and survival of endothelial cells in vitro and expression of MMP-1 and Tie-2 by Masckauchán, T Néstor H, Agalliu, Dritan, Vorontchikhina, Marina, Ahn, Audrey, Parmalee, Nancy L, Li, Chi-Ming, Khoo, Alan, Tycko, Benjamin, Brown, Anthony M C, Kitajewski, Jan

“…Wnts are lipid-modified secreted glycoproteins that regulate diverse biological processes. We report that Wnt5a, which functions in noncanonical Wnt signaling,…”
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Wnt proteins in mammary development and cancer by Brennan, Keith R, Brown, Anthony M C

“…Secreted proteins of the Wnt family play widespread roles in the regulation of embryonic development, and aberrant activation of the canonical Wnt/beta-catenin…”
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Twist is up-regulated in response to Wnt1 and inhibits mouse mammary cell differentiation by HOWE, Louise R, WATANABE, Osamu, LEONARD, James, BROWN, Anthony M. C

“…Wnt1, initially identified as a mammary oncogene, can activate transcription via beta-catenin/TCF complexes. Twist, a transcription factor of the basic…”
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Atypical Protein Kinase Cι Is Required for Wnt3a-dependent Neurite Outgrowth and Binds to Phosphorylated Dishevelled 2 by Greer, Yoshimi Endo, Fields, Alan P., Brown, Anthony M.C., Rubin, Jeffrey S.

“…Previously we reported that Wnt3a-dependent neurite outgrowth in Ewing sarcoma family tumor cell lines was mediated by Frizzled3, Dishevelled (Dvl), and c-Jun…”
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