Search Results - "Anthony, Sarah M"
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A two-step approach to achieve secondary amide transamidation enabled by nickel catalysis
Published in Nature communications (20-05-2016)“…A long-standing challenge in synthetic chemistry is the development of the transamidation reaction. This process, which involves the conversion of one amide to…”
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Journal Article -
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Nickel-Catalyzed Esterification of Aliphatic Amides
Published in Angewandte Chemie International Edition (21-11-2016)“…Recent studies have demonstrated that amides can be used in nickel‐catalyzed reactions that lead to cleavage of the amide C−N bond, with formation of a C−C or…”
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Total Synthesis of (−)-Strictosidine and Interception of Aryne Natural Product Derivatives “Strictosidyne” and “Strictosamidyne”
Published in Journal of the American Chemical Society (19-05-2021)“…Monoterpene indole alkaloids are a large class of natural products derived from a single biosynthetic precursor, strictosidine. We describe a synthetic…”
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Arynes and Cyclic Alkynes as Synthetic Building Blocks for Stereodefined Quaternary Centers
Published in Journal of the American Chemical Society (20-06-2018)“…We report a facile method to synthesize stereodefined quaternary centers from reactions of arynes and related strained intermediates using β-ketoester-derived…”
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Leveraging Fleeting Strained Intermediates to Access Complex Scaffolds
Published in JACS Au (26-07-2021)“…Arynes, strained cyclic alkynes, and strained cyclic allenes were validated as plausible intermediates in the 1950s and 1960s. Despite initially being…”
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Catalyst-Controlled Annulations of Strained Cyclic Allenes with π‑Allylpalladium Complexes
Published in Journal of the American Chemical Society (17-05-2023)“…Strained cyclic allenes are a class of in situ-generated fleeting intermediates that, despite being discovered more than 50 years ago, has received…”
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An enzymatic Alder-ene reaction
Published in Nature (London) (01-10-2020)“…An ongoing challenge in chemical research is to design catalysts that select the outcomes of the reactions of complex molecules. Chemists rely on…”
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Journal Article -
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Nickel-Catalyzed Esterification of Aliphatic Amides
Published in Angewandte Chemie (21-11-2016)“…Recent studies have demonstrated that amides can be used in nickel‐catalyzed reactions that lead to cleavage of the amide C−N bond, with formation of a C−C or…”
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Journal Article -
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Building Complex Scaffolds Using Strained Aryne Intermediates and Chemoenzymatic Synthesis
Published 01-01-2021“…This dissertation describes research pertaining to the synthesis of natural products and reaction methodology development. The synthesis of complex molecules…”
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Dissertation -
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From heavy water to heavy aldehydes
Published in Nature catalysis (01-12-2019)“…Simple methods to incorporate deuterium into organic compounds are highly sought after as deuteration can enable mechanistic studies or improve the metabolic…”
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Journal Article